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Oral and Maxillofacial Surgery: Latest Advances and Prospects

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A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Oral and Maxillofacial Surgery".

Deadline for manuscript submissions: closed (10 June 2023) | Viewed by 23005

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Special Issue Editors

Dr. Kenji Yamagata

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Guest Editor

Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Interests: oral cancer; orthognathic surgery; cleft lip and palate; implantology; traumatology
Special Issues, Collections and Topics in MDPI journals

Dr. Satoshi Fukuzawa

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Guest Editor

Special Issue Information

Dear Colleagues,

In the field of oral and maxillofacial surgery, surgical techniques and devices, the surgical planning method with computer-assisted surgery (CAS), and the perioperative management of patients with basal disease have undergone rapid progress over the last few decades.

For example, the treatment results of patients with oral cancer can be improved through surgery with wide resection and reconstruction, and chemoradiotherapy. A new molecular target drug and immune checkpoint inhibiter were found to prolong survival after recurrence and distant metastasis recently. Moreover, in the field of orthognathic surgery, the CAS is usually widely performed all over the world from surgical planning and precise surgery.

This Special Issue will publish new information on the oral and maxillofacial surgery, including the latest advances and prospects on all fields of oral and maxillofacial surgery. Clinical and basic articles and reviews are welcome for submission.

Dr. Kenji Yamagata
Dr. Satoshi Fukuzawa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oral cancer
orthognathic surgery
cleft lip and palate
implantology
traumatology

Published Papers (7 papers)

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Research

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12 pages, 3093 KiB

Open AccessArticle

Salivary Duct Carcinoma with Rhabdoid Features of the Parotid Gland with No E-Cadherin Expression: A Report with Anti-HER2 Therapy and Review of the Literature

by Richa Jain, E. Ritter Sansoni, Jacqueline Angel, John P. Gleysteen, D. Neil Hayes and Adepitan A. Owosho

Dent. J. 2023, 11(10), 229; https://0-doi-org.brum.beds.ac.uk/10.3390/dj11100229 - 25 Sep 2023

Viewed by 1480

Abstract

Salivary duct carcinoma with rhabdoid features (SDC-RF) is a rare form of salivary gland neoplasm that was recently described. We report a case of SDC-RF of the parotid gland with loss of E-cadherin and decreased β-catenin expression in a 73-year-old male who presented with right facial/neck swelling and intermittent pain. Morphologically, the tumor presented with a discohesive infiltrate of isolated and cords of pleomorphic round cells containing moderate amount of eosinophilic to fine-vacuolated cytoplasm and hyperchromatic nuclei infiltrating through fibroadipose tissue and salivary parenchyma. Immunophenotypically, the tumor was positive for Cytokeratins Oscar and 7, GATA3, GCDFP, HER2, and an androgen receptor but negative for CK20, S100, p40, Melan A, CDX2, TTF1, ER, SATB2, DOG1, synaptophysin, and chromogranin. Due to its diffuse infiltrating pattern, involvement of the parapharyngeal space, supraclavicular fat pad, dermis, and skin without a defined surgical target, the tumor was deemed unresectable. Anti-HER2 therapy (Herceptin and Pertuzumab) was utilized. At the last follow-up, the patient is alive, with complete locoregional control and brain metastases. An electronic search was performed in the following registries for papers published up to June 2023: PubMed, Embase, and Web of Science. For the database searches, the keywords searched were “salivary gland”, “salivary duct carcinoma”, and “salivary duct carcinoma with rhabdoid features”. Our review of the literature identified 30 cases of SDC-RF that reveal there is a predilection for males (83%), parotid gland (72%), and patients older than the 6th decade of life (83%). Immunophenotypically, all SDC-RF cases except one were positive for AR and GCDFP (97%), 81% were positive for HER2, and loss or decreased expression of E-cadherin in 93% of cases. In conclusion, we described a rare case of SDF-RF of the parotid gland with no E-cadherin expression, decreased β-catenin expression, and its immunophenotypic profile. Full article

(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Latest Advances and Prospects)

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10 pages, 4600 KiB

Open AccessArticle

Novel Three-Dimensional and Non-Invasive Diagnostic Approach for Distinction between Odontogenic Keratocysts and Ameloblastomas

by Juergen Taxis, Natascha Platz Batista da Silva, Elisabeth Grau, Gerrit Spanier, Felix Nieberle, Michael Maurer, Steffen Spoerl, Johannes K. Meier, Tobias Ettl, Torsten E. Reichert and Nils Ludwig

Dent. J. 2023, 11(8), 193; https://0-doi-org.brum.beds.ac.uk/10.3390/dj11080193 - 11 Aug 2023

Viewed by 1010

Abstract

Aim of this study was to demonstrate the diagnostic ability to differentiate odontogenic keratocysts (OKCs) from ameloblastomas (AMs) based on computed tomography (CT) or cone beam computed tomography (CBCT) scans. Preoperative CT and CBCT scans from 2004 to 2019 of OKCs and AMs were analyzed in 51 participants. Lesions were three-dimensionally (3D) assessed and Hounsfield units (HU) as well as gray scale values (GSV) were quantified. Calculated HU spectra were compared within the same imaging modalities using unpaired t-tests and correlated with participants characteristics by calculating Pearsons correlation coefficients. Within the CT scans, AMs had highly significantly higher HU values compared to OKCs (43.52 HU and 19.79 HU, respectively; p < 0.0001). Analogous, within the CBCT scans, AMs had significantly higher GSV compared to OKCs (−413.76 HU and −564.76 HU, respectively; p = 0.0376). These findings were independent from participants’ gender and age, anatomical site, and lesion size, indicating that the HU- and GSV-based difference reflects an individual configuration of the lesion. HU and GSV spectra calculated from CT and CBCT scans can be used to discriminate between OKCs and AMs. This diagnostic approach represents a faster and non-invasive option for preoperative diagnosis of such entities and has potential to facilitate therapeutic decision making. Full article

(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Latest Advances and Prospects)

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Graphical abstract

12 pages, 3509 KiB

Open AccessArticle

Surgical Treatment in Patients with Toxic Phosphorus Osteonecrosis of Facial Skull Middle Zone

by Davit H. Ispiryan, Gagik Hakobyan, Anastasia Li, Ekaterina Yu. Diachkova, Yuriy Vasil’ev, Artur Kheygetyan, Elena Ivanova, Kirill Zhandarov, Natalia Kireeva, Roman Safronov, Alexey Serikov and Yuri A. Medvedev

Dent. J. 2023, 11(5), 108; https://0-doi-org.brum.beds.ac.uk/10.3390/dj11050108 - 23 Apr 2023

Cited by 1 | Viewed by 1311

Abstract

During the last few years, in the territory of the Russian Federation, the number of cases of toxic phosphoric osteonecrosis of the jaws has increased against the background of taking drugs of “artisanal” production (pervitin, desomorphin). The aim of our study was to increase the effectiveness of surgical treatment of patients with a diagnosis of toxic phosphorus necrosis of the maxilla. We performed a comprehensive treatment of patients with a history of drug addiction and the above diagnosis. Surgical intervention in the volume of complete resection of pathologically altered tissues and reconstructive techniques using local tissues and a replaced flap made it possible to achieve good aesthetic and functional results in the early and late postoperative period. Thus, our proposed method of surgical treatment can be used in similar clinical situations. Full article

(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Latest Advances and Prospects)

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9 pages, 1046 KiB

Open AccessArticle

Convenient Decision Criteria for Surgery in Elderly Patients with Oral Squamous Cell Carcinoma

by Ryo Takasaki, Kenji Yamagata, Satoshi Fukuzawa, Fumihiko Uchida, Naomi Ishibashi-Kanno and Hiroki Bukawa

Dent. J. 2023, 11(1), 6; https://0-doi-org.brum.beds.ac.uk/10.3390/dj11010006 - 26 Dec 2022

Viewed by 2255

Abstract

Elderly patients with oral squamous cell carcinoma (OSCC) have difficulty undergoing curative surgical treatment due to various factors besides age. The purpose of the present study was to study the factors determining surgery in elderly patients with OSCC. We designed and implemented a retrospective cohort study. The study sample included elderly patients aged ≥ 70 years with OSCC and they were statistically compared between the surgery and non-surgery groups. The primary outcome variable was selecting surgery as the treatment plan, while the secondary outcome was the prognosis of each group. The sample comprised 76 patients aged ≥ 70 years with OSCC, of whom 52 treated with surgery and 24 patients treated with non-surgery. As decision factors, performance status (PS), clinical stage, serum Alb level, body mass index (BMI), and Geriatric Nutritional Risk Index (GNRI) were significantly associated with the selection of surgery. Logistic multivariate analysis identified three independent predictive factors for selecting surgery: Alb (≥3.5 vs. <3.5), PS (0, 1, 2, 3), and clinical stage. According to the decision tree analysis, curative surgery is the recommended treatment strategy for elderly patients with Alb ≥ 3.5 g/dL, PS 0, and stage I, II. In conclusion, Alb, PS, and clinical stage may be the criteria for selecting surgery in elderly patients. Full article

(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Latest Advances and Prospects)

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Other

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14 pages, 9590 KiB

Open AccessCase Report

Mandibular Reconstruction after Resection of Ameloblastoma by Custom-Made CAD/CAM Mandibular Titanium Prosthesis: Two Case Reports, Finite Element Analysis and Discussion of the Technique

by Antonio Cortese, Francesca Spirito, Pier Paolo Claudio, Lorenzo Lo Muzio, Alessandro Ruggiero and Maurizio Gargiulo

Dent. J. 2023, 11(4), 106; https://0-doi-org.brum.beds.ac.uk/10.3390/dj11040106 - 20 Apr 2023

Cited by 2 | Viewed by 2410

Abstract

Virtual surgical planning for CAD/CAM mandibular reconstruction by titanium prosthesis was recently reported for resected cases. Even if some advantages are evident, difficulties that may arise for TMJ function after reconstruction originate from prosthesis contamination through oral mucosa dehiscence. In these two cases reported of mandibular reconstruction after resection of ameloblastoma by custom-made CAD/CAM titanium prosthesis, the procedures were aimed to preserve the TMJ glenoid cavity and articular disc avoiding functional problems for hemi-mandibular resections that included the condyle (as in case #1) or with condylar preservation (as in case #2) and avoiding intraoral incisions in both cases. The entire surgical planning and prosthetic fabrication were explained with specifications and the sequence of the surgical procedure. Finite elements analysis (FEA) was performed to check the force distribution and efficacy of the prosthetic device (case 1 with hemi-mandibular resection and rehabilitation). Although successful in these two cases, surgical reconstruction of the mandibular defect after resection by a CAD-CAM custom-made prosthesis still shows some drawbacks and failure risks. Several advantages of this technique and the surgical success in these two cases were presented, but limitations and side effects must be considered when cases are selected. Full article

(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Latest Advances and Prospects)

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9 pages, 2531 KiB

Open AccessCase Report

Successful Treatment of Myofascial Pain Syndrome (MPS) with Surgical Cauterization of Temporalis Muscle Trigger Points: A Case Report

by Craig Pearl, Brendan Moxley, Andrew Perry and Nagi Demian

Dent. J. 2023, 11(1), 3; https://0-doi-org.brum.beds.ac.uk/10.3390/dj11010003 - 23 Dec 2022

Cited by 1 | Viewed by 3245

Abstract

For patients suffering from myofascial pain syndrome (MPS) affecting muscles of mastication, traditional trigger point therapy treatment regimens can prove inconvenient, due to the short duration of pain relief after each injection and expense of repeated visits which are often not covered by insurance. We present a case of a patient treated using an alternative technique that could develop into an additional modality for treating MPS patients who are refractory to conservative treatment. This technique involves identifying and marking the patient’s trigger points and surgically cauterizing each location using a Bovie electrosurgical unit. While traditional trigger point injection therapy for myofascial pain syndrome is a well-described technique with acceptable pain relief expected for a period of 8–12 weeks, this technique provided up to 24 months of adequate pain relief in a patient. While further studies are indicated before widespread adoption can be recommended, this patient’s response suggests that this technique may be useful in offering longer-term pain relief compared with trigger point injection therapy. Full article

(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Latest Advances and Prospects)

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9 pages, 3184 KiB

Open AccessCase Report

Management of Trigeminal Neuralgia with Botulinum Toxin Type A: Report of Two Cases

by Craig Pearl, Brendan Moxley, Andrew Perry, Nagi Demian and Cyndie Dallaire-Giroux

Dent. J. 2022, 10(11), 207; https://0-doi-org.brum.beds.ac.uk/10.3390/dj10110207 - 03 Nov 2022

Cited by 3 | Viewed by 10301

Abstract

Trigeminal neuralgia is a chronic pain condition associated with sharp, shock-like pain in one or more divisions of the trigeminal nerve. For patients who do not respond well to pharmacotherapy, there is growing evidence that Botulinum toxin type A injections into the trigeminal ganglion provide pain relief for several weeks up to several months at a time. One option is to administer injections into the trigeminal ganglion in Meckel’s cave by inserting a needle through the Pterygopalatine Fossa using fluoroscopy to guide and confirm the proper needle placement. However, there is evidence that Botulinum toxin travels across nerve synapses; thus, injecting directly into the trigeminal ganglion may not be necessary. We present two patients with a confirmed diagnosis of trigeminal neuralgia who were treated by injecting Botulinum toxin type A intraorally into the mental foramen which resulted in 6 months or longer of pain relief. Injections into the mental foramen are much easier to administer than those administered directly into the trigeminal ganglion, and both patients treated with this technique experienced comparable results to what can be expected from traditional fluoroscopy-guided botulinum toxin injections. Though more research is needed, these cases potentially imply that a less-invasive injection may be sufficient in managing trigeminal neuralgia-related pain. Full article

(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Latest Advances and Prospects)

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