Dear Colleagues,

The rate of infertility is rising worldwide, with the latest data from a recent report, published by the WHO earlier in 2023, stating that the lifetime prevalence of infertility in the adult population is 17.5%, which roughly equates to around 1 in 6 people globally having experienced infertility at some stage in their lives. The rapidly evolving advancements in the science and expertise dedicated to assisted reproductive technologies should aim to target the challenges that this data brings about, especially with the increasing trend in the modern world of people seeking fertility at an older age. Updates in individualizing ovarian stimulation treatment protocols, gamete donation programs, treatment of endometriosis and advancements in the management of uterine factors including adenomyosis, are classic examples, whilst newer concepts include the paternal contribution and the role of epigenetics towards embryo development, and ovarian rejuvenation techniques. The scope of this Special Issue is to provide a homogeneity of data and updated evidence which can be used by clinicians and laboratory scientists worldwide to improve the clinical reproductive outcomes of an increasingly infertile population. Researchers in these fields of reproductive medicine are encouraged to submit original articles or reviews to this Special Issue (excluding case reports and short reviews).

Dr. Mauro Cozzolino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• adenomyosis
• endometriosis
• egg donation
• individualized ovarian stimulation protocols
• ovarian rejuvenation
• male factor infertility