Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.6
5.4
Journals
Marine Drugs
Special Issues
Regenerative Potential of Marine Natural Compounds
share announcement

Regenerative Potential of Marine Natural Compounds

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 15222

Special Issue Editors

Prof. Dr. Marco Patruno

E-Mail Website
Chief Guest Editor
Department of Comparative Biomedicine and Food Science BCA, University of Padova, Italy
Interests: stem cells; cell biology; immunohistochemistry muscle; regenerative medicine; tissue engineering
Dr. Michela Sugni

E-Mail Website
Co-Guest Editor
Department of Environmental Science and Policy, University of Milan, Via Celoria, 2, 20133 Milan, Italy
Interests: marine collagen; biomaterials; echinoderms; regeneration; circular economy
Special Issues, Collections and Topics in MDPI journals
Dr. Luca Melotti

E-Mail Website
Co-Guest Editor
Department of Comparative Biomedicine and Food Science BCA, University of Padova, Italy
Interests: regenerative medicine; adult stem cells; skin tissue engineering; skin wound healing

Special Issue Information

Dear colleagues，

Tissue engineering and regenerative medicine applications are two different approaches aiming to replace or regenerate damaged tissues by combining cells, materials, and molecules. The use of biomaterials or compounds of marine origin for regenerative purposes has been explored during the last few years. Notable examples are the use of marine natural products as scaffolds, such as coral bioceramics or chitosan, or marine peptides as signaling factors like collagen peptides. However, their application in combination with stem cells or cellular components has not been widely tested yet. Marine ecosystems are a huge source of undiscovered marine natural compounds that could provide unique opportunities for different biomedical applications, tissue engineering and regenerative medicine included. Moreover, these natural compounds are often obtained as by-products from different human activities, making them ecological and in the perspective of a circular economy.

This Special Issue of the international scientific journal Marine Drugs will give an overview of recent findings on the application of marine natural products of different natures in the tissue regeneration context.

Prof. Dr. Marco Patruno
Chief Guest Editor
Prof. Dr. Michela Sugni
Dr. Luca Melotti
co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • regenerative medicine
  • stem cells
  • marine natural products

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 8445 KiB  
Article
Changes in the Molecular Characteristics of Bovine and Marine Collagen in the Presence of Proteolytic Enzymes as a Stage Used in Scaffold Formation
by Marfa N. Egorikhina, Ludmila L. Semenycheva, Victoria O. Chasova, Irina I. Bronnikova, Yulia P. Rubtsova, Evgeniy A. Zakharychev and Diana Ya. Aleynik
Mar. Drugs 2021, 19(9), 502; https://0-doi-org.brum.beds.ac.uk/10.3390/md19090502 - 02 Sep 2021
Cited by 6 | Viewed by 4236
Abstract
Biopolymers, in particular collagen and fibrinogen, are the leading materials for use in tissue engineering. When developing technology for scaffold formation, it is important to understand the properties of the source materials as well as the mechanisms that determine the formation of the [...] Read more.
Biopolymers, in particular collagen and fibrinogen, are the leading materials for use in tissue engineering. When developing technology for scaffold formation, it is important to understand the properties of the source materials as well as the mechanisms that determine the formation of the scaffold structures. Both factors influence the properties of scaffolds to a great extent. Our present work aimed to identify the features of the molecular characteristics of collagens of different species origin and the changes they undergo during the enzymatic hydrolysis used for the process of scaffold formation. For this study, we used the methods of gel-penetrating chromatography, dynamic light scattering, reading IR spectra, and scanning electron microscopy. It was found that cod collagen (CC) and bovine collagen (BC) have different initial molecular weight parameters, and that, during hydrolysis, the majority of either type of protein is hydrolyzed by the proteolytic enzymes within the first minute. The differently sourced collagen samples were also hydrolyzed with the formation of two low molecular fractions: Mw ~ 10 kDa and ~20 kDa. In the case of CC, the microstructure of the final scaffolds contained denser, closely spaced fibrillar areas, while the BC-sourced scaffolds had narrow, short fibrils composed of unbound fibers of hydrolyzed collagen in their structure. Full article
(This article belongs to the Special Issue Regenerative Potential of Marine Natural Compounds)
►▼ Show Figures

