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Cancers
Special Issues
Advances in Diagnosis, Treatment and Management of Endocrine Neoplasms
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Advances in Diagnosis, Treatment and Management of Endocrine Neoplasms

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 3648

Special Issue Editors

Prof. Dr. Pietro Giorgio Calò

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Guest Editor
Department of Surgical Sciences, University of Cagliari, 40-09124 Cagliari, Italy
Interests: thyroid; thyroidectomy; thyroid cancer; endocrine surgery; thyroid surgery; parathyroid; parathyroid surgery; parathyroidectomy; lymph node dissection; sentinel lymph node
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Salvatore Sorrenti

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Guest Editor
Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Interests: thyroid cancer; breast cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Fabio Medas

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Guest Editor
Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy
Interests: endocrine surgery; thyroid; parathyroid; mini-invasive surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endocrine neoplasm surgery has changed dramatically In the last few decades in light of the development of mini-invasive surgery, together with the principles of tailored and precision surgery and advances in the technology at our disposal (e.g., intraoperative nerve monitoring, near-infrared fluorescent imaging).

Nevertheless, many issues remain, for example, the indication and extent of surgery for thyroid carcinoma, the therapeutic options for poorly differentiated and anaplastic thyroid carcinoma, the management of patients with parathyroid carcinoma, the best surgical approach for patients with pheochromocytoma and paraganglioma, and research on novel biomarkers for neuroendocrine neoplasms.

For this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Thyroid carcinoma;
  • Parathyroid carcinoma;
  • Adrenal glands neoplasms;
  • Neuroendocrine neoplasms.

We look forward to receiving your contributions.

Prof. Dr. Pietro Giorgio Calò
Prof. Dr. Salvatore Sorrenti
Prof. Dr. Fabio Medas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • thyroid carcinoma
  • thyroidectomy
  • parathyroid carcinoma
  • parathyroidectomy
  • adrenal gland neoplasms
  • adrenalectomy
  • neuroendocrine neoplasms

Published Papers (2 papers)

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Research

9 pages, 417 KiB  
Article
Surgical Management of Indeterminate Thyroid Nodules across Different World Regions: Results from a Retrospective Multicentric (the MAIN-NODE) Study
by Gian Luigi Canu, Federico Cappellacci, Ahmed Abdallah, Islam Elzahaby, David Figueroa-Bohorquez, Eleonora Lori, Julie A. Miller, Sergio Zúñiga Pavia, Pilar Pinillos, Atcharaporn Pongtippan, Saleh Saleh Saleh, Salvatore Sorrenti, Chutintorn Sriphrapradang, Pietro Giorgio Calò and Fabio Medas
Cancers 2023, 15(15), 3996; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers15153996 - 07 Aug 2023
Viewed by 1425
Abstract
Indeterminate thyroid nodules (ITNs) are characterized by an expected malignancy ranging from 5% to 30%, with most patients undergoing a diagnostic, rather than therapeutic, operation. The aim of our study was to compare the approach to ITNs across different regions of the world. [...] Read more.
Indeterminate thyroid nodules (ITNs) are characterized by an expected malignancy ranging from 5% to 30%, with most patients undergoing a diagnostic, rather than therapeutic, operation. The aim of our study was to compare the approach to ITNs across different regions of the world. In this retrospective, multicentric, international study, according to the WHO classification, we identified the South East Asian Region (SEAR), the Americas Region (AMR), the Eastern Mediterranean Region (EMR), the Europe Region (EUR), and the Western Pacific Region (WPR). One high-volume thyroid centre was included for each region. Demographic, preoperative, and pathologic data were compared among the different regions. Overall, 5737 patients from five high-volume thyroid centres were included in this study. We found that the proportion of ITNs over the global activity for thyroid disease was higher in the EUR (37.6%) than in the other regions (21.1–23.6%). In the EMR, the patients were significantly younger (with a mean of 43.1 years) than in the other regions (range, 48.8–57.4 years). The proportion of lobectomy was significantly higher in the WPR, where 83.2% (114/137) of patients received this treatment, than in the other regions, where lobectomies were performed in 44.1–58.1% of patients. The pathological diagnosis of malignancy was significantly higher in the SEAR centre, being over 60%, than in centres of the other regions, where it ranged from 26.3% to 41.3%. The occurrence of lymph node metastases was higher in the WPR (27.8%), AMR (26.9%), and EMR (20%) centres than in the EUR and SEAR centres, where it was lower than 10%. In summary, we found in our study different approaches and outcomes in the diagnosis and treatment of ITNs among countries. Overall, almost 60% of patients with ITNs who underwent surgery actually presented a benign disease, potentially undergoing an unnecessary operation. Full article
(This article belongs to the Special Issue Advances in Diagnosis, Treatment and Management of Endocrine Neoplasms)
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12 pages, 4740 KiB  
Article
US Evaluation of Topical Hemostatic Agents in Post-Thyroidectomy
by Vincenzo Dolcetti, Eleonora Lori, Daniele Fresilli, Giovanni Del Gaudio, Chiara Di Bella, Patrizia Pacini, Vito D’Andrea, Fabrizio Maria Frattaroli, Giulia Giordana Vallone, Piero Liberatore, Daniele Pironi, Gian Luigi Canu, Pietro Giorgio Calò, Vito Cantisani and Salvatore Sorrenti
Cancers 2023, 15(9), 2644; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers15092644 - 07 May 2023
Cited by 2 | Viewed by 1666
Abstract
Background: the aim of this study was to describe the ultrasound appearance of topical hemostatics after thyroidectomy. Methods: we enrolled 84 patients who were undergoing thyroid surgery and were treated with two types of topical hemostats, 49 with an absorbable hemostat of oxidized [...] Read more.
Background: the aim of this study was to describe the ultrasound appearance of topical hemostatics after thyroidectomy. Methods: we enrolled 84 patients who were undergoing thyroid surgery and were treated with two types of topical hemostats, 49 with an absorbable hemostat of oxidized regenerated cellulose (Oxitamp®) and 35 with a fibrin glue-based hemostat (Tisseel®). All patients were examined using B-mode ultrasound. Results: In 39 patients of the first group (approximately 80%), a hemostatic residue was detected and in some cases confused with a native gland residue, or with cancer recurrence in oncological patients. No residue was detected in patients in the second group. The main ultrasound characteristics of the tampon were analyzed and arranged according to predefined patterns, and suggestions to recognize it and avoid wrong diagnoses were provided. A part of the group of patients with tampon residue was re-evaluated after 6–12 months, ensuring that the swab remained for months after the maximum resorption time declared by the manufacturer. Conclusions: with equal hemostatic effectiveness, the fibrin glue pad is more favorable in the ultrasound follow-up because it creates reduced surgical outcomes. It is also important to know and recognize the ultrasound characteristics of oxidized cellulose-based hemostats in order to reduce the number of diagnostic errors and inappropriate diagnostic investigations. Full article
(This article belongs to the Special Issue Advances in Diagnosis, Treatment and Management of Endocrine Neoplasms)
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