Role of Inflammasomes in Energy Metabolism and Glucose Homeostasis

Dear Colleagues,

Metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), cardiovascular diseases, and fatty liver disease, are leading causes for preventable death in the U.S. and worldwide, and are a huge healthcare burden in terms of economics, quality of life, and morbidity/mortality. Inflammation has become one of the hottest research areas in the field of metabolic disorders in recent years.  Inflammasomes are part of the innate immune system. They are intracellular oligomers that act as receptors and sensors that regulate the production of interleukin (IL)-1β and IL-18 in response to infectious microbes or molecules.

Recent research has demonstrated that inflammasomes are also involved in the regulation of energy metabolism and whole-body glucose homeostasis, indicating that inflammasomal proteins could be novel targets for treating metabolic disorders. Thus, this Special Issue aims to highlight recent advances in our understanding of the role of inflammasomes in energy metabolism, glucose homeostasis, and underlying molecular mechanisms. We invite you to submit your original research articles as well as review articles to facilitate the understanding of this newer field.

Dr. Zhenwei Gong
Guest Editor

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• inflammasomes
• energy metaboism
• metabolic syndrome
• chronic inflammation
• cytokine production