Decoding the Genomic Evolution of Pathogenic Eukaryotes Through Integrated Multi-Omics Approaches

Dear Colleagues,

Global initiatives, such as The Earth BioGenome Project (EBP), are working to expand and accelerate the development of genomic resources encompassing all extant eukaryotes. Advances in high-throughput sequencing technologies, coupled with robust computational and machine learning approaches, are revolutionizing our understanding of molecular mechanisms that drive the diversification of life.

At the core of EBP's mission lies a key objective: enhancing our understanding of eukaryotic pathogen biology and mechanisms that underlie acquisition of virulence. Comparative genomics allows us to pinpoint critical moments and events in evolutionary trajectories revealing the adaptive strategies used by eukaryotic pathogens in response to interactions with host organisms and the environment.

In this Special Issue, we invite scholarly contributions, including review articles and original research, that focus on exploring the evolution of eukaryotic pathogens. Emphasis should be placed on harnessing the potential of multi-omic technologies and innovative tools capable of capturing changes in the genomic architecture, as well as precisely tracking fluctuations in transcriptomic, proteomic, epigenomic, and metabolomic perturbations. Undoubtedly, the insights derived from these technologies will significantly enrich our understanding of infectious diseases and open new avenues for solutions in public health and agriculture.

Dr. Dinah Qutob
Prof. Dr. Adam C. Underwood
Guest Editors

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• coevolution
• phylogenomics
• effectors/secretome
• epigenetics
• non-vertical transmission
• evolutionary drivers
• host–pathogen dynamics
• drug resistance
• antigenic variation