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Recent Advances of Stem Cell and Scaffold Interactions in Tissue...
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Recent Advances of Stem Cell and Scaffold Interactions in Tissue Engineering

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 11049

Special Issue Editor

Prof. Dr. Qingsong Ye

E-Mail Website
Guest Editor
Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China
Interests: dental pulp stem cell; regenerative medicine; active biomaterials; nanotechnology; exosome; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent studies have shown that cells could ‘sense’ the surfaces of the scaffolding biomaterials and result in vigorous tissue responses. When it comes to applications in regenerative medicine, it is essential to provide the cells/stem cells with appropriate surface characteristics to guide desired tissue engineering. There are several strategies following this direction: 1) physical surface modifications (e.g., nano-structure, mechanotransduction) to enhance the desired cell reactions; 2) the coatings of chemical stimuli (e.g., drugs, ions) to promote the cell proliferation/differentiation; 3) the coatings of biological stimuli (e.g., growth factors) to increase cell bioactivities, and 4) the combination of any suitable biological/chemical/physical features on the surface of scaffolds for cell-based tissue regeneration.

Despite the importance of knowing how to regenerate tissue with cells/stem cells, it is also important to know ‘why.’ An in-depth understanding of the mechanisms of how those surface characteristics affect the cells and the tissue regeneration will accelerate the tissue remodeling/regeneration progression and minimize the scaffolds versus the host reactions (immune and fibrotic responses).

This Special Issue, entitled “Recent Advances of Stem Cell and Scaffold Interactions in Tissue Engineering,” is dedicated to introducing recent advances in physical, chemical, and biological surface coatings/modulations to stimulate the desired cell reactions thus lead to successful soft-tissue or hard-tissue regeneration. It is with great pleasure that I invite you to submit your excellent work for this Special Issue. Full papers, reviews, and communications are all welcome.

In particular, the topics of interest include but are not limited to:

  1. physical surface modifications (e.g., nano-structure, mechanotransduction) to enhance the desired cell reactions
  2. coatings with chemical stimuli (e.g., drugs, ions) to promote the cell proliferation/differentiation
  3. coatings with biological stimuli (e.g., growth factors) to increase the cell bioactivities
  4. the combination of any of the above biological/chemical/physical features on the surface of scaffolds for cell-based tissue regeneration
  5. 3D printing and additive technologies to create the desired surface characteristics

Prof. Dr. Qingsong Ye
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Tissue engineering
  • Cell-Material interaction
  • Mesoporous silica nanoparticles
  • Dental pulp stem cells
  • Coating and surface characteristics

Published Papers (5 papers)

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Research

9 pages, 2000 KiB  
Article
Platycodin D Alleviates High-Glucose-Aggravated Inflammatory Responses in Oral Mucosal Cells by PI3K/mTOR Pathway
by Bincheng Liu, Yisheng Huang, Zhongjun Liu, Dongjian Li and Junfeng Dao
Coatings 2022, 12(4), 444; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings12040444 - 25 Mar 2022
Cited by 1 | Viewed by 1275
Abstract
Oral mucosal diseases account for an increasing proportion of hμMan diseases. Among the many common risk factors that cause oral diseases and systemic diseases, dietary factors, especially high sugar, are particularly prominent. Exhibiting therapeutic potential in treating certain inflammation-related diseases, platycodin D (PD) [...] Read more.
Oral mucosal diseases account for an increasing proportion of hμMan diseases. Among the many common risk factors that cause oral diseases and systemic diseases, dietary factors, especially high sugar, are particularly prominent. Exhibiting therapeutic potential in treating certain inflammation-related diseases, platycodin D (PD) has been known to possess anti-inflammatory benefits in cases of cytokine-induced inflammation, a fact that has been widely docμMented. However, there are few studies about PD in the oral mucosal disease. Investigating the effect of PD on high-glucose (HG)-induced inflammatory responses in oral mucosal cells was the endeavor of this study. The results revealed that HG induced cell mortality, promoted activity of inflammatory factor (TNF-α, IL-1β, IL-6, and IL-8), and increased ROS production in oral mucosal cells. Interestingly, PD obviously alleviated HG-induced oral mucosal cells inflammatory response. Simultaneously, the expressions of PI3K and mTOR were inhibited by PD. In addition, the activation of PI3K and mTOR decreased the protective effect of PD on oral mucosal cells. To conclude, the PI3K/mTOR signaling pathway was found to be inactivated, thereby restraining the activation of the full immune cell by inhibition of the pro-inflammatory cytokines, as revealed by the results indicating the prevention of the HG-induced inflammation response by PD. Full article
(This article belongs to the Special Issue Recent Advances of Stem Cell and Scaffold Interactions in Tissue Engineering)
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11 pages, 25065 KiB  
Article
Impaired Proliferation, Apoptosis, and Angiogenesis of Adipose-Derived Stem Cells Isolated from Rats during the Course of Diabetes
by Lixia Wen, Peng Liu, Qi Chen, Jiayuan Ge, Bo Jia and Qin Li
Coatings 2021, 11(12), 1549; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11121549 - 17 Dec 2021
Viewed by 1692
Abstract
Background: To characterize the impaired of proliferation, apoptosis, and angiogenic activity in ASCs isolated at different stages of the disease course from rats with type 1 diabetes mellitus (T1DM) rats induced by streptozotocin (STZ). Methods: Adipose tissues of the epididymis were harvested at [...] Read more.
Background: To characterize the impaired of proliferation, apoptosis, and angiogenic activity in ASCs isolated at different stages of the disease course from rats with type 1 diabetes mellitus (T1DM) rats induced by streptozotocin (STZ). Methods: Adipose tissues of the epididymis were harvested at 0, 4, 8, 12, and 16 weeks after the induction of T1DM in rats and from normal rats at the same time points and the morphological variations were detected by Oil red O staining. ASCs were collected from adipose tissues. Cell proliferation, apoptosis, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) expression were assessed. Results: With the prolongation of the disease course, the size and the morphology of adipocytes were distorted, and intracellular lipid droplets became smaller. After 4 weeks, the proliferation of ASCs was decreased, while apoptosis in ASCs was increased. Furthermore, as the disease proceeded, proliferation decreased and apoptosis increased. VEGF and bFGF expression in ASCs from diabetic rats was downregulated at 8 weeks. Conclusion: At 4 weeks after T1DM induction, the proliferation of ASCs decreased and apoptosis increased. The expression of angiogenic factors in ASCs declined at 8 weeks after T1DM induction. The changes in the proliferation, apoptosis, and angiogenic activity are related to the prolongation of disease course. Full article
(This article belongs to the Special Issue Recent Advances of Stem Cell and Scaffold Interactions in Tissue Engineering)
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10 pages, 3715 KiB  
Article
SIRT1 Promotes Osteogenic Differentiation in Human Dental Pulp Stem Cells through Counteracting the Activation of STAT3
by Dan Zhao, Wen Kang, Yiwen Wang, Jiuyu Ge, Jianfeng Huang, Jie Yang, Weidong Yang, Xuna Tang and Sijing Xie
Coatings 2021, 11(11), 1353; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11111353 - 03 Nov 2021
Viewed by 1764
Abstract
Human dental pulp stem cells (hDPSCs), which are characterized by self-renewal capacity and the ability of multilineage differentiation, have gained increased attention in regenerative medicine recently. Histone acetylation modulator proteins (HAMPs) are a protein family that mediates the modification and identification of histone [...] Read more.
Human dental pulp stem cells (hDPSCs), which are characterized by self-renewal capacity and the ability of multilineage differentiation, have gained increased attention in regenerative medicine recently. Histone acetylation modulator proteins (HAMPs) are a protein family that mediates the modification and identification of histone acetylation and participates in various critical cellular processes. Here, we comprehensively surveyed the expression profile of HAMPs during osteoblast differentiation of hDPSCs and found that the HDAC class III pathway was upregulated, whereas the signal transducer and activator of transcription 3 (STAT3) signaling was downregulated during osteogenesis. Further laboratory research demonstrated that Sirtuin-1 (SIRT1), a class III HDAC, was upregulated and STAT3 activation was downregulated during osteogenic differentiation. SIRT1 counteracted the activation of STAT3 to promote osteogenic differentiation of hDPSCs at 7 and 21 days in both Western blot assay and chemical staining, which highlights the promising utility of SIRT1 activators in hDPSCs-based therapies for bone augmentation strategies and provides clinical insights that may lead to the development of osteogenic agents. Full article
(This article belongs to the Special Issue Recent Advances of Stem Cell and Scaffold Interactions in Tissue Engineering)
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12 pages, 2832 KiB  
Article
Hierarchical Two-Dimensional Layered Double Hydroxide Coated Polydopamine Nanocarriers for Combined Chemodynamic and Photothermal Tumor Therapy
by Prabhakar Busa, Ravindranadh Koutavarapu, Dong-Yeon Lee, Jaesool Shim and Yaswanth Kuthati
Coatings 2021, 11(8), 1008; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11081008 - 23 Aug 2021
Cited by 6 | Viewed by 3048
Abstract
The combination of chemodynamic therapy (CDT) and photothermal therapy (PTT) has proven to be successful in combating the challenges associated with cancer therapy. A combination of these therapies can maximize the benefits of each therapeutic modality through endogenous reduction-oxidation (redox) reaction and external [...] Read more.
The combination of chemodynamic therapy (CDT) and photothermal therapy (PTT) has proven to be successful in combating the challenges associated with cancer therapy. A combination of these therapies can maximize the benefits of each therapeutic modality through endogenous reduction-oxidation (redox) reaction and external laser power induction. In the current work, we have designed a copper-aluminum layered double hydroxide (CuAl-LDH) loaded doxorubicin (DOX) by a co-precipitation method; the surface was coated with polydopamine (PDA). The synthesized CuAl-LDH@DOX@PDA nanocarrier (NC) served as a Fenton-like catalyst with photothermal properties. It is well known that metal ion incorporated NCs can induce intracellular depletion of reduced glutathione (GSH) levels along with the reduction of Cu2+ to Cu+. The Cu+ ions in turn react with DOX leading to the generation of intracellular hydrogen peroxide (H2O2) molecules to produce the highly toxic hydroxyl radicals (•OH) through a Fenton-like reaction. The enhanced absorption of CuAl@DOX@PDA at 810 nm, greatly improved the photothermal efficiency in comparison with bare CuAl-LDH and CuAl-LDH@DOX. In vitro studies revealed the tremendous CDT/PTT efficacy of CuAl@DOX@PDA in suppressing A549 cancer cells. Furthermore, reactive oxygen species (ROS) assays and intracellular levels of various ROS cascade biomolecules support our findings in the efficient destruction of cancer cells through synergistic CDT/PTT therapy. Full article
(This article belongs to the Special Issue Recent Advances of Stem Cell and Scaffold Interactions in Tissue Engineering)
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12 pages, 9560 KiB  
Article
Biomechanical Interfaces of Corticotomies on Periodontal Tissue Remodeling during Orthodontic Tooth Movement
by Ruojing Liu, Li Huang, Xiaoyue Xiao, Yuzhe Guan, Yukun Jiang, Xing Yin, Shujuan Zou and Qingsong Ye
Coatings 2021, 11(1), 1; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11010001 - 22 Dec 2020
Cited by 25 | Viewed by 2342
Abstract
Corticotomy is an effective approach in accelerating orthodontic tooth movement (OTM) in clinical treatment. Corticotomy causes regional acceleratory phenomenon (RAP) in the alveolar bone of surgical sites. However, the molecular mechanism of RAP after corticotomy remains unclear. Herein, we established a mouse model [...] Read more.
Corticotomy is an effective approach in accelerating orthodontic tooth movement (OTM) in clinical treatment. Corticotomy causes regional acceleratory phenomenon (RAP) in the alveolar bone of surgical sites. However, the molecular mechanism of RAP after corticotomy remains unclear. Herein, we established a mouse model to study the biomechanical interfaces of corticotomy-assisted OTM and to investigate the histological responses and underlying cellular mechanism. A total of 144 male C57BL/6 mice were randomly assigned into four groups: corticotomy alone (Corti), sham operation (Sham), corticotomy with tooth movement (Corti + TM), and sham operation with tooth movement (Sham + TM). Nickel–titanium orthodontic springs were applied to trigger tooth movement. Mice were sacrificed on Post-Surgery Day (PSD) 3, 7, 14, 21, and 28 for radiographic, histological, immunohistochemical, and molecular biological analyses. The results reveal that corticotomy significantly promoted alveolar bone turnover and periodontal tissue remodeling. During orthodontic tooth movement, corticotomy significantly promoted osteogenic and proliferative activity, accelerated tooth movement, and eliminated root resorption by upregulating Wnt signal pathway. Full article
(This article belongs to the Special Issue Recent Advances of Stem Cell and Scaffold Interactions in Tissue Engineering)
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