Special Issue "Thrombosis and Hemostasis in Children"

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Oncology and Hematology".

Deadline for manuscript submissions: closed (1 February 2021).

Special Issue Editors

Prof. Dr. Manuela Albisetti
E-Mail Website
Guest Editor
Division of Paediatrics and Haematology, University Children’s Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland
Interests: pediatric thrombosis; bleeding disorders
Prof. Paul Monagle
E-Mail Website
Guest Editor
Department of Paediatrics, The University of Melbourne, Royal Children’s Hospital, 50 Flemington Road, Parkville, VIC 3052, Australia
Interests: pediatric thrombosis; anticoagulation; developmental hemostasis

Special Issue Information

Dear Colleagues,

Thromboembolic events in children have dramatically increased in the last decade and have become a major challenging problem in tertiary care settings. These thromboembolic events occur as secondary complications of improved treatment strategies for formal lethal underlying disorders in very young children, the most common risk factor being indwelling central venous or arterial catheters. Thromboembolic events also occur in older children with trauma, surgery, infections, malignancy, intake of oral contraceptives, immobilization, and in the presence of antiphospholipid antibodies or inherited thrombophilia. Increasing evidence suggests that thromboembolic events significantly increase morbidity and mortality of affected children. The epidemiology and pathophysiology of thromboembolic events as well as the hemostatic system in children differ substantially from those in adults. These differences make the application of strategies for the diagnostics, prophylactics, and treatment of thromboembolic events from adults to children not only inappropriate but also dangerous. For this reason, basic and clinical research in children is mandatory in order to advance knowledge of and ultimately to provide optimal, evidence-based care for pediatric thrombosis.

The goal of this Special Issue of Children is to provide new insights into both venous and arterial thromboembolic events from neonates to adolescents. We welcome reviews and original research focusing on the epidemiology, pathophysiology, diagnostic, and treatment modalities, as well as on outcome of thromboembolic events. We also invite manuscripts that highlight gaps in knowledge and the need for international collaboration to pursue the intent of providing well-powered studies in pediatric thrombosis.

Prof. Dr. Manuela Albisetti
Prof. Dr. Paul Monagle
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • thromboembolism
  • venous thrombosis
  • arterial thrombosis
  • children
  • anticoagulation
  • treatment

Published Papers (1 paper)

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Venous Malformations and Blood Coagulation in Children
Children 2021, 8(4), 312; https://0-doi-org.brum.beds.ac.uk/10.3390/children8040312 - 20 Apr 2021
Cited by 1 | Viewed by 541
Introduction: Venous malformations (VMs) are congenital low-flow lesions with a wide spectrum of clinical manifestations. An increasing number of studies link VMs to coagulation abnormalities, especially to elevated D-dimer and decreased fibrinogen. This condition, termed localized intravascular coagulopathy (LIC), may pose a risk [...] Read more.
Introduction: Venous malformations (VMs) are congenital low-flow lesions with a wide spectrum of clinical manifestations. An increasing number of studies link VMs to coagulation abnormalities, especially to elevated D-dimer and decreased fibrinogen. This condition, termed localized intravascular coagulopathy (LIC), may pose a risk for hemostatic complications. However, detailed data on the laboratory variables for coagulation and fibrinolytic activity in VM patients are limited. We addressed this question by systematically analyzing the coagulation parameters in pediatric VM patients. Methods: We included 62 patients (median age 11.9 years) with detailed laboratory tests for coagulation and fibrinolytic activity at a clinically steady phase. We assessed clinical and imaging features of VMs and their correlations with coagulation and fibrinolysis variables using patient records and MRI. Results: D-dimer was elevated in 39% and FXIII decreased in 20% of the patients, as a sign of LIC. Elevated D-dimer and decreased FXIII were associated with large size, deep location, and diffuse and multifocal VMs. FVIII was elevated in 17% of the patients and was associated with small VM size, superficial and confined location, discrete morphology, and less pain. Surprisingly, antithrombin was elevated in 55% of the patients but without associations with clinical or other laboratory variables. Conclusions: LIC was common in pediatric patients with VMs. Our results provide a basis for when evaluating the risks of hemostatic complications in children with VMs. Further research is warranted to explore the mechanisms behind coagulation disturbances and their relation to clinical complications. Full article
(This article belongs to the Special Issue Thrombosis and Hemostasis in Children)
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