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Advances in Biohybrid Micro/Nanostructures
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Advances in Biohybrid Micro/Nanostructures

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 3394

Special Issue Editors

Dr. Soubantika Palchoudhury

E-Mail Website
Guest Editor
Chemical and Materials Engineering, University of Dayton, 300 College Park Ave, Dayton, OH 45469, USA
Interests: biohybrid nanoarchitectures; bio-inspired energy; drug delivery; material characterization; environmental nanoengineering
Special Issues, Collections and Topics in MDPI journals
Dr. Nirupam Aich

E-Mail Website
Guest Editor
Department of Civil, Structural and Environmental Engineering, University at Buffalo, 232 Jarvis Hall, Buffalo, NY 14260, USA
Interests: nanohybrids; water treatment; sustainable nanotechnology; safer design
Special Issues, Collections and Topics in MDPI journals
Dr. Ziyou Zhou

E-Mail Website
Guest Editor
Luna Innovations Inc., Roanoke, VA, USA
Interests: biomimic nanoarchitectures, nanopharmaceutics; antiviral nanoparticles; drug delivery; vaccine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biohybrid nanostructures make up a remarkable class of materials, as they combine the structural flexibility and multifunctional ligand platform of biological systems with the attributes of inorganic nanocrystals. The synthesis of these nanostructures involves a complex intersection of chemistry, surface modification, and biology, as it is challenging to incorporate aqueous-phase biological units with inorganic nanocrystals that prefer nonpolar solvents. The biohybrid nanostructures possess unique crystal phases and material properties. Understanding their structure–property relationships is key to driving new innovations in biomedical materials. Therefore, various emerging material characterization techniques have been used to gain insights on the formation mechanism, properties, and fundamental physics which drive these novel nanoarchitectures. The unique material properties of biohybrid nanostructures can serve to catalyze new advances in biomedical applications, including biopharmaceuticals, drug delivery platforms, and diagnostic agents. This Special Issue will focus on capturing emerging trends in the synthesis, characterization, and application of biohybrid nanostructures. We hope to attract original research articles, reviews, and perspectives which describe the current state-of-the-art, challenges, and future frontiers in biohybrid nanostructures.

Dr. Soubantika Palchoudhury
Dr. Nirupam Aich
Dr. Ziyou Zhou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biohybrid nanoparticles
  • biomimetics
  • nanochemistry
  • material characterization
  • drug delivery
  • diagnostics
  • bioengineering

Published Papers (2 papers)

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Research

18 pages, 6350 KiB  
Article
A Novel Experimental Approach to Understand the Transport of Nanodrugs
by Soubantika Palchoudhury, Parnab Das, Amirehsan Ghasemi, Syed Mohammed Tareq, Sohini Sengupta, Jinchen Han, Sarah Maglosky, Fajer Almanea, Madison Jones, Collin Cox and Venkateswar Rao
Materials 2023, 16(15), 5485; https://0-doi-org.brum.beds.ac.uk/10.3390/ma16155485 - 5 Aug 2023
Cited by 1 | Viewed by 1523
Abstract
Nanoparticle-based drugs offer attractive advantages like targeted delivery to the diseased site and size and shape-controlled properties. Therefore, understanding the particulate flow of the nanodrugs is important for effective delivery, accurate prediction of required dosage, and developing efficient drug delivery platforms for nanodrugs. [...] Read more.
Nanoparticle-based drugs offer attractive advantages like targeted delivery to the diseased site and size and shape-controlled properties. Therefore, understanding the particulate flow of the nanodrugs is important for effective delivery, accurate prediction of required dosage, and developing efficient drug delivery platforms for nanodrugs. In this study, the transport of nanodrugs including flow velocity and deposition is investigated using three model metal oxide nanodrugs of different sizes including iron oxide, zinc oxide, and combined Cu-Zn-Fe oxide synthesized via a modified polyol approach. The hydrodynamic size, size, morphology, chemical composition, crystal phase, and surface functional groups of the water-soluble nanodrugs were characterized via dynamic light scattering, transmission electron microscopy, scanning electron microscopy-energy dispersive X-ray, X-ray diffraction, and fourier transform infrared spectroscopy, respectively. Two different biomimetic flow channels with customized surfaces are developed via 3D printing to experimentally monitor the velocity and deposition of the different nanodrugs. A diffusion dominated mechanism of flow is seen in size ranges 92 nm to 110 nm of the nanodrugs, from the experimental velocity and mass loss profiles. The flow velocity analysis also shows that the transport of nanodrugs is controlled by sedimentation processes in the larger size ranges of 110–302 nm. However, the combined overview from experimental mass loss and velocity trends indicates presence of both diffusive and sedimentation forces in the 110–302 nm size ranges. It is also discovered that the nanodrugs with higher positive surface charges are transported faster through the two test channels, which also leads to lower deposition of these nanodrugs on the walls of the flow channels. The results from this study will be valuable in realizing reliable and cost-effective in vitro experimental approaches that can support in vivo methods to predict the flow of new nanodrugs. Full article
(This article belongs to the Special Issue Advances in Biohybrid Micro/Nanostructures)
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15 pages, 3640 KiB  
Article
The Effect of PEGylated Graphene Oxide Nanoparticles on the Th17-Polarization of Activated T Helpers
by Svetlana Zamorina, Valeria Timganova, Maria Bochkova, Kseniya Shardina, Sofya Uzhviyuk, Pavel Khramtsov, Darya Usanina and Mikhail Rayev
Materials 2023, 16(2), 877; https://0-doi-org.brum.beds.ac.uk/10.3390/ma16020877 - 16 Jan 2023
Cited by 3 | Viewed by 1544
Abstract
We investigated the direct effect of PEGylated graphene oxide (P-GO) nanoparticles on the differentiation, viability, and cytokine profile of activated T helper type 17 (Th17) in vitro. The subject of the study were cultures of “naive” T-helpers (CD4+) isolated by immunomagnetic separation and [...] Read more.
We investigated the direct effect of PEGylated graphene oxide (P-GO) nanoparticles on the differentiation, viability, and cytokine profile of activated T helper type 17 (Th17) in vitro. The subject of the study were cultures of “naive” T-helpers (CD4+) isolated by immunomagnetic separation and polarized into the Th17 phenotype with a TCR activator and cytokines. It was found that P-GO at low concentrations (5 µg/mL) had no effect on the parameters studied. The presence of high concentrations of P-GO in T-helper cultures (25 μg/mL) did not affect the number and viability of these cells. However, the percentage of proliferating T-helpers in these cultures was reduced. GO nanoparticles modified with linear polyethylene glycol (PEG) significantly increased the percentage of Th17/22 cells in cultures of Th17-polarized T helpers and the production of IFN-γ, whereas those modified with branched PEG suppressed the synthesis of IL-17. Thus, a low concentration of PEGylated GO nanoparticles (5 μg/mL), in contrast to a concentration of 25 μg/mL, has no effect on the Th17-polarization of T helpers, allowing their further use for in-depth studies of the functions of T lymphocytes and other immune cells. Overall, we have studied for the first time the direct effect of P-GO nanoparticles on the conversion of T helper cells to the Th17 phenotype. Full article
(This article belongs to the Special Issue Advances in Biohybrid Micro/Nanostructures)
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