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Biomaterials for Musculoskeletal Tissue Engineering and Regenerative Medicine
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Biomaterials for Musculoskeletal Tissue Engineering and Regenerative Medicine

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 1816

Special Issue Editors

Dr. Abraham Schneider

E-Mail Website
Guest Editor
Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, 650 West Baltimore Street, Room 7265, Baltimore, MD 21201, USA
Interests: mineralized tissue regeneration; dental stem cells; regenerative medicine; AMPK signaling pathway; drug repurposing; head and neck cancer biