New Insights into Surgical Treatment of Hepatocellular Carcinoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 954

Special Issue Editor


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Guest Editor
1. Departement of HPB Surgery and Liver Transplantation, Beaujon Hospital, APHP, Clichy, Paris-Cité University, Paris, France
2. UMR Inserm 1275 CAP Paris-Tech, Lariboisière Hospital, Paris-Cité University, Paris, France
3. Toronto Organ Preservation Laboratory, Department of Multi Organ Transplant, University Health Network, Toronto, ON, Canada
Interests: liver cancer; pancreatic cancer; HPB surgery; liver transplantation; minimally invasive surgery; organ machine perfusion; liver regeneration; oncogenomic; regulatory T-cell therapy; biostatistical computing

Special Issue Information

Dear Colleagues,

Hepatocellular carcinoma (HCC) stands as the sixth most common cancer and the fourth most common cause of cancer-related death worldwide. Curative treatments are applicable in a minority of selected patients. HCCs most likely arise from chronic liver diseases; thus, liver transplantation theoretically offers the best chances of a cure. However, the broad use of transplantation for HCC faces various constraints, advocating for surgical resection as one of the preferred options provided there is adequate patient selection and anticipation of the postoperative risk of liver failure.

Various non-invasive tools have been promising in assessing liver functional reserve and portal pressure; they are increasingly seen as valuable for refining patients' evaluation and future liver volume optimization strategies. Furthermore, direct-acting anti-hepatitis C agents together with the growing prevalence of metabolic-associated fatty liver diseases convey new considerations. Laparoscopic and robotic approaches currently compete with ablation techniques and open procedures. Their minimally invasive nature as well as the regained attention given to perioperative immunotherapy-based protocols are new assets likely to amend both indications and results of the surgical treatment of HCC.

With this Special Issue in Cancers, we welcome original pre-clinical or clinical research articles and comprehensive or systematic reviews focusing on the surgical treatment of HCC through the spectrum of evolving tools, strategies, indications, and techniques.

Dr. Christian Hobeika
Guest Editor

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Keywords

  • hepatocellular carcinoma
  • hepatectomy
  • liver function
  • future liver volume optimization
  • liver failure
  • cirrhosis
  • MAFLD
  • portal hypertension
  • minimally invasive surgery
  • immunotherapy

Published Papers (1 paper)

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Research

15 pages, 1214 KiB  
Article
Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection
by Cristina-Paula Ursu, Andra Ciocan, Ștefan Ursu, Răzvan Alexandru Ciocan, Claudia Diana Gherman, Ariana-Anamaria Cordoș, Dan Vălean, Rodica Sorina Pop, Luminița Elena Furcea, Bogdan Procopeț, Horia Ștefănescu, Emil Ioan Moiș, Nadim Al Hajjar and Florin Graur
Cancers 2024, 16(7), 1427; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers16071427 - 07 Apr 2024
Viewed by 501
Abstract
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measurement (TE-LSM), and the association between TBS (tumor burden score), alpha-fetoprotein levels, and the Child–Pugh [...] Read more.
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measurement (TE-LSM), and the association between TBS (tumor burden score), alpha-fetoprotein levels, and the Child–Pugh classification (TAC score) can serve as valuable prognostic indicators for these patients. Therefore, the main objective of our research was to analyze the prognostic value of the HVPG, TE-LSM, TBS, and TAC scores. An observational and survival study was conducted on 144 subjects. Our findings indicated that HVPG greater than 10 mmHg, AFP surpassing 400 ng/mL, an advanced C–P class, and low TAC score are independent predictors of overall survival. During the multivariate analysis, AFP serum levels and C–P class proved statistically significant. The present study revealed significant differences in overall survival between the two groups divided upon HVPG values and settled by the cutoff of 10 mmHg (p = 0.02). Moreover, by dividing the cohort into three groups based on the TAC score (very low, low, and moderate), statistically significant differences in overall survival were observed across the groups (p = 0.004). Full article
(This article belongs to the Special Issue New Insights into Surgical Treatment of Hepatocellular Carcinoma)
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