Graphical abstract

19 pages, 3169 KiB  
Article
Jellyfish Collagen: A Biocompatible Collagen Source for 3D Scaffold Fabrication and Enhanced Chondrogenicity
by Zara Ahmed, Lydia C. Powell, Navid Matin, Andrew Mearns-Spragg, Catherine A. Thornton, Ilyas M. Khan and Lewis W. Francis
Mar. Drugs 2021, 19(8), 405; https://0-doi-org.brum.beds.ac.uk/10.3390/md19080405 - 22 Jul 2021
Cited by 16 | Viewed by 3893
Abstract
Osteoarthritis (OA) is a multifactorial disease leading to degeneration of articular cartilage, causing morbidity in approximately 8.5 million of the UK population. As the dense extracellular matrix of articular cartilage is primarily composed of collagen, cartilage repair strategies have exploited the biocompatibility and [...] Read more.
Osteoarthritis (OA) is a multifactorial disease leading to degeneration of articular cartilage, causing morbidity in approximately 8.5 million of the UK population. As the dense extracellular matrix of articular cartilage is primarily composed of collagen, cartilage repair strategies have exploited the biocompatibility and mechanical strength of bovine and porcine collagen to produce robust scaffolds for procedures such as matrix-induced chondrocyte implantation (MACI). However, mammalian sourced collagens pose safety risks such as bovine spongiform encephalopathy, transmissible spongiform encephalopathy and possible transmission of viral vectors. This study characterised a non-mammalian jellyfish (Rhizostoma pulmo) collagen as an alternative, safer source in scaffold production for clinical use. Jellyfish collagen demonstrated comparable scaffold structural properties and stability when compared to mammalian collagen. Jellyfish collagen also displayed comparable immunogenic responses (platelet and leukocyte activation/cell death) and cytokine release profile in comparison to mammalian collagen in vitro. Further histological analysis of jellyfish collagen revealed bovine chondroprogenitor cell invasion and proliferation in the scaffold structures, where the scaffold supported enhanced chondrogenesis in the presence of TGFβ1. This study highlights the potential of jellyfish collagen as a safe and biocompatible biomaterial for both OA repair and further regenerative medicine applications. Full article
(This article belongs to the Special Issue Regenerative Potential of Marine Natural Compounds)
►▼ Show Figures

Graphical abstract

18 pages, 6578 KiB  
Article
From Food Waste to Innovative Biomaterial: Sea Urchin-Derived Collagen for Applications in Skin Regenerative Medicine
by Cinzia Ferrario, Francesco Rusconi, Albana Pulaj, Raffaella Macchi, Paolo Landini, Moira Paroni, Graziano Colombo, Tiziana Martinello, Luca Melotti, Chiara Gomiero, M. Daniela Candia Carnevali, Francesco Bonasoro, Marco Patruno and Michela Sugni
Mar. Drugs 2020, 18(8), 414; https://0-doi-org.brum.beds.ac.uk/10.3390/md18080414 - 06 Aug 2020
Cited by 45 | Viewed by 6302
Abstract
Collagen-based skin-like scaffolds (CBSS) are promising alternatives to skin grafts to repair wounds and injuries. In this work, we propose that the common marine invertebrate sea urchin represents a promising and eco-friendly source of native collagen to develop innovative CBSS for skin injury [...] Read more.
Collagen-based skin-like scaffolds (CBSS) are promising alternatives to skin grafts to repair wounds and injuries. In this work, we propose that the common marine invertebrate sea urchin represents a promising and eco-friendly source of native collagen to develop innovative CBSS for skin injury treatment. Sea urchin food waste after gonad removal was here used to extract fibrillar glycosaminoglycan (GAG)-rich collagen to produce bilayer (2D + 3D) CBSS. Microstructure, mechanical stability, permeability to water and proteins, ability to exclude bacteria and act as scaffolding for fibroblasts were evaluated. Our data show that the thin and dense 2D collagen membrane strongly reduces water evaporation (less than 5% of water passes through the membrane after 7 days) and protein diffusion (less than 2% of BSA passes after 7 days), and acts as a barrier against bacterial infiltration (more than 99% of the different tested bacterial species is retained by the 2D collagen membrane up to 48 h), thus functionally mimicking the epidermal layer. The thick sponge-like 3D collagen scaffold, structurally and functionally resembling the dermal layer, is mechanically stable in wet conditions, biocompatible in vitro (seeded fibroblasts are viable and proliferate), and efficiently acts as a scaffold for fibroblast infiltration. Thus, thanks to their chemical and biological properties, CBSS derived from sea urchins might represent a promising, eco-friendly, and economically sustainable biomaterial for tissue regenerative medicine. Full article
(This article belongs to the Special Issue Regenerative Potential of Marine Natural Compounds)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop