Unraveling the Hidden Impacts of Alcohol on Neurological and Cardiovascular Health

Dear Colleagues,

This Special Issue probes into the veiled consequences of alcohol on health, arising from singular exposure, long-term consumption, or instances of excessive drinking. It particularly delves into the metabolic processes, the formation of adducts, non-enzymatic metabolism, and a range of substrates possibly impacted by alcohol or its metabolites. It also uncovers molecular pathways linking alcohol to organ and tissue damage, develops biomarkers to track and measure alcohol-induced pathologies, and traces the origins and progression of health disorders instigated by alcohol consumption. Utilizing systems biology, bioinformatics, and real-time imaging techniques, we aim to decipher biological networks and pathways implicated in alcohol metabolism and related damage across different stages of life. Alcohol can disrupt the brain's intricate communication systems, altering its structure and functionality. These interferences can lead to changes in mood and behavior, impair cognitive clarity, and affect coordination. Persistent or excessive drinking can adversely impact the heart, potentially leading to conditions such as cardiomyopathy, characterized by the enlargement and sagging of heart muscle; arrhythmias, resulting in an irregular heartbeat; strokes; and hypertension.

Dr. Manikandan Panchatcharam
Dr. Sumitra Miriyala
Guest Editors

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• alcohol
• brain
• neurogenesis
• apoptosis
• ischemic stroke, blood–brain barrier
• ischemic-reperfusion
• lysolipids
• permeability
• microglia
• sex differences
• neurodegeneration
• calcium
• oxidative stress
• cAMP
• mitochondria
• proteostasis
• autophagy
• inflammation
• ER stress
• metabolism