Adolescent Weight Management: Advances and Future Challenges

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Global and Public Health".

Deadline for manuscript submissions: 10 December 2024 | Viewed by 2919

Special Issue Editor


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Guest Editor
2nd Department of Paediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA University General Hospital, Thessaloniki, Greece
Interests: adolescents; glucose metabolism; obesity; prediabetes; impaired glucose tolerance; type 2 diabetes mellitus; hyperinsulinaemia; insulin resistance; endocrine late effects in childhood cancer survivors; type 1 diabetes mellitus; hyperglycaemia; diabetic complications; growth; short stature

Special Issue Information

Dear Colleagues,

Adolescent weight management constitutes an important challenge in the clinical practice of health care providers. Since the rates of excess in body weight among adolescents have risen dramatically in multinational epidemiological data, the effective support of an adolescent diagnosed with obesity is an increasingly frequent requirement. This increase in adolescent overweight and obesity has been linked to a variety of non-communicable diseases, including type 2 diabetes, cardiovascular disease, and mental health issues, all of them correlated to augmented morbidity during early adult life.

Current advances in adolescent weight management have focused on comprehensive, multi-component interventions that address nutrition, activity, and mental health. These interventions often include a combination of behavioural modification, nutritional education, physical activity promotion, and family involvement. Several studies have shown that these comprehensive interventions can offer a reduction in BMI and improvement in health outcomes among overweight and obese adolescents. Novel pharmaceutical agents released in recent years to treat adolescents with obesity have also enhanced the therapeutic options of health care providers. Recent advances in our knowledge of underlying genetic causes of obesity have also offered a novel perspective of therapeutic management, in a relatively small but extremely difficult to handle group of adolescents with severe genetic forms of obesity.  

Another major advance in adolescent weight management is the use of technology-based interventions, utilizing software applications, websites, and other digital tools which have been designed to provide adolescents with continuous motivation for an engagement to a healthy lifestyle. These technology-based interventions can be particularly effective for supporting and motivating adolescents, who are often highly familiar with digital tools.

Despite all these advances, there is a wide range of unmet needs and several challenges to be addressed by the health care professionals dealing with adolescent weight management. The sustainability of weight management interventions over the long term constitutes the most prominent issue. Struggling to maintain the newly introduced healthy behaviours after the end of an intervention is a common issue that sometimes leads to weight regain. Future interventions need to focus on providing ongoing support and reinforcement to maintain the initially prominent healthy results.

Another challenge focuses on efficiently addressing the underlying social and environmental factors that contribute to adolescent overweight and obesity. Food marketing, the availability of unhealthy food, and a lack of safe places for physical activity burdens adolescents from engaging in a healthy lifestyle. Future interventions need to incorporate strategies that target these social factors and promote the creation of an environment supporting healthy eating and physical activity.

In conclusion, current advances in adolescent weight management provide promise in reducing overweight and obesity rates among adolescents. However, there are still challenges that need to be addressed to ensure the long-term success of these interventions. Future research should focus on sustainability, technology-based interventions, and addressing social and environmental factors to create lasting change in adolescent weight management.

Dr. Eleni P Kotanidou
Guest Editor

Manuscript Submission Information

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Keywords

  • adolescent
  • teen
  • obesity
  • overweight
  • management
  • pharmacotherapy

Published Papers (2 papers)

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Research

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9 pages, 895 KiB  
Article
New Clinical Markers of Oxidized Lipid-Associated Protein Damage in Children and Adolescents with Obesity
by Eirini Kostopoulou, Athina Varemmenou, Electra Kalaitzopoulou, Polyxeni Papadea, Marianna Skipitari, Andrea Paola Rojas Gil, Bessie E. Spiliotis, Sotirios Fouzas and Christos D. Georgiou
Children 2024, 11(3), 314; https://0-doi-org.brum.beds.ac.uk/10.3390/children11030314 - 06 Mar 2024
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Abstract
Obesity in children and adolescents has been associated with oxidative stress (OS). The lipid hydroperoxides (LOOH) and the malondialdehyde (MDA) and thiobarbituric reactive substances (TBARS) that oxidatively modify proteins (Pr) (i.e., PrMDA and PrTBARS, respectively) represent markers of OS-associated lipid peroxidation. We aimed [...] Read more.
Obesity in children and adolescents has been associated with oxidative stress (OS). The lipid hydroperoxides (LOOH) and the malondialdehyde (MDA) and thiobarbituric reactive substances (TBARS) that oxidatively modify proteins (Pr) (i.e., PrMDA and PrTBARS, respectively) represent markers of OS-associated lipid peroxidation. We aimed to assess OS in children and adolescents with obesity using—for the first time—markers involved in the early and late lipid oxidation process. LOOH, PrMDA, and PrTBARS were investigated in 41 children and adolescents with obesity and 31 controls. Obesity was defined as BMI > 95% for age and sex. The PrMDA/PrTBARS pair, which reflects a late peroxidation stage, was found to be significantly high (39%/180%) in children and adolescents with obesity compared to controls (p < 0.001). Similarly, the early LOOH peroxidation stage marker was increased by 30%. The studied OS parameters were not influenced by sex or age. Our study introduces LOOH, PrTBARS, and PrMDA as markers for evaluating OS in children and adolescents with obesity. LOOH, PrTBARS, and PrMDA may also hold promise as prognostic markers for potential obesity-associated long-term complications. Full article
(This article belongs to the Special Issue Adolescent Weight Management: Advances and Future Challenges)
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Review

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14 pages, 506 KiB  
Review
Syndromic and Monogenic Obesity: New Opportunities Due to Genetic-Based Pharmacological Treatment
by Kallirhoe Kalinderi, Vasiliki Goula, Evdoxia Sapountzi, Vasiliki Rengina Tsinopoulou and Liana Fidani
Children 2024, 11(2), 153; https://0-doi-org.brum.beds.ac.uk/10.3390/children11020153 - 25 Jan 2024
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Abstract
Obesity is a significant health problem with a continuously increasing prevalence among children and adolescents that has become a modern pandemic during the last decades. Nowadays, the genetic contribution to obesity is well-established. For this narrative review article, we searched PubMed and Scopus [...] Read more.
Obesity is a significant health problem with a continuously increasing prevalence among children and adolescents that has become a modern pandemic during the last decades. Nowadays, the genetic contribution to obesity is well-established. For this narrative review article, we searched PubMed and Scopus databases for peer-reviewed research, review articles, and meta-analyses regarding the genetics of obesity and current pharmacological treatment, published in the English language with no time restrictions. We also screened the references of the selected articles for possible additional articles in order to include most of the key recent evidence. Our research was conducted between December 2022 and December 2023. We used the terms “obesity”, “genetics”, “monogenic”, “syndromic”, “drugs”, “autosomal dominant”, “autosomal recessive”, “leptin-melanocortin pathway”, and “children” in different combinations. Recognizing the genetic background in obesity can enhance the effectiveness of treatment. During the last years, intense research in the field of obesity treatment has increased the number of available drugs. This review analyzes the main categories of syndromic and monogenic obesity discussing current data on genetic-based pharmacological treatment of genetic obesity and highlighting the necessity that cases of genetic obesity should follow specific, pharmacological treatment based on their genetic background. Full article
(This article belongs to the Special Issue Adolescent Weight Management: Advances and Future Challenges)
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