Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.9
4.2
Journals
Chemosensors
Special Issues
Applications of Probe Sensing in Medicine
share announcement

Applications of Probe Sensing in Medicine

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "(Bio)chemical Sensing".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 12687

Special Issue Editors

Prof. Dr. Huan-Tsung Chang

E-Mail Website
Guest Editor
Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan
Interests: nanoscience; green chemistry; fluorescence; sensors; surface enhanced Raman spectroscopy; mass spectrometry; separation sciences; fuel cells
Special Issues, Collections and Topics in MDPI journals
Dr. Yen-Ling Chen

E-Mail Website
Guest Editor
Department of Chemistry and Biochemsitry, National Chung Cheng University, Chiayi 621, Taiwan
Interests: separation science; biosensors; bioanalysis
Dr. Yi-Hui Lin

E-Mail Website
Guest Editor
School of Pharmacy, China Medical University, Taichung 404, Taiwan
Interests: separation science; pharmaceutical analysis

Special Issue Information

Dear Colleagues,

The early diagnosis and treatment of disease have a significant impact on the prognosis of patients. However, inter-individual differences and the complexity of the microenvironment of living organisms bring create challenges for monitoring the target of significance. Sensing probes have been widely used in medical-related testing. In addition to helping us understand the pathological processes, they also play a key role in drug monitoring and disease prevention.

Because of the rapid development in the area of chemical sensors in recent years, Chemosensors along with guest editors Prof. Huan-Tsung Chang (National Taiwan University), Dr. Yen-Ling Chen (National Chung Cheng University), and Dr.  Yi-Hui Lin (China Medical University) are planning to produce a Special Issue on the topic of Applications of Probe Sensing in Medicine.

The Special Issue will provide a platform for the latest research topics to be discussed, including (but not limited to) probe sensing in therapeutic drug monitoring in body fluids, drug-abuse detection, pathogenic microbe detection, biomarker detection, and genetic testing and diagnosis. We would be pleased if you would accept our invitation to submit a manuscript on the related topics.

All manuscripts will be handled by the Chemsensors Editorial Office, and will be refereed in accordance to the standard procedures of the journal. Both original articles and review articles are welcomed.

Prof. Dr. Huan-Tsung Chang
Dr. Yen-Ling Chen
Dr. Yi-Hui Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Therapeutic drug monitoring
  • Abuse drug detection
  • Pathogenic microbe detection
  • Biomarker detection
  • Genetic test
  • Diagnosis
  • Sensor

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 3127 KiB  
Article
Experimental-Theoretical Approach for the Chemical Detection of Glyphosate and Its Potential Interferents Using a Copper Complex Fluorescent Probe
by Guilherme Martins, Karolyne V. Oliveira, Saddam Weheabby, Ammar Al-Hamry, Olfa Kanoun, Tobias Rüffer, Benedito J. C. Cabral and Leonardo G. Paterno
Chemosensors 2023, 11(3), 194; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors11030194 - 16 Mar 2023
Cited by 1 | Viewed by 1387
Abstract
The present contribution proposes an optical method for the detection of glyphosate (GLY) using a Cu(II) bis-(oxamate) complex ([Cu(opba)]2−) as the fluorescent probe. It wa found that in acetonitrile solution, its fluorescence increases in the presence of GLY and scales linearly [...] Read more.
The present contribution proposes an optical method for the detection of glyphosate (GLY) using a Cu(II) bis-(oxamate) complex ([Cu(opba)]2−) as the fluorescent probe. It wa found that in acetonitrile solution, its fluorescence increases in the presence of GLY and scales linearly (R2 = 0.99) with GLY concentration in the range of 0.7 to 5.5 µM, which is far below that established by different international regulations. The probe is also selective to GLY in the presence of potential interferents, namely aminomethyl phosphonic acid and N-nitrosoglyphosate. Theoretical results obtained by time-dependent density functional theory coupled to a simplified treatment of the liquid environment by using a self-consistent reaction-field revealed that GLY molecules do not coordinate with the central Cu2+ ion of [Cu(opba)]2−; instead, they interact with its peripheral ligand through hydrogen bond formation. Thereby, GLY plays mainly the role of the proton donor. The results also suggest that GLY increases the dielectric constant of the medium when it contributes to the stabilization of the excited state of the [Cu(opba)]2− and enhancement of its fluorescence. Full article
(This article belongs to the Special Issue Applications of Probe Sensing in Medicine)
►▼ Show Figures

Figure 1

13 pages, 3127 KiB  
Article
Sensing Alzheimer’s Disease Utilizing Au Electrode by Controlling Nanorestructuring
by Chih-Hsien Hsu, Akhilesh Kumar Gupta, Agnes Purwidyantri, Briliant Adhi Prabowo, Ching-Hsiang Chen, Chi-Cheng Chuang, Ya-Chung Tian, Yu-Jen Lu and Chao-Sung Lai
Chemosensors 2022, 10(3), 94; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors10030094 - 27 Feb 2022
Cited by 10 | Viewed by 3629
Abstract
This paper reports the development of Alzheimer’s disease (AD) sensor through early detection of amyloid-beta (Aβ) (1–42) using simple nanorestructuring of Au sheet plate by oxidation-reduction cycle (ORC) via the electrochemical system. The topology of Au substrates was enhanced through the roughening and [...] Read more.
This paper reports the development of Alzheimer’s disease (AD) sensor through early detection of amyloid-beta (Aβ) (1–42) using simple nanorestructuring of Au sheet plate by oxidation-reduction cycle (ORC) via the electrochemical system. The topology of Au substrates was enhanced through the roughening and Au grains grown by a simple ORC technique in aqueous solutions containing 0.1 mol/L KCl electrolytes. The roughened substrate was then functionalized with the highly specific antibody β-amyloid Aβ (1–28) through HS-PEG-NHS modification, which enabled effective and direct detection of Aβ (1–42) peptide. The efficacy of the ORC method had been exhibited in the polished Au surface by approximately 15% larger electro-active sites compared to the polished Au without ORC. The ORC polished structure demonstrated a rapid, accurate, precise, reproducible, and highly sensitive detection of Aβ (1–42) peptide with a low detection limit of 10.4 fg/mL and a wide linear range of 10−2 to 106 pg/mL. The proposed structure had been proven to have potential as an early-stage Alzheimer’s disease (AD) detection platform with low-cost fabrication and ease of operation. Full article
(This article belongs to the Special Issue Applications of Probe Sensing in Medicine)
►▼ Show Figures

Figure 1

10 pages, 2254 KiB  
Communication
Application of Peroxidase-Mimic Mn2BPMP Boosted by ADP to Enzyme Cascade Assay for Glucose and Cholesterol
by Namgeol Lee, Soyeon Yoo, Youngkeun Lee and Min Su Han
Chemosensors 2022, 10(2), 89; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors10020089 - 21 Feb 2022
Viewed by 2148
Abstract
The Mn2BPMP complex has an intrinsic peroxidase-like activity in the pH range of 5 to 8, especially a maximum activity at pH 7, while most peroxidase mimics operate at an acidic pH (mainly pH 4). Its peroxidase-like activity is high among [...] Read more.
The Mn2BPMP complex has an intrinsic peroxidase-like activity in the pH range of 5 to 8, especially a maximum activity at pH 7, while most peroxidase mimics operate at an acidic pH (mainly pH 4). Its peroxidase-like activity is high among small-molecule-based peroxidase mimics with a high reproducibility. In addition, we recently revealed that adenosine mono/diphosphate (AMP and ADP) significantly boosted the peroxidase-like activity of Mn2BPMP. These advantages imply that Mn2BPMP is suitable for biosensing as a substitute for horseradish peroxidase (HRP). Herein, we established a colorimetric one-pot assay system using the enzyme cascade reaction between analyte oxidase and ADP-boosted Mn2BPMP. The simple addition of ADP to the Mn2BPMP-based assay system caused a greater increase in absorbance for the same concentration of H2O2, which resulted in a higher sensitivity. It was applied to one-pot detection of glucose and cholesterol at 25 °C and pH 7.0 for a few minutes. Full article
(This article belongs to the Special Issue Applications of Probe Sensing in Medicine)
►▼ Show Figures

