Host Response to Fungal Pathogens

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1980

Special Issue Editors


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Guest Editor
South Texas Center for Emerging Infectious Diseases, Department of Biology, University of Texas at San Antonio, San Antonio, TX, USA
Interests: fungal immunology; vaccine development host–pathogen interaction; coccidioidomcyosis; fungal virulence factors
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Guest Editor
Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Interests: fungal immunology; host–pathogen interaction; mucosal candidiasis; fungal virulence factors

Special Issue Information

Dear Colleagues,

Fungal pathogens have been and continue to be one of the major causes of chronic and life-threatening diseases, posing significant health, social and economic burdens. Combating the fungal diseases caused by opportunistic and primary pathogens requires a holistic understanding of the mechanisms underlying host–pathogen interplay. Antifungal immunity is quite diverse and highly complex. Even though there have been many advances in our knowledge, gaps in immune mechanisms against mycoses remain. The Special Issue, “Host Response to Fungal Pathogens”, aims to present recent advances in our knowledge on aspects of host and fungal interactions. The areas of interest include humoral and cellular host responses to fungal products and virulence factors, cellular and molecular mechanisms of antifungal immunity, immune dysregulation and immunomodulation, fungal immunopathogenesis, vaccine-induced protective mechanisms against fungal infection, and the discovery of immune biomarkers that can be used to stratify disease management and therapeutic efficacy.

Therefore, this Special Issue in Journal of Fungi invites the submission of original research articles, review papers and short communications. Potential topics include (but are not limited to) the following:

  • Immunity to pathogens and fungal commensals/pathobionts;
  • Innate immune responses;
  • Adaptive immune responses;
  • Fungal interactions with immune cells and non-immune cells (e.g., epithelial cells, endothelial cells, etc.);
  • Vaccine-induced protective immunity;
  • Omics-technology-based studies of host–fungus interactions;
  • Nutrition immunity to fungal infection;
  • Fungal infection models.

Dr. Chiung-Yu Hung
Dr. Brian Peters
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • host-pathogen interaction
  • protective immunity
  • fungal diseases
  • fungal virulence
  • fungal pathogenesis
  • innate immunity to fungal infection
  • adaptive immunity to fungal infection

Published Papers (1 paper)

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Research

15 pages, 3250 KiB  
Article
Aspergillus fumigatus Extracellular Vesicles Display Increased Galleria mellonella Survival but Partial Pro-Inflammatory Response by Macrophages
by Mateus Silveira Freitas, Tamires Aparecida Bitencourt, Caroline Patini Rezende, Nubia Sabrina Martins, Thales de Mileto Henrique Dourado, Carlos R. Tirapelli and Fausto Almeida
J. Fungi 2023, 9(5), 541; https://0-doi-org.brum.beds.ac.uk/10.3390/jof9050541 - 04 May 2023
Cited by 3 | Viewed by 1685
Abstract
Fungal extracellular vesicles (EVs) mediate intra- and interspecies communication and are critical in host–fungus interaction, modulating inflammation and immune responses. In this study, we evaluated the in vitro pro- and anti-inflammatory properties of Aspergillus fumigatus EVs over innate leukocytes. A. fumigatus EVs induced [...] Read more.
Fungal extracellular vesicles (EVs) mediate intra- and interspecies communication and are critical in host–fungus interaction, modulating inflammation and immune responses. In this study, we evaluated the in vitro pro- and anti-inflammatory properties of Aspergillus fumigatus EVs over innate leukocytes. A. fumigatus EVs induced a partial proinflammatory response by macrophages, characterized by increased tumor necrosis factor-alpha production, and increased gene expression of induced nitric oxide synthase and adhesion molecules. EVs induce neither NETosis in human neutrophils nor cytokine secretion by peripheral mononuclear cells. However, prior inoculation of A. fumigatus EVs in Galleria mellonella larvae resulted in increased survival after the fungal challenge. Taken together, these findings show that A. fumigatus EVs play a role in protection against fungal infection, although they induce a partial pro-inflammatory response. Full article
(This article belongs to the Special Issue Host Response to Fungal Pathogens)
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