Special Issue "Clinic Research on Kawasaki Disease in Children"

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Global and Public Health".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Mamoru Ayusawa
E-Mail Website
Guest Editor
Department of Pediatrics and Child Health, Nihon University School of Medicine & Itabashi Hospital, Tokyo, Japan
Interests: Kawasaki disease; pediatrics; pediatric cardiology; ventricular arrhythmias; sudden cardiac death (SCD)

Special Issue Information

Dear Colleagues,

In 1961, Dr. Tomisaku Kawasaki noticed a strange combination of characteristic manifestations in young children. He collected 50 similar cases into his ‘God Only Knows’ file. This file demonstrated a historical case series of a unique and complicated disease, which was later bore his name. After more than 60 years since the first case, we have obtained extensive knowledge about Kawasaki disease (KD). The countries where KD is diagnosed and treated are gradually increasing, particularly in Asia and Latin America, in addition to Japan, Korea, Taiwan, Australia, and the United States. Many researchers are competing to discover the distinct cause of this unique phenomenon.

However, its etiology has not been clearly elucidated. Particularly, discussions concerning its relationship with multisystem inflammatory syndrome induced by SARS-CoV2 was raised suddenly in 2020–2021. Its resemblance to KD is a hot topic and a significant key to the disclosure of the pathophysiology of KD.

We would like to collect novel discussions from all clinicians and researchers who are interested in this unique disease.

Prof. Dr. Mamoru Ayusawa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Kawasaki disease (KD)
  • Coronary artery aneurysm
  • Immunoglobulin
  • Vasculitis
  • Multisystem inflammatory syndrome in children (MIS-C)
  • Children or child

Published Papers (1 paper)

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Research

Article
Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in Japan: A Single-Center, Observational Study
Children 2021, 8(10), 913; https://0-doi-org.brum.beds.ac.uk/10.3390/children8100913 - 13 Oct 2021
Viewed by 206
Abstract
Background: Under the Coronavirus disease 2019 (COVID-19) pandemic, manifestations in children with Kawasaki disease (KD) are different between the Western and the Eastern countries. Particularly, there has not been a report comparing a series of KD in Japan, where KD was originally discovered [...] Read more.
Background: Under the Coronavirus disease 2019 (COVID-19) pandemic, manifestations in children with Kawasaki disease (KD) are different between the Western and the Eastern countries. Particularly, there has not been a report comparing a series of KD in Japan, where KD was originally discovered and has a large number of registered cases. Methods: We compared patients with KD under the period of the COVID-19 pandemic in Japan with the report from Italy during its reported period by a retrospective, cohort, observational study in a Japanese single center. Results: Thirty-two patients with typical KD were treated during the study period, while the Italian study reported 10 patients with the signs of KD. Concerning the proof of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, none (0%) of our KD cases showed a positive result and one and no patients developed the macrophage activation syndrome (MAS) and Kawasaki disease shock syndrome (KDSS), respectively; however, eight (80%) patients in the Italian series were confirmed with SARS-CoV-2 infection. MAS and KDSS developed in six and five patients, respectively. Conclusions: Cases reported as COVID-19 pandemic-related KD in Italy showed significantly different clinical characteristics from the typical KD symptoms known in Japan. Although they show KD-like manifestations, we cannot conclude that SARS-CoV-2 has the same etiology of our ‘classic’ KD at the present stage. Full article
(This article belongs to the Special Issue Clinic Research on Kawasaki Disease in Children)
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