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Advances in Bone Substitute Biology, Production, and Materials
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Advances in Bone Substitute Biology, Production, and Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 15773

Special Issue Editor

Prof. Dr. Franz E. Weber

E-Mail Website
Guest Editor
Center of Dental Medicine, Oral Biotechnology & Bioengineering/MKG, University of Zurich, Plattenstrasse 11, CH-8032 Zurich, Switzerland
Interests: microarchitecture of scaffolds; osteoconduction; osteoinduction; ceramics; titanium; hydrogels; bone substitute materials; additive manufacturing; GTR/GBR membranes; delivery of epigenetically active small chemicals; delivery of BMPs and other factors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past decade, we have witnessed new developments in bone substitute materials and their production by additive manufacturing. These developments aim towards a better application of osteoinduction, osteoconduction, and stem cells for bone tissue engineering. However, autologous bone grafts are still the gold standard for daily clinical treatments. The main focus of the forthcoming ‘Advances in Bone Substitute Biology, Production, and Materials’ issue is to present a comprehensive overview of these new developments. Recent advances  our understanding of bone substitute biology and enabling production technologies of bone substitutes, including personalized approaches will be addressed. The various topics encompass all kinds of new materials their interaction with biological systems and production methodologies like additive manufacturing/3D-printing, osteoconduction, surface modifications, osteoinduction, and the application of stem cells. Moreover, I would like to include sophisticated examples of successful combinations already tested for their application in dentistry and orthopedics.

With immense pleasure, I invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are welcome.

Prof. Dr. Franz E. Weber
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bone substitute materials
  • Biology of bone/material interference
  • Osteoconduction
  • Osteoinduction
  • Stem cells for bone regeneration
  • Additive manufacturing/bio printing
  • Delivery of stem cells, small chemicals and factors
  • Guided bone regeneration
  • Epigenetics and bone tissue engineering
  • In vivo and in vitro test systems for bone tissue engineering

Published Papers (3 papers)

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Research

10 pages, 3042 KiB  
Article
The Release of the Bromodomain Ligand N,N-Dimethylacetamide Adds Bioactivity to a Resorbable Guided Bone Regeneration Membrane in a Rabbit Calvarial Defect Model
by Barbara Siegenthaler, Chafik Ghayor, Nisarat Ruangsawasdi and Franz E. Weber
Materials 2020, 13(3), 501; https://0-doi-org.brum.beds.ac.uk/10.3390/ma13030501 - 21 Jan 2020
Cited by 10 | Viewed by 1880
Abstract
N,N-Dimethylacetamide (DMA) is FDA approved as an excipient and is used as drug-delivery vehicle. Due to its amphipathic nature and diverse bioactivities, it appears to be a good combination of biodegradable poly-lactide-co-glycolide (PLGA)-based guided bone regeneration membranes. Here we show that the [...] Read more.
N,N-Dimethylacetamide (DMA) is FDA approved as an excipient and is used as drug-delivery vehicle. Due to its amphipathic nature and diverse bioactivities, it appears to be a good combination of biodegradable poly-lactide-co-glycolide (PLGA)-based guided bone regeneration membranes. Here we show that the solvent DMA can be loaded to PLGA membranes by different regimes, leading to distinct release profiles, and enhancing the bone regeneration in vivo. Our results highlight the potential therapeutic benefits of DMA in guided bone regeneration procedures, in combination with biodegradable PLGA membranes. Full article
(This article belongs to the Special Issue Advances in Bone Substitute Biology, Production, and Materials)
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14 pages, 4520 KiB  
Article
Effect of Sintering on In Vivo Biological Performance of Chemically Deproteinized Bovine Hydroxyapatite
by Bruno De Carvalho, Eric Rompen, Geoffrey Lecloux, Peter Schupbach, Emilie Dory, Jean-François Art and France Lambert
Materials 2019, 12(23), 3946; https://0-doi-org.brum.beds.ac.uk/10.3390/ma12233946 - 28 Nov 2019
Cited by 19 | Viewed by 2212
Abstract
The influence of the manufacturing process on physicochemical properties and biological performance of xenogenic biomaterials has been extensively studied, but its quantification on bone-to-material contact remains poorly investigated. The aim of this study was to investigate the effect of different heat treatments of [...] Read more.
The influence of the manufacturing process on physicochemical properties and biological performance of xenogenic biomaterials has been extensively studied, but its quantification on bone-to-material contact remains poorly investigated. The aim of this study was to investigate the effect of different heat treatments of an experimental chemically-deproteinized bovine hydroxyapatite in vivo in terms of new bone formation and osteoconductivity. Protein-free hydroxyapatite from bovine origin was produced under sub-critical conditions and then either sintered at 820 °C or 1200 °C. Structural and morphological properties were assessed by scanning electron microscopy (SEM), measurement of surface area and X-ray diffractometry (XRD). The materials were then implanted in standardized alveolar bone defects in minipigs and histomorphometric evaluations were performed using non-decalcified sections. Marked topographical differences were observed by SEM analysis. As the sintering temperature of the experimental material increased, the surface area significantly decreased while crystallite size increased. In vivo samples showed that the highly sintered BHA presented a significantly lower percentage of newly formed bone than the unheated one (p = 0.009). In addition, the percentage of bone-to-material contact (BMC) was significantly lowered in the highly sintered group when compared to the unsintered (p = 0.01) and 820 °C sintered (p = 0.02) groups. Non-sintered or sintered at 820 °C BHA seems to maintain a certain surface roughness allowing better bone regeneration and BMC. On the contrary, sintering of BHA at 1200 °C has an effect on its morphological and structural characteristics and significantly modify its biological performance (osteoconductivity) and crystallinity. Full article
(This article belongs to the Special Issue Advances in Bone Substitute Biology, Production, and Materials)
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Graphical abstract

16 pages, 5753 KiB  
Article
Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing
by José A. Robles-Linares, Erick Ramírez-Cedillo, Hector R. Siller, Ciro A. Rodríguez and J. Israel Martínez-López
Materials 2019, 12(6), 913; https://0-doi-org.brum.beds.ac.uk/10.3390/ma12060913 - 19 Mar 2019
Cited by 30 | Viewed by 11226
Abstract
In this work we present a novel algorithm for generating in-silico biomimetic models of a cortical bone microstructure towards manufacturing biomimetic bone via additive manufacturing. The software provides a tool for physicians or biomedical engineers to develop models of cortical bone that include [...] Read more.
In this work we present a novel algorithm for generating in-silico biomimetic models of a cortical bone microstructure towards manufacturing biomimetic bone via additive manufacturing. The software provides a tool for physicians or biomedical engineers to develop models of cortical bone that include the inherent complexity of the microstructure. The correspondence of the produced virtual prototypes with natural bone tissue was assessed experimentally employing Digital Light Processing (DLP) of a thermoset polymer resin to recreate healthy and osteoporotic bone tissue microstructure. The proposed tool was successfully implemented to develop cortical bone structure based on osteon density, cement line thickness, and the Haversian and Volkmann channels to produce a user-designated bone porosity that matches within values reported from literature for these types of tissues. Characterization of the specimens using a Scanning Electron Microscopy with Focused Ion Beam (SEM/FIB) and Computer Tomography (CT) revealed that the manufacturability of intricated virtual prototype is possible for scaled-up versions of the tissue. Modeling based on the density, inclination and size range of the osteon and Haversian and Volkmann´s canals granted the development of a dynamic in-silico porosity (13.37–21.49%) that matches with models of healthy and osteoporotic bone. Correspondence of the designed porosity with the manufactured assessment (5.79–16.16%) shows that the introduced methodology is a step towards the development of more refined and lifelike porous structures such as cortical bone. Further research is required for validation of the proposed methodology model of the real bone tissue and as a patient-specific customization tool of synthetic bone. Full article
(This article belongs to the Special Issue Advances in Bone Substitute Biology, Production, and Materials)
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