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Advanced Materials Applied in Drug Delivery
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Advanced Materials Applied in Drug Delivery

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 6458

Special Issue Editor

Dr. Syed Nasir Abbas Bukhari

E-Mail Website
Guest Editor
College of Pharmacy, Jouf University, Sakakah, Saudi Arabia
Interests: drug discovery; drug delivery; anticancer; anti-inflammatory; biomaterials; organic synthesis; chemical characterization; small molecules

Special Issue Information

Dear Colleagues,

Drug delivery technology has aided patient health in a variety of ways, including improved drug distribution, lower off-target accumulation, and increased patient compliance. Advances in delivery mechanisms have greatly aided successful drugs. Significant progress has been made in the design and implementation of safe and functional biomaterials in recent years, and is a concept that has been actively pushed for. Biomaterials are natural, synthetic, or semi-synthetic origin materials developed for implantation in living organisms. Both natural and synthetic materials compete in the field of biomaterials. Natural biomaterials have many advantages over synthetic polymers, which are frequently polysaccharide- or protein-based and derived from plants and animals. These advantages include biocompatibility, biodegradability, widespread availability, and distinctive biological activity. Natural biopolymers have a lengthy history of application in drug/gene delivery systems, as well as in the food and pharmaceutical industries, indicating a bright future in biomedical engineering.

Various biodegradable polymers have been developed to carry drugs, macromolecules, cells, and enzymes. These polymers' biodegradability can be modified by including labile groups such as ester, orthoester, anhydride, carbonate, amide, urea, and urethane into their backbone, which contributes to their broad appeal. Drug delivery polymers have been extensively researched, and the release of macromolecules from polymers has been examined. The theme of this Special Issue is "Advanced Natural and Synthetic Materials Applied in Drug Delivery". Researchers are welcome to submit their original articles and review papers to this Special Issue. The research topics include but are not limited to:

  1. High-value natural products as a source of biomaterials for cancer;
  2. Drug delivery systems in cancer therapy;
  3. Advanced nanotechnology in drug delivery;
  4. Synthesis and characterization of materials used in drug delivery
  5. Design, synthesis, and applications of anticancer drugs

I look forward to receiving your contributions.

Dr. Syed Nasir Abbas Bukhari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer
  • organic synthesis
  • drug delivery
  • nanoparticles
  • nanocarriers
  • natural materials

Published Papers (3 papers)

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Research

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20 pages, 6868 KiB  
Article
High-Precision 3D Printing of Microporous Cochlear Implants for Personalized Local Drug Delivery
by Aikaterini Isaakidou, Iulian Apachitei, Lidy Elena Fratila-Apachitei and Amir Abbas Zadpoor
J. Funct. Biomater. 2023, 14(10), 494; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb14100494 - 03 Oct 2023
Cited by 1 | Viewed by 2330
Abstract
Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood–labyrinth barrier. Local drug delivery systems can ensure [...] Read more.
Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood–labyrinth barrier. Local drug delivery systems can ensure therapeutic drug concentrations locally while preventing adverse effects caused by high dosages of systemically administered drugs. Here, we aimed to design, fabricate, and characterize a local drug delivery system for the human cochlea. The design was relevant to the size of the human ear, included two different shapes, and incorporated two different microporous structures acting as reservoirs for drug loading and release. The four cochlear implant designs were printed using the two-photon polymerization (2PP) technique and the IP-Q photoresist. The optimized 2PP process enabled the fabrication of the cochlear implants with great reproducibility and shape fidelity. Rectangular and cylindrical implants featuring cylindrical and tapered tips, respectively, were successfully printed. Their outer dimensions were 0.6 × 0.6 × 2.4 mm3 (L × W × H). They incorporated internal porous networks that were printed with high accuracy, yielding pore sizes of 17.88 ± 0.95 μm and 58.15 ± 1.62 μm for the designed values of 20 μm and 60 μm, respectively. The average surface roughness was 1.67 ± 0.24 μm, and the water contact angle was 72.3 ± 3.0°. A high degree of polymerization (~90%) of the IP-Q was identified after printing, and the printed material was cytocompatible with murine macrophages. The cochlear implants designed and 3D printed in this study, featuring relevant sizes for the human ear and tunable internal microporosity, represent a novel approach for personalized treatment of hearing loss through local drug delivery. Full article
(This article belongs to the Special Issue Advanced Materials Applied in Drug Delivery)
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20 pages, 4946 KiB  
Article
A Potential Effect of Circadian Rhythm in the Delivery/Therapeutic Performance of Paclitaxel–Dendrimer Nanosystems
by Tânia Albuquerque, Ana Raquel Neves, Milan Paul, Swati Biswas, Elena Vuelta, Ignacio García-Tuñón, Manuel Sánchez-Martin, Telma Quintela and Diana Costa
J. Funct. Biomater. 2023, 14(7), 362; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb14070362 - 11 Jul 2023
Viewed by 1602
Abstract
The circadian clock controls behavior and physiology. Presently, there is clear evidence of a connection between this timing system and cancer development/progression. Moreover, circadian rhythm consideration in the therapeutic action of anticancer drugs can enhance the effectiveness of cancer therapy. Nanosized drug delivery [...] Read more.
The circadian clock controls behavior and physiology. Presently, there is clear evidence of a connection between this timing system and cancer development/progression. Moreover, circadian rhythm consideration in the therapeutic action of anticancer drugs can enhance the effectiveness of cancer therapy. Nanosized drug delivery systems (DDS) have been demonstrated to be suitable engineered platforms for drug targeted/sustained release. The investigation of the chronobiology-nanotechnology relationship, i.e., timing DDS performance according to a patient’s circadian rhythm, may greatly improve cancer clinical outcomes. In the present work, we synthesized nanosystems based on an octa-arginine (R8)-modified poly(amidoamine) dendrimer conjugated with the anticancer drug paclitaxel (PTX), G4-PTX-R8, and its physicochemical properties were revealed to be appropriate for in vitro delivery. The influence of the circadian rhythm on its cellular internalization efficiency and potential therapeutic effect on human cervical cancer cells (HeLa) was studied. Cell-internalized PTX and caspase activity, as a measure of induced apoptosis, were monitored for six time points. Higher levels of PTX and caspase-3/9 were detected at T8, suggesting that the internalization of G4-PTX-R8 into HeLa cells and apoptosis are time-specific/-regulated phenomena. For a deeper understanding, the clock protein Bmal1—the main regulator of rhythmic activity, was silenced by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. Bmal1 silencing was revealed to have an impact on both PTX release and caspase activity, evidencing a potential role for circadian rhythm on drug delivery/therapeutic effect mediated by G4-PTX-R8. Full article
(This article belongs to the Special Issue Advanced Materials Applied in Drug Delivery)
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Review

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15 pages, 1198 KiB  
Review
Bilosomes as Nanocarriers for the Drug and Vaccine Delivery against Gastrointestinal Infections: Opportunities and Challenges
by Elham Zarenezhad, Mahrokh Marzi, Hussein T. Abdulabbas, Saade Abdalkareem Jasim, Seyed Amin Kouhpayeh, Silvia Barbaresi, Shiva Ahmadi and Abdolmajid Ghasemian
J. Funct. Biomater. 2023, 14(9), 453; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb14090453 - 01 Sep 2023
Cited by 4 | Viewed by 2126
Abstract
The gastrointestinal tract (GIT) environment has an intricate and complex nature, limiting drugs’ stability, oral bioavailability, and adsorption. Additionally, due to the drugs’ toxicity and side effects, renders are continuously seeking novel delivery systems. Lipid-based drug delivery vesicles have shown various loading capacities [...] Read more.
The gastrointestinal tract (GIT) environment has an intricate and complex nature, limiting drugs’ stability, oral bioavailability, and adsorption. Additionally, due to the drugs’ toxicity and side effects, renders are continuously seeking novel delivery systems. Lipid-based drug delivery vesicles have shown various loading capacities and high stability levels within the GIT. Indeed, most vesicular platforms fail to efficiently deliver drugs toward this route. Notably, the stability of vesicular constructs is different based on the different ingredients added. A low GIT stability of liposomes and niosomes and a low loading capacity of exosomes in drug delivery have been described in the literature. Bilosomes are nonionic, amphiphilic, flexible surfactant vehicles that contain bile salts for the improvement of drug and vaccine delivery. The bilosomes’ stability and plasticity in the GIT facilitate the efficient carriage of drugs (such as antimicrobial, antiparasitic, and antifungal drugs), vaccines, and bioactive compounds to treat infectious agents. Considering the intricate and harsh nature of the GIT, bilosomal formulations of oral substances have a remarkably enhanced delivery efficiency, overcoming these conditions. This review aimed to evaluate the potential of bilosomes as drug delivery platforms for antimicrobial, antiviral, antifungal, and antiparasitic GIT-associated drugs and vaccines. Full article
(This article belongs to the Special Issue Advanced Materials Applied in Drug Delivery)
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