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Clinical Management of Skin Infections
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Clinical Management of Skin Infections

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Infectious Diseases".

Deadline for manuscript submissions: closed (18 September 2023) | Viewed by 8350

Special Issue Editor

Prof. Dr. Lin Ma

E-Mail Website
Guest Editor
Department of Dermatology, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, Beijing, China
Interests: basic research and long-term management of atopic dermatitis/eczema; research and comprehensive treatment of cutaneous hemangioma and vascular diseases in children; diagnosis and treatment of infectious skin diseases; laser treatment of abnormal skin in children; comprehensive treatment of hereditary skin diseases

Special Issue Information

Dear Colleagues,

Clinical skin and soft tissue infections are very common and involve many disciplines. Due to the structural and functional characteristics of the skin itself, the diseases caused by its infection are more complex, involving not only common infections such as those caused by viruses, bacteria and fungi, but also some rare pathogenic infections. In recent years, with the aging of the population and changes in lifestyle, as well as the deepening of relevant basic and clinical research, the mode of skin and soft tissue infections has changed. The occurrence of classic skin and soft tissue infections is higher than ever before. Skin and soft tissue infections are even more common than diabetes, AIDS and other conditions, and bacterial-resistant and rare bacterial infections are also prominent. In particular, the status of community-acquired methicillin-resistant Staphylococcus (CA-MRSA) and other drug-resistant bacteria should not be ignored. As MRSA and other drug-resistant bacteria in the skin may become an important source of systemic infection, it is necessary to strengthen the monitoring of this aspect and introduce targeted prevention and treatment measures. In conclusion, infectious dermatosis is a common and challenging problem faced by dermatologists. In clinical work, paying attention to the role of infection in the occurrence of diseases is important to improve the level of prevention and treatment of skin diseases.

This Special Issue aims to provide new information pertaining to the etiology, examination and treatment of various skin and soft tissue infections. It will also focus on the monitoring, prevention and treatment of drug-resistant bacteria (including MRSA).

Prof. Dr. Lin Ma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial infectious dermatosis
  • fungal infectious dermatosis
  • viral dermatosis
  • rare skin infections
  • monitoring of drug-resistant bacteria

Published Papers (4 papers)

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Research

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12 pages, 1008 KiB  
Article
Clinical-Epidemiological Characteristics of Hidradenitis Suppurativa: A Retrospective Cohort Study from a Tertiary Care Centre in Northern Israel
by Anan Hammud, Emily Avitan-Hersh and Ziad Khamaysi
J. Clin. Med. 2023, 12(12), 3921; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm12123921 - 08 Jun 2023
Viewed by 1028
Abstract
Background: Hidradenitis suppurativa (HS) is characterised by inflamed lesions that typically appear in apocrine-rich flexural areas. Although studies have reported clinical and epidemiological data from western countries, data from the Middle East are scarce. The aim of this study is to characterise the [...] Read more.
Background: Hidradenitis suppurativa (HS) is characterised by inflamed lesions that typically appear in apocrine-rich flexural areas. Although studies have reported clinical and epidemiological data from western countries, data from the Middle East are scarce. The aim of this study is to characterise the differences in the clinical characteristics of patients with HS of Arab and Jewish ancestry and review the clinical characteristics, the course of the disease, the comorbidities, and the response to treatment. Methods: This is a retrospective study. We collected clinical and demographic data from patient files between 2015–2018 at the Rambam Healthcare Campus dermatology clinic—a tertiary hospital located in the north of Israel. Our results were compared to those of a previously published Israeli control group registered in Clalit Health Services. Results: Of the 164 patients with HS, 96 (58.5%) were men and 68 (41.5%) were women. The average age at diagnosis was 27.5 years and the average latency between the onset and diagnosis of the disease was 4 years. We found a higher adjusted prevalence of HS in Arab patients (56%) than in their Jewish counterparts (44%). Gender, smoking, and obesity, as well as axilla and buttock lesions, were risk factors for severe HS, with no differences between ethnicities. No differences were documented in comorbidities and in response to adalimumab, with a high overall response rate of 83%. Conclusions: Our findings revealed differences between Arab and Jewish patients with HS in terms of incidence and gender predominance, while no differences were documented in comorbidities and response to adalimumab. Full article
(This article belongs to the Special Issue Clinical Management of Skin Infections)
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13 pages, 5729 KiB  
Article
Experimental Phaeohyphomycosis of Curvularia lunata
by Najwa Al-Odaini, Kai-su Pan, Liu-wei Liao, Nan-fang Mo, Zhi-wen Jiang, Tian-tian Li, Xiu-ying Li, Xiao-juan He, Dong-yan Zheng and Cun-wei Cao
J. Clin. Med. 2022, 11(18), 5393; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm11185393 - 14 Sep 2022
Cited by 4 | Viewed by 1437
Abstract
Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, [...] Read more.
Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, BALB/c mice were experimentally inoculated with C. lunata suspension by different routes and the course of infection was evaluated. In addition, the in vitro antifungal susceptibility of C. lunata against six commonly used antifungals was evaluated using the microdilution method. Inoculation resulted in skin lesions in animals inoculated intraperitonially and subcutaneously. Infection was confirmed by both mycological and histopathologic examination. C. lunata spores and hyphae were detected in the histopathologic sections stained with hexamine silver staining. In addition, voriconazole (VRC) demonstrated greater activity against C. lunata when compared to the other antifungals, whereas fluconazole (FLC) was the least active antifungal with a minimum inhibitory concentration (MIC) range of 8–16 μg/mL. Further studies are necessary to understand the pathogenicity of C. lunata and uncover the mystery of this fungus. Full article
(This article belongs to the Special Issue Clinical Management of Skin Infections)
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Review

