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Dear Colleagues,

Nuclear DNA is the main target of ionizing radiation (IR) exposure, followed by many types of DNA damages. DNA double-strand breaks (DSBs) induced by IR are considered the most relevant lesion for mutations and carcinogenesis, and unrepaired or misrepaired DSBs are a serious threat to genomic integrity. The different types and extents of DNA damage differ on the radiation types and doses. Higher linear energy transfer (LET) particle radiation, including protons, neutrons, alpha particles (helium ions), and high (H) atomic number (Z) and energy (E) (HZE) ions, is known to induce substantially more complex spectrum DNA damages induction and slower DNA repair kinetics. The cellular responses to high-LET radiation are still not fully understood. High-LET radiation is a useful tool in cancer therapy, but there are health risks to space radiation in future space travel.

This Special Issue aims to highlight recent advances in all aspects of DNA damage induced by high-LET ionizing radiations and cellular responses to these damages, including analytical methods, chemical biology, computational modelling, as well as proteomics. Submissions of original research articles, short communications, perspectives, and comprehensive review articles are all welcome (submission deadline 30 October 2022).

In order to plan this Special Issue, I would appreciate hearing from you if you are willing to contribute to this project. I hope this invitation will receive your favourable consideration.

Dr. Megumi Hada
Prof. Dr. Alexandros Georgakilas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

high LET radiation
clustered DNA damage
DNA damage response

Published Papers (2 papers)

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Research

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0 pages, 1572 KiB

Open AccessArticle

Repair Kinetics of DSB-Foci Induced by Proton and α-Particle Microbeams of Different Energies

by Ana Belchior, João F. Canhoto, Ulrich Giesen, Frank Langner, Hans Rabus and Reinhard Schulte

Life 2022, 12(12), 2040; https://0-doi-org.brum.beds.ac.uk/10.3390/life12122040 - 06 Dec 2022

Cited by 1 | Viewed by 1353 | Correction

Abstract

In this work, the induction and repair of radiation-induced 53BP1 foci were studied in human umbilical vein endothelial cells irradiated at the PTB microbeam with protons and α-particles of different energies. The data were analyzed in terms of the mean number of 53BP1 foci induced by the different ion beams. The number of 53BP1 foci found at different times post-irradiation suggests that the disappearance of foci follows first order kinetics. The mean number of initially produced foci shows the expected increase with LET. The most interesting finding of this work is that the absolute number of persistent foci increases with LET but not their fraction. Furthermore, protons seem to produce more persistent foci as compared to α-particles of even higher LET. This may be seen as experimental evidence that protons may be more effective in producing severe DNA lesions, as was already shown in other work, and that LET may not be the best suited parameter to characterize radiation quality. Full article

(This article belongs to the Special Issue Ionizing Radiation of High LET and DNA Damage Responses)

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