Gels from the Self-Assembling of Peptide-Based Compounds 2.0

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 7148

Special Issue Editor


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Special Issue Information

Dear Colleagues,

A great number of applications are, nowadays, derived from the self-assembly of peptide-based materials. Basically, peptides have peculiar features derived from the presence of amide groups able to establish strong intermolecular hydrogen-bonding interactions and side-chain groups able to render a highly variable functionality.

The self-assembling of low molecular weight peptides can lead to new hydrogels, which can be considered as protein-mimetic materials. Therefore, specific characteristics such as responsiveness, functionality and structural versatility can be expected, opening an immense field of cutting-edge applications. The low molecular weight of peptides gives rise to interesting characteristics as an easy synthesis and purification together with a high capacity to tune the final properties of materials. Nevertheless, it is still difficult to achieve the great efficiency of proteins since these have followed a process of natural selection during the evolution of the species.

This Special Issue of Gels aims to discuss, collect and offer recent highlights and advances on gels derived from the self-assembling of peptides. To this end, the progress on the development of self-assembling peptide compounds, the study of their structural organization, the evaluation of the responsiveness under different external stimuli (i.e., pH, temperature, concentration, intermolecular non-covalent interactions) and the study of applications in biomedicine, catalysis and materials science are some of the specific topics that should be considered.

Prof. Dr. Jordi Puiggalí
Guest Editor

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Published Papers (2 papers)

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Research

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15 pages, 2581 KiB  
Article
Metal Cation Triggered Peptide Hydrogels and Their Application in Food Freshness Monitoring and Dye Adsorption
by Anna Fortunato and Miriam Mba
Gels 2021, 7(3), 85; https://0-doi-org.brum.beds.ac.uk/10.3390/gels7030085 - 07 Jul 2021
Cited by 20 | Viewed by 3050
Abstract
Metal-ligand interactions have emerged as an important tool to trigger and modulate self-assembly, and to tune the properties of the final supramolecular materials. Herein, we report the metal-cation induced self-assembly of a pyrene–peptide conjugate to form hydrogels. The peptide has been rationally designed [...] Read more.
Metal-ligand interactions have emerged as an important tool to trigger and modulate self-assembly, and to tune the properties of the final supramolecular materials. Herein, we report the metal-cation induced self-assembly of a pyrene–peptide conjugate to form hydrogels. The peptide has been rationally designed to favor the formation of β-sheet 1D assemblies and metal coordination through the Glu side chains. We studied in detail the self-assembly process in the presence of H+, Li+, Na+, K+, Ca2+, Ni2+, Cu2+, Zn2+, Cd2+, Co2+, Fe3+, and Cr3+ and found that the morphology and mechanical properties of the hydrogels are ion-dependent. Moreover, thanks to the presence of the metal, new applications could be explored. Cu2+ metallogels could be used for amine sensing and meat freshness monitoring, while Zn2+ metallogels showed good selectivity for cationic dye adsorption and separation. Full article
(This article belongs to the Special Issue Gels from the Self-Assembling of Peptide-Based Compounds 2.0)
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Review

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14 pages, 2311 KiB  
Review
Peptide Gelators to Template Inorganic Nanoparticle Formation
by Ottavia Bellotto, Maria C. Cringoli, Siglinda Perathoner, Paolo Fornasiero and Silvia Marchesan
Gels 2021, 7(1), 14; https://0-doi-org.brum.beds.ac.uk/10.3390/gels7010014 - 02 Feb 2021
Cited by 18 | Viewed by 3466
Abstract
The use of peptides to template inorganic nanoparticle formation has attracted great interest as a green route to advance structures with innovative physicochemical properties for a variety of applications that range from biomedicine and sensing, to catalysis. In particular, short-peptide gelators offer the [...] Read more.
The use of peptides to template inorganic nanoparticle formation has attracted great interest as a green route to advance structures with innovative physicochemical properties for a variety of applications that range from biomedicine and sensing, to catalysis. In particular, short-peptide gelators offer the advantage of providing dynamic supramolecular environments for the templating effect on the formation of inorganic nanoparticles directly in the resulting gels, and ideally without using further reductants or chemical reagents. This mini-review describes the recent progress in the field to outline future research directions towards dynamic functional materials that exploit the synergy between supramolecular chemistry, nanoscience, and the interface between organic and inorganic components for advanced performance. Full article
(This article belongs to the Special Issue Gels from the Self-Assembling of Peptide-Based Compounds 2.0)
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