Pathogenesis, Diagnosis, and Management of Upper Gastrointestinal Disease

Dear Colleagues,

In the field of upper gastrointestinal disorders, with the remarkable progress in endoscopy and the discovery of H. pylori, morphological diagnosis, pharmacological treatment, and endoscopic treatment have made great progress in benign and malignant diseases. For this reason, it may even be thought that research and development in this area are no longer necessary. However, in reality, lesions and diseases that cannot be seen with the naked eye or endoscopically remain latent. Regarding functional gastrointestinal disorders without organic disease (e.g., FGIDs and DGBI), eosinophilic esophagitis, eosinophilic gastritis, autoimmune gastritis, and even esophageal motility disorders such as achalasia and jackhammer esophagus, there are many unresolved questions. From this point of view, pathological research with regard to the susceptibility to diseases of the upper gastrointestinal tract, paying attention to the brain–gut interaction and the cooperative relationship with the gastrointestinal luminal environment (gastrointestinal microbiota, dietary factors, etc.), as well as genetic analysis using multilayer omics, etc., it is necessary to establish diagnostics that make full use of microbial flora analysis or artificial intelligence. It is also necessary to establish highly specific and targeted molecular therapeutics.

In this Special Issue, we would like to see new attempts to boldly tackle various problems in the upper gastrointestinal tract from multiple angles.

Prof. Dr. Hidekazu Suzuki
Guest Editor

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• esophagus
• stomach
• duodenum
• DGBI
• FGIDs
• Helicobacter
• eosinophilic esophagitis