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12 pages, 831 KiB  
Review
Skin Manifestation of Human Monkeypox
by Xue Wang and Wenhui Lun
J. Clin. Med. 2023, 12(3), 914; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm12030914 - 24 Jan 2023
Cited by 8 | Viewed by 3145
Abstract
Monkeypox is a zoonotic infectious disease caused by the monkeypox virus (MPXV) infection, which is mainly manifested as characteristic rashes. It spreads mainly through direct skin-to-skin contact. In some cases, respiratory transmission occurs through contact with respiratory droplets when in close contact with [...] Read more.
Monkeypox is a zoonotic infectious disease caused by the monkeypox virus (MPXV) infection, which is mainly manifested as characteristic rashes. It spreads mainly through direct skin-to-skin contact. In some cases, respiratory transmission occurs through contact with respiratory droplets when in close contact with an infected person for a long time. The monkeypox outbreak in 2022 frequently occurred in the MSM (men who have sex with men) population, raising concerns about whether monkeypox could be transmitted through sexual behavior. This article mainly reviews the research progress of skin manifestations of monkeypox, including typical and atypical rashes of monkeypox, and different skin manifestations in some special groups, such as children, pregnant women and individuals co-infected with HIV (human immunodeficiency virus) and MPXV. At present, dermatologists are not very familiar with the diagnosis and treatment of monkeypox, it is therefore necessary to review the skin manifestations of monkeypox, which can help clinicians diagnose the sporadic cases and monitor the occurrence of monkeypox early, particularly in people at higher risk of infection. Early clinical diagnosis and treatment can largely avoid serious complications and death from monkeypox. Full article
(This article belongs to the Special Issue Clinical Management of Skin Infections)
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Other

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7 pages, 3518 KiB  
Case Report
Takayasu Arteritis Coexisting with Cutaneous Leishmaniasis
by Mutong Zhao, Ying Liu, Zhihai Hu, Juan Sun, Zhou Yang, Li Wei, Zigang Xu and Lin Ma
J. Clin. Med. 2023, 12(5), 1819; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm12051819 - 24 Feb 2023
Viewed by 1183
Abstract
Takayasu arteritis (TA) is a rare large-vessel vasculitis that can result in significant morbidity and mortality. The coexistence of TA with leishmaniasis infection has not been reported previously. Case description: An 8-year-old girl presented with recurrent skin nodules that heal spontaneously for four [...] Read more.
Takayasu arteritis (TA) is a rare large-vessel vasculitis that can result in significant morbidity and mortality. The coexistence of TA with leishmaniasis infection has not been reported previously. Case description: An 8-year-old girl presented with recurrent skin nodules that heal spontaneously for four years. Her skin biopsy revealed granulomatous inflammation with Leishmania amastigotes identified in the histocyte cytoplasm and the extracellular space. The diagnosis of cutaneous leishmaniasis was made and intralesional sodium antimony gluconate was started. One month later, she experienced dry coughs and fever. The CT angiography of the carotid arteries showed dilation in the right common carotid artery and thickening of artery walls with elevated acute phase reactants. The diagnosis of Takayasu arteritis (TA) was made. Reviewing her chest CT before treatment, a soft-tissue density mass was identified in the right carotid artery region, suggesting a pre-existing aneurysm. The patient was treated with surgical resection of the aneurysm with systemic corticosteroids and immunosuppressants. Her skin nodules resolved with scars after the second cycle of antimony while a new aneurysm arose due to a lack of control of TA. Conclusions: This case highlights that benign as the natural course is for cutaneous leishmaniasis, fatal comorbidities can occur as a consequence of chronic inflammation, and can be aggravated by the treatment. Full article
(This article belongs to the Special Issue Clinical Management of Skin Infections)
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