Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
5.2
Journals
Cancers
Special Issues
Partial Breast Radiotherapy: Evidence and Challenges
share announcement

Partial Breast Radiotherapy: Evidence and Challenges

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1357

Special Issue Editor

Dr. Pedro Carlos Lara

E-Mail Website
Guest Editor
Comprehensive Cancer Center, San Roque University Hospital, Fernando Pessoa Canarias University, Las Palmas de Gran Canaria, Spain
Interests: breast; radiation; brachytherapy; IORT

Special Issue Information

Dear Colleagues,

Guidelines from GEC-ESTRO, ASTRO and ABS defined patients to whom the following could be safely reduced: (a) the breast volume irradiated, (b) the treatment time, and (c) unnecessary radiation exposure to healthy tissues. For these reasons, the concept of accelerated partial breast irradiation (APBI) in early breast cancer after BCS has gained acceptance.

There are several radiation techniques for APBI. Brachytherapy, external beam radiotherapy, and IORT are accepted APBI techniques following data provided by phase III trials. Non-inferior results in terms of local control and suggested improved toxicity encourage APBI treatment worldwide.

The aim of the present Special Issue is to shed light on the challenges in APBI treatment, including non-cancer death rates, biological and immunological effects of tumor bed irradiation, and combination with other cancer treatments.

Dr. Pedro Carlos Lara
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • APBI
  • breast
  • radiotherapy
  • boost
  • brachytherapy
  • IORT

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

10 pages, 801 KiB  
Article
Ten-Year Results of Accelerated Partial-Breast Irradiation with Interstitial Multicatheter Brachytherapy after Breast-Conserving Surgery for Low-Risk Early Breast Cancer
by Nieves G. Rodríguez-Ibarria, Beatriz Pinar, Laura García, Auxiliadora Cabezón, Dolores Rey-Baltar, Juan Ignacio Rodríguez-Melcón, Marta Lloret and Pedro C. Lara
Cancers 2024, 16(6), 1138; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers16061138 - 13 Mar 2024
Viewed by 500
Abstract
Patients with an early carcinoma of the breast are commonly treated by breast-conserving surgery (BCS) and postoperative radiotherapy. Partial-breast irradiation has gained acceptance in the last few years. Between December 2008 and December 2017, 182 low-risk breast cancer patients treated by BCS in [...] Read more.
Patients with an early carcinoma of the breast are commonly treated by breast-conserving surgery (BCS) and postoperative radiotherapy. Partial-breast irradiation has gained acceptance in the last few years. Between December 2008 and December 2017, 182 low-risk breast cancer patients treated by BCS in the four university hospitals of the province of Las Palmas and treated with APBI using interstitial multicatheter brachytherapy were included in this study. After a mean follow-up for survivors of 10 years, the treatment was shown to be safe, as no severe acute/late toxicity (grade ≥ 3) was observed. The 10-year IBTR was 1.7% (95%CI: 0.7–2.7%), and the cause-specific survival was 94.9% (95%CI: 93.2–96.6%). We suggest that multicatheter brachytherapy after BCS is safe and effective in early breast cancer patients. Full article
(This article belongs to the Special Issue Partial Breast Radiotherapy: Evidence and Challenges)
►▼ Show Figures

Figure 1

10 pages, 258 KiB  
Article
Combined Ultrahypofractionated Whole-Breast Irradiation and IORT-Boost: A Safety and Feasibility Analysis
by Javier Burgos-Burgos, Víctor Vega, David Macias-Verde, Virginia Gómez, Elena Vicente, Carmen Murias, Carlos Santana and Pedro C. Lara
Cancers 2024, 16(6), 1105; https://0-doi-org.brum.beds.ac.uk/10.3390/cancers16061105 - 09 Mar 2024
Viewed by 660
Abstract
Background: The current standard of local treatment for patients with localized breast cancer (BC) includes whole breast irradiation (WBI) after breast-conserving surgery (BCS). Ultrahypofractionated WBI schemes (1-week treatment) were shown not to be inferior to the standard WBI. Tumor bed boost using photon [...] Read more.
Background: The current standard of local treatment for patients with localized breast cancer (BC) includes whole breast irradiation (WBI) after breast-conserving surgery (BCS). Ultrahypofractionated WBI schemes (1-week treatment) were shown not to be inferior to the standard WBI. Tumor bed boost using photon intraoperative radiotherapy (IORT) is safe and feasible in combination with standard WBI. The aim of the present study is to assess, for the first time, the feasibility and safety of combining photon IORT with ultrahypofractionated WBI. Methods: Patients diagnosed with low-risk early BC candidates for BCS were included in this prospective study. IORT was administered at a dose of 20 Gy to the surface’s applicator, and WBI was administered 3–5 weeks after surgery at a total dose of 26 Gy in five consecutive days. Results: From July 2020 to December 2022, seventy-two patients diagnosed with low-risk early BC and treated in our institution were included in this prospective study. All patients completed the proposed treatment, and no severe acute or late grade 3 toxicity was observed 3 and 12 months after WBI, respectively. Conclusions: Our results confirm for the first time that the combination of ultrafractionation WBI and photon-IORT after BCS is a feasible and safe option in patients with early BC. Full article
(This article belongs to the Special Issue Partial Breast Radiotherapy: Evidence and Challenges)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop