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Advanced Polymer Composite Materials for Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 3898

Special Issue Editor


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Guest Editor
Department of Experimental Biology, The Faculty of Biology and Animal Science, University of Environmental and Life Sciences, Norwida St. 27B, 50-375 Wroclaw, Poland
Interests: osteosarcoma; histiocytosis; osteoblatsts and osteoclasts coupling; bone homeostasis; cell biology; non-coding RNA; targeted cancer therapy; non-invasive biomarkers
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Special Issue Information

Dear Colleagues,

Currently, biomedicine is faced with an urgent need to establish new methods of treatment that improve the regenerative potential of an organism. This is highly connected with the aging of modern societies, followed by the growing prevalence of diseases of civilization such as osteoporosis. There is a great need to develop new therapeutic strategies promote the healing of damaged tissue, while also having a bridging function and enhancing the functional recovery of an organ. The development in the field of biomaterials engineering is outstanding—driven not only by target application in terms of regenerative medicine, but also advances in materials preparation and characterization techniques. Polymer-based composite materials draw attention in various biomedical applications including orthopedics, dentistry, and cardiology. They have proven to be ideal drug delivery systems and platforms promoting the adhesion, proliferation, and differentiation of progenitor cells. These features significantly increase the potential application of composites in the biomedical field. Further, polymer-based composites offer the possibility of tailoring specific properties of devices in order to obtain advantageous mechanical and physiological responses.

The present Special Issue on “Advanced Polymer Composite Materials for Biomedical Applications” will encompass research from various fields, including biomaterials engineering as well as tissue engineering, biology, and chemistry. This Special Issue is dedicated to research related to the design and synthesis of multifunctional polymer composite materials, but also to their physicochemical and biological characterization. Full articles, short communications, and review articles on this topic are welcome.

Dr. Agnieszka Śmieszek
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer-based composites
  • biomedical applications
  • biodegradable polymers
  • tissue engineering
  • cytocompatibility
  • biocompatibility
  • progenitor cells
  • regenerative medicine.

Published Papers (1 paper)

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Research

20 pages, 9245 KiB  
Article
The Potential Selective Cytotoxicity of Poly (L- Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells
by Mateusz Sikora, Klaudia Marcinkowska, Krzysztof Marycz, Rafał Jakub Wiglusz and Agnieszka Śmieszek
Materials 2019, 12(22), 3779; https://0-doi-org.brum.beds.ac.uk/10.3390/ma12223779 - 18 Nov 2019
Cited by 13 | Viewed by 3087
Abstract
Osteosarcoma (OSA) is malignant bone tumor, occurring in children and adults, characterized by poor prognosis. Despite advances in chemotherapy and surgical techniques, the survival of osteosarcoma patients is not improving significantly. Currently, great efforts are taken to identify novel selective strategies, distinguishing between [...] Read more.
Osteosarcoma (OSA) is malignant bone tumor, occurring in children and adults, characterized by poor prognosis. Despite advances in chemotherapy and surgical techniques, the survival of osteosarcoma patients is not improving significantly. Currently, great efforts are taken to identify novel selective strategies, distinguishing between cancer and normal cells. This includes development of biomimetic scaffolds with anticancer properties that can simultaneously support and modulate proper regeneration of bone tissue. In this study cytotoxicity of scaffolds composed from poly (L-lactic acid) functionalized with nanohydroxyapatite (nHAp) and doped with europium (III) ions—10 wt % 3 mol % Eu3+: nHAp@PLLA was tested using human osteosarcoma cells: U-2 OS, Saos-2 and MG-63. Human adipose tissue-derived stromal cells (HuASCs) were used as non-transformed cells to determine the selective cytotoxicity of the carrier. Analysis included evaluation of cells morphology (confocal/scanning electron microscopy (SEM)), metabolic activity and apoptosis profile in cultures on the scaffolds. Results obtained indicated on high cytotoxicity of scaffolds toward all OSA cell lines, associated with a decrease of cells’ viability, deterioration of metabolic activity and activation of apoptotic factors determined at mRNA and miRNA levels. Simultaneously, the biomaterials did not affect HuASCs’ viability and proliferation rate. Obtained scaffolds showed a bioimaging function, due to functionalization with luminescent europium ions, and thus may find application in theranostics treatment of OSA. Full article
(This article belongs to the Special Issue Advanced Polymer Composite Materials for Biomedical Applications)
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