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Balance and Gait in Patients with Parkinson's Disease
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Balance and Gait in Patients with Parkinson's Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 2830

Special Issue Editor

Prof. Jinse Park

E-Mail
Guest Editor
Department of Neurology, Haeundae Paik Hospital, Inje University, Busan, Korea
Interests: gait analysis; wearable technology; gait; postural balance; Parkinson’s disease; dementia

Special Issue Information

Dear Colleagues,

Gait disturbance and postural instability have been challenging issues in the management of patients with Parkinson’s disease (PD). Balance and gait are strongly related to quality of life and prognosis in PD; however, exact pathophysiology and treatment is unknown. With technical development, objective measurement and assessing of balance and gait is possible. Accordingly, many researchers have been very interested in this field in recent years. This Special Issue will collect the work of researchers who study balance and gait in PD. The aim of this Special Issue is to provide updated information on advanced technology for diagnosis, pharmacological and non-pharmacological approaches, and the pathophysiology of balance and gait in PD. We also welcome neuroimaging studies investigating the mechanism of balance and gait in PD.

Prof. Jinse Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson’s disease
  • Movement disorder
  • Freezing of gait
  • Balance
  • Gait analysis
  • Wearable sensor
  • Falling
  • Pharmacological treatment
  • Rehabilitation
  • Exercise
  • Quality of life

Published Papers (1 paper)

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Research

11 pages, 1188 KiB  
Article
Association of Postural Instability with Autonomic Dysfunction in Early Parkinson’s Disease
by Sooyeoun You, Hyun Ah Kim and Hyung Lee
J. Clin. Med. 2020, 9(11), 3786; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm9113786 - 23 Nov 2020
Cited by 6 | Viewed by 2384
Abstract
Background: There have been several pathologic data that support an association between postural instability (PI) and autonomic dysfunction in Parkinson’s disease (PD). The purpose of this study was to investigate the correlation of PI and autonomic deficits in early PD. Methods: We collected [...] Read more.
Background: There have been several pathologic data that support an association between postural instability (PI) and autonomic dysfunction in Parkinson’s disease (PD). The purpose of this study was to investigate the correlation of PI and autonomic deficits in early PD. Methods: We collected 17 patients with a diagnosis of early PD. PI was assessed by computerized dynamic posturography (CDP). Standardized autonomic function test (AFT) and time and frequency domain spectral analysis of heart rate variability (HRV) were performed. CDP data obtained from the 21 patients were compared to that from age- and sex-matched healthy controls. We collected HRV data from 18 other age- and sex-matched controls. All patients were evaluated in the “OFF” state. We used Mann–Whitney U-test to compare parameters of CDP between the early PD and control groups. Spearman correlation was used for correlation analysis between parameters of CDP and autonomic function test in PD patients. Results: Most patients (76.5%) showed mild or moderate autonomic dysfunction in the standardized AFT. In CDP, sensory ratios of equilibrium score (e.g., visual and vestibular) and composite scores were significantly lower in PD patients than in controls. In HRV, the low-frequency/high-frequency ratio during the tilt and the gap of low- frequency/high-frequency ratio from supine to tilt were significantly different in both groups. The parameters of time and frequency domains of HRV reflecting parasympathetic function were correlated with equilibrium scores for somatosensory organization test in CDP. Discussion: PI was associated with parasympathetic autonomic dysfunction in early PD. This result was in accordance with a previous assumption that PI in PD is related to parasympathetic cholinergic neuron loss in the brainstem. Full article
(This article belongs to the Special Issue Balance and Gait in Patients with Parkinson's Disease)
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