Graphical abstract

14 pages, 2089 KiB  
Article
Development of Fluorescent Carbon Nanoparticle-Based Probes for Intracellular pH and Hypochlorite Sensing
by Yu-Syuan Lin, Li-Wei Chuang, Yu-Feng Lin, Shun-Ruei Hu, Chih-Ching Huang, Yu-Fen Huang and Huan-Tsung Chang
Chemosensors 2022, 10(2), 64; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors10020064 - 05 Feb 2022
Cited by 4 | Viewed by 2106
Abstract
Acid-base and redox reactions are important mechanisms that affect the optical properties of fluorescent probes. Fluorescent carbon nanoparticles (CNPs) that possess tailored surface functionality enable a prompt response to regional stimuli, offering a useful platform for detection, sensing, and imaging. In this study, [...] Read more.
Acid-base and redox reactions are important mechanisms that affect the optical properties of fluorescent probes. Fluorescent carbon nanoparticles (CNPs) that possess tailored surface functionality enable a prompt response to regional stimuli, offering a useful platform for detection, sensing, and imaging. In this study, mPA CNPs were developed through one-pot hydrothermal reaction as a novel fluorescent probe (quantum yield = 10%) for pH and hypochlorite sensing. m-Phenylenediamine was chosen as the major component of CNPs for pH and hypochlorite responsiveness. Meanwhile, ascorbic acid with many oxygen-containing groups was introduced to generate favorable functionalities for improved water solubility and enhanced sensing response. Thus, the mPA CNPs could serve as a pH probe and a turn-off sensor toward hypochlorite at neutral pH through fluorescence change. The as-prepared mPA CNPs exhibited a linear fluorescence response over the pH ranges from pH 5.5 to 8.5 (R2 = 0.989), and over the concentration range of 0.125–1.25 μM for hypochlorite (R2 = 0.985). The detection limit (LOD) of hypochlorite was calculated to be 0.029 μM at neutral pH. The mPA CNPs were further applied to the cell imaging. The positively charged surface and nanoscale dimension of the mPA CNPs lead to their efficient intracellular delivery. The mPA CNPs were also successfully used for cell imaging and sensitive detection of hypochlorite as well as pH changes in biological systems. Given these desirable performances, the as-synthesized fluorescent mPA CNPs shows great potential as an optical probe for real-time pH and hypochlorite monitoring in living cells. Full article
(This article belongs to the Special Issue Applications of Probe Sensing in Medicine)
►▼ Show Figures

Figure 1

20 pages, 4051 KiB  
Article
Gold Nanoparticles/Carbon Nanotubes and Gold Nanoporous as Novel Electrochemical Platforms for L-Ascorbic Acid Detection: Comparative Performance and Application
by Cristina Tortolini, Federico Tasca, Mary Anna Venneri, Cinzia Marchese and Riccarda Antiochia
Chemosensors 2021, 9(8), 229; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors9080229 - 16 Aug 2021
Cited by 9 | Viewed by 2638
Abstract
Herein, the effects of nanostructured modifications of a gold electrode surface in the development of electrochemical sensors for L-ascorbic acid detection have been investigated. In particular, a bare gold electrode has been modified by electrodeposition of gold single-walled carbon nanotubes (Au/SWCNTs) and by [...] Read more.
Herein, the effects of nanostructured modifications of a gold electrode surface in the development of electrochemical sensors for L-ascorbic acid detection have been investigated. In particular, a bare gold electrode has been modified by electrodeposition of gold single-walled carbon nanotubes (Au/SWCNTs) and by the formation of a highly nanoporous gold (h-nPG) film. The procedure has been realized by sweeping the potential between +0.8 V and 0 V vs. Ag/AgCl for 25 scans in a suspension containing 5 mg/mL of SWCNTs in 10 mM HAuCl4 and 2.5 M NH4Cl solution for Au/SWCNTs modified gold electrode. A similar procedure was applied for a h-nPG electrode in a 10 mM HAuCl4 solution containing 2.5 M NH4Cl, followed by applying a fixed potential of −4 V vs. Ag/AgCl for 60 s. Cyclic voltammetry and electrochemical impedance spectroscopy were used to characterize the properties of the modified electrodes. The developed sensors showed strong electrocatalytic activity towards ascorbic acid oxidation with enhanced sensitivities of 1.7 × 10−2 μA μM−1cm−2 and 2.5 × 10−2 μA μM−1cm−2 for Au/SWCNTs and h-nPG modified electrode, respectively, compared to bare gold electrode (1.0 × 10−2 μA μM−1cm−2). The detection limits were estimated to be 3.1 and 1.8 μM, respectively. The h-nPG electrode was successfully used to determine ascorbic acid in human urine with no significant interference and with satisfactory recovery levels. Full article
(This article belongs to the Special Issue Applications of Probe Sensing in Medicine)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop