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Advances in Bioactive Materials
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Advances in Bioactive Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 21716

Special Issue Editor

Dr. Ana Alcudia

E-Mail Website
Guest Editor
Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, C/Profesor García González, 2, 41012 Seville, Spain
Interests: coating materials; materials for prosthesis; polymers or gels for biomedicine; synthesis of potentially bioactive entities; modeling and drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The interdisciplinary field of materials science, which focuses on medical applications, is undergoing a radical change over the last decade caused by the search for quality improvement and aiming to increase life expectancy. The structures that conform to bioactive or therapeutic materials have the function of exerting cells, tissues, or organs in living species to produce an adequate biological response, via a cellular or tissue stimuli, or by controlling interactions with microbiological species.

However, there are numerous aspects in which it is necessary to come up with new enhanced materials to provide improved properties that could overcome new challenges coming from medical demands that would need implementation in future manufacturing processes. It is also essential to establish relationships between structure, activity, physical and chemical properties to predict or anticipate behaviors in order to produce significant advances in the design of suitable materials or molecular entities. Among the most significant aspects that still remain unknown and need further more thorough studies toward the achievement of prominent progress are the manufacture of prosthetic coating materials, the use of polymers or gels as therapeutic agents, the development of new synthesis of molecules of interest, the discovery of natural products with new unknown effects; in addition to new materials or nanomaterials that can be used for the controlled release of drugs, diagnosis.

Therefore, this Special Issue is dedicated to research and review papers tackling the problems of using new bioactive or therapeutic materials for medical, biomedical, or engineering applications.

Possible topics for this Special Issue include but are not limited to the following:

  • Bioactive nanomaterials or materials to accelerate diagnostics, vaccines or therapeutics for novel virus.
  • Coatings and materials for prosthesis and studies on their therapeutic effects.
  • Methods in organic synthesis towards new entities as potential drugs.
  • New bioactive natural products applications in medicine as nutraceuticals.
  • Polymers or gels for smart drug delivery.
  • Nanomaterials or materials with antibacterial properties and the insights of its possible mechanisms.
  • Modeling studies to determine the influence between structure and chemical-physical properties of potential bioactive materials.
  • Biodegradable materials, applications and studies of the whole processes.

Dr. Ana Alcudia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coating materials
  • polymers or gels for biomedicine
  • synthesis of potentially bioactive entities
  • modeling and drug delivery of bioactive materials

Published Papers (6 papers)

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Research

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11 pages, 6251 KiB  
Article
An Investigation on Spray-Granulated, Macroporous, Bioactive Glass Microspheres for a Controlled Drug Delivery System
by Henni Setia Ningsih, Liu-Gu Chen, Ren-Jei Chung and Yu-Jen Chou
Materials 2021, 14(11), 3112; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14113112 - 06 Jun 2021
Cited by 4 | Viewed by 2483
Abstract
Bioactive glass (BG) has been regarded as an excellent candidate for biomedical applications due to its superior properties of bioactivity, biocompatibility, osteoconductivity and biodegradability. Thus, in this study, we aimed to fabricate drug carriers that were capable of loading therapeutic antibiotics while promoting [...] Read more.
Bioactive glass (BG) has been regarded as an excellent candidate for biomedical applications due to its superior properties of bioactivity, biocompatibility, osteoconductivity and biodegradability. Thus, in this study, we aimed to fabricate drug carriers that were capable of loading therapeutic antibiotics while promoting bone regeneration using macroporous BG microspheres, prepared by a spray drying method. Characterizations of particle morphology and specific surface area were carried out via scanning electron microscopy and nitrogen adsorption/desorption isotherm. Evaluations of in vitro bioactivity were performed based on Kokubo’s simulated body fluid to confirm the formation of the hydroxyapatite (HA) layer after immersion. In addition, the in vitro drug release behaviors were examined, using tetracycline as the therapeutic antibiotic in pH 7.4 and 5.0 environments. Finally, the results showed that BG microspheres of up to 33 μm could be mass-produced, targeting various therapeutic situations and their resulting bioactivities and drug release behaviors, and related properties were discussed. Full article
(This article belongs to the Special Issue Advances in Bioactive Materials)
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19 pages, 5815 KiB  
Article
Assessment of SnFe2O4 Nanoparticles for Potential Application in Theranostics: Synthesis, Characterization, In Vitro, and In Vivo Toxicity
by Saman Sargazi, Mohammad Reza Hajinezhad, Abbas Rahdar, Muhammad Nadeem Zafar, Aneesa Awan and Francesco Baino
Materials 2021, 14(4), 825; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14040825 - 09 Feb 2021
Cited by 22 | Viewed by 2811
Abstract
In this research, tin ferrite (SnFe2O4) NPs were synthesized via hydrothermal route using ferric chloride and tin chloride as precursors and were then characterized in terms of morphology and structure using Fourier-transform infrared spectroscopy (FTIR), Ultraviolet–visible spectroscopy (UV-Vis), X-ray [...] Read more.
In this research, tin ferrite (SnFe2O4) NPs were synthesized via hydrothermal route using ferric chloride and tin chloride as precursors and were then characterized in terms of morphology and structure using Fourier-transform infrared spectroscopy (FTIR), Ultraviolet–visible spectroscopy (UV-Vis), X-ray power diffraction (XRD), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) method. The obtained UV-Vis spectra was used to measure band gap energy of as-prepared SnFe2O4 NPs. XRD confirmed the spinel structure of NPs, while SEM and TEM analyses disclosed the size of NPs in the range of 15–50 nm and revealed the spherical shape of NPs. Moreover, energy dispersive X-ray spectroscopy (EDS) and BET analysis was carried out to estimate elemental composition and specific surface area, respectively. In vitro cytotoxicity of the synthesized NPs were studied on normal (HUVEC, HEK293) and cancerous (A549) human cell lines. HUVEC cells were resistant to SnFe2O4 NPs; while a significant decrease in the viability of HEK293 cells was observed when treated with higher concentrations of SnFe2O4 NPs. Furthermore, SnFe2O4 NPs induced dramatic cytotoxicity against A549 cells. For in vivo study, rats received SnFe2O4 NPs at dosages of 0, 0.1, 1, and 10 mg/kg. The 10 mg/kg dose increased serum blood urea nitrogen and creatinine compared to the controls (P < 0.05). The pathology showed necrosis in the liver, heart, and lungs, and the greatest damages were related to the kidneys. Overall, the in vivo and in vitro experiments showed that SnFe2O4 NPs at high doses had toxic effects on lung, liver and kidney cells without inducing toxicity to HUVECs. Further studies are warranted to fully elucidate the side effects of SnFe2O4 NPs for their application in theranostics. Full article
(This article belongs to the Special Issue Advances in Bioactive Materials)
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16 pages, 4050 KiB  
Article
Encased Gold Nanoparticle Synthesis as a Probe for Oleuropein Self-Assembled Structure Formation
by Aila Jimenez-Ruiz, Rafael Prado-Gotor, José G. Fernández-Bolaños, Alejandro González-Benjumea and José María Carnerero
Materials 2021, 14(1), 50; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14010050 - 24 Dec 2020
Viewed by 1544
Abstract
Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) concentration in the reaction medium was found to greatly influence the outcome and stability of the resulting nanocolloid, with a marked decrease in particle size being found for [...] Read more.
Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) concentration in the reaction medium was found to greatly influence the outcome and stability of the resulting nanocolloid, with a marked decrease in particle size being found for the more concentrated oleuropein solutions. The protection mechanisms involved in the stabilized nanosystems were analyzed. Oleuropein self-assembled structures were found to be formed at a concentration threshold of [OLE] > 5 × 10−5 M, and observed through the use of CryoSEM imaging. Those structures were responsible for both the increased stability and the decrease in size observed at the more concentrated solutions. Full article
(This article belongs to the Special Issue Advances in Bioactive Materials)
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Review

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27 pages, 1004 KiB  
Review
The Antibacterial Effects of Resin-Based Dental Sealants: A Systematic Review of In Vitro Studies
by Saad Saeed AlShahrani, Mana’a Saleh AlAbbas, Isadora Martini Garcia, Maha Ibrahim AlGhannam, Muath Abdulrahman AlRuwaili, Fabrício Mezzomo Collares and Maria Salem Ibrahim
Materials 2021, 14(2), 413; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14020413 - 15 Jan 2021
Cited by 14 | Viewed by 3359
Abstract
This review aimed to assess the antimicrobial effects of different antibacterial agents/compounds incorporated in resin-based dental sealants. Four databases (PubMed, MEDLINE, Web of Science and Scopus) were searched. From the 8052 records retrieved, 275 records were considered eligible for full-text screening. Nineteen studies [...] Read more.
This review aimed to assess the antimicrobial effects of different antibacterial agents/compounds incorporated in resin-based dental sealants. Four databases (PubMed, MEDLINE, Web of Science and Scopus) were searched. From the 8052 records retrieved, 275 records were considered eligible for full-text screening. Nineteen studies met the inclusion criteria. Data extraction and quality assessment was performed by two independent reviewers. Six of the nineteen included studies were judged to have low risk of bias, and the rest had medium risk of bias. Compounds and particles such as zinc, tin, Selenium, chitosan, chlorhexidine, fluoride and methyl methacrylate were found to be effective in reducing the colony-forming unit counts, producing inhibition zones, reducing the optical density, reducing the metabolic activities, reducing the lactic acid and polysaccharide production and neutralizing the pH when they are added to the resin-based dental sealants. In addition, some studies showed that the antibacterial effect was not significantly different after 2 weeks, 2 months and 6 months aging in distilled water or phosphate-buffered saline. In conclusion, studies have confirmed the effectiveness of adding antibacterial agents/compounds to dental sealants. However, we should consider that these results are based on laboratory studies with a high degree of heterogeneity. Full article
(This article belongs to the Special Issue Advances in Bioactive Materials)
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26 pages, 19070 KiB  
Review
Environmental Impact of Nanoparticles’ Application as an Emerging Technology: A Review
by Guillermo Martínez, Manuel Merinero, María Pérez-Aranda, Eva María Pérez-Soriano, Tamara Ortiz, Eduardo Villamor, Belén Begines and Ana Alcudia
Materials 2021, 14(1), 166; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14010166 - 31 Dec 2020
Cited by 87 | Viewed by 8614
Abstract
The unique properties that nanoparticles exhibit, due to their small size, are the principal reason for their numerous applications, but at the same time, this might be a massive menace to the environment. The number of studies that assess the possible ecotoxicity of [...] Read more.
The unique properties that nanoparticles exhibit, due to their small size, are the principal reason for their numerous applications, but at the same time, this might be a massive menace to the environment. The number of studies that assess the possible ecotoxicity of nanomaterials has been increasing over the last decade to determine if, despite the positive aspects, they should be considered a potential health risk. To evaluate their potential toxicity, models are used in all types of organisms, from unicellular bacteria to complex animal species. In order to better understand the environmental consequences of nanotechnology, this literature review aims to describe and classify nanoparticles, evaluating their life cycle, their environmental releasing capacity and the type of impact, particularly on living beings, highlighting the need to develop more severe and detailed legislation. Due to their diversity, nanoparticles will be discussed in generic terms focusing on the impact of a great variety of them, highlighting the most interesting ones for the industry. Full article
(This article belongs to the Special Issue Advances in Bioactive Materials)
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Other

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2 pages, 184 KiB  
Erratum
Erratum: Guillermo M., et al. Environmental Impact of Nanoparticles’ Application as an Emerging Technology: A Review. Materials 2021, 14, 166
by Guillermo Martínez, Manuel Merinero, María Pérez-Aranda, Eva María Pérez-Soriano, Tamara Ortiz, Eduardo Villamor, Belén Begines and Ana Alcudia
Materials 2021, 14(7), 1710; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14071710 - 31 Mar 2021
Cited by 12 | Viewed by 1408
Abstract
The authors wish to make the following corrections to this paper [...] Full article
(This article belongs to the Special Issue Advances in Bioactive Materials)
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