Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
3.9
Journals
JCM
Special Issues
Application and Development of OCT Imaging in the Analysis of...
share announcement

Application and Development of OCT Imaging in the Analysis of the Lacrimal System and Ocular Surface Epithelia

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (25 September 2022) | Viewed by 5668

Special Issue Editor

Dr. Pietro Emanuele Napoli

E-Mail Website
Guest Editor
Department of Surgical Science, Università degli studi di Cagliari, 09124 Cagliari, CA, Italy
Interests: eye diseases; imaging; ocular surface; glaucoma; retina; dry eye; optical coherence tomography

Special Issue Information

Dear Colleagues,

Over the past 20 years, OCT imaging has shown its great potential in improving our knowledge on many aspects of ocular physiology and pathophysiology. The ocular surface and tear film can also be analyzed, directly or indirectly, through this precious diagnostic tool. 

In general, the results of a treatment strongly depend on the ability to diagnose and characterize a disease. Likewise, a number of ocular surface diseases require a continuous improvement in the context of their definition, epidemiology, pathogenesis, diagnosis (particularly, the early detection) and therapy. Currently, there are no universally agreed clinical recommendations on the management of many ocular surface diseases (e.g., dry eye syndrome).

This Special Issue seeks to outline studies targeting the development and application of OCT imaging in diagnosing and interpreting data related to the lacrimal system (e.g., tear film, epithelia, meibomian glands, lacrimal glands, lacrimal dots).

Dr. Pietro Napoli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tear film
  • ocular surface
  • tear film dynamics
  • visual fixation
  • optical coherence tomography
  • ocular disease
  • dry eye
  • meibomian gland
  • lacrimal gland
  • epithelia

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

10 pages, 341 KiB  
Article
Changes in Corneal Epithelial Thickness Induced by Topical Antiglaucoma Medications
by Myungsik Nam and Sun Woong Kim
J. Clin. Med. 2021, 10(16), 3464; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10163464 - 05 Aug 2021
Cited by 10 | Viewed by 1945
Abstract
Corneal thickness measurement is important for assessing intraocular pressure in patients with glaucoma. This study investigated the changes in corneal epithelial thickness (CET) induced by antiglaucoma medications and explored the factors affecting CET measurement. CET was measured over a 9.0 mm diameter area [...] Read more.
Corneal thickness measurement is important for assessing intraocular pressure in patients with glaucoma. This study investigated the changes in corneal epithelial thickness (CET) induced by antiglaucoma medications and explored the factors affecting CET measurement. CET was measured over a 9.0 mm diameter area by using Fourier domain optical coherence tomography in 125 patients with primary open-angle glaucoma and 125 age-matched controls without glaucoma. The influence of sex, age, benzalkonium chloride (BAK)-containing instillations, disease severity, and types and numbers of medications was analyzed using simple and multiple regression analyses. CET over 25 sectors was smaller in the glaucoma group than in the control group (mean difference of 4.2 µm in the central 2.0 mm zone; 52.8 ± 3.6 vs. 48.5 ± 3.9, p < 0.001). Simple regression analysis revealed age, use of β-blockers, prostaglandin, carbonic anhydrase inhibitors, total number of medications, and number of daily BAK-containing instillations were associated with a thinner epithelium. Multiple regression analysis revealed β-blockers, prostaglandin, and number of BAK-containing instillations were significant factors. Use of β-blockers and number of BAK-containing instillations were also associated with a thinner epithelium in the monotherapy subgroup analysis. CET was significantly smaller in patients with glaucoma receiving topical medications and was affected by the use of β-blockers, prostaglandin, and BAK. Full article
(This article belongs to the Special Issue Application and Development of OCT Imaging in the Analysis of the Lacrimal System and Ocular Surface Epithelia)
►▼ Show Figures

Figure 1

11 pages, 931 KiB  
Article
The Association between Tear Film Thickness as Measured with OCT and Symptoms and Signs of Dry Eye Disease: A Pooled Analysis of 6 Clinical Trials
by Gerhard Garhöfer, Valentin Aranha Dos Santos, Hannes Stegmann, Doreen Schmidl, Narine Adzhemian, René M. Werkmeister and Leopold Schmetterer
J. Clin. Med. 2020, 9(11), 3791; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm9113791 - 23 Nov 2020
Cited by 7 | Viewed by 2649
Abstract
Purpose: To determine the association between tear film thickness (TFT) as measured with ultra-high resolution optical coherence tomography (UHR-OCT) and signs and symptoms of dry eye disease (DED). Methods: A total of 450 eyes from 225 patients with DED from six different randomized [...] Read more.
Purpose: To determine the association between tear film thickness (TFT) as measured with ultra-high resolution optical coherence tomography (UHR-OCT) and signs and symptoms of dry eye disease (DED). Methods: A total of 450 eyes from 225 patients with DED from six different randomized clinical trials were included in this pooled analysis. In all subjects, TFT was measured with a custom-built UHR-OCT system. Symptoms of DED were quantified using a standardized Ocular Surface Disease Index (OSD)I questionnaire and clinical signs including tear film break up time (TFBUT) and Schirmer I test were assessed. Associations of the average TFT with OSDI, TFBUT, and Schirmer I test were calculated using a linear regression analysis. Results: The average TFT of the included sample (mean age, 45.0 ± 13.3 years; 65% female) was 4.2 ± 0.5 µm and the OSDI 36.2 ± 10.4. A significant negative correlation was found between TFT and OSDI (r = −0.36 to −0.31; p < 0.001). Tear break up time and Schirmer I test were not correlated with OSDI. Significant albeit weak correlations were found between TFT and TFBUT (r = 0.17 to 0.25; p < 0.01) as well as Schirmer I (r = 0.36 to 0.37; p < 0.001). Subgroup analysis revealed that the correlation was stronger in the subjects with abnormal Schirmer I (<15 mm; r = 0.50 to 0.54; p < 0.001). Conclusions: The present study demonstrates an objective measurement of TFT using a novel OCT approach for DED that correlates with symptoms and signs of DED. Our data are consistent with the idea that TFT represents the aqueous-deficient component of DED. Full article
(This article belongs to the Special Issue Application and Development of OCT Imaging in the Analysis of the Lacrimal System and Ocular Surface Epithelia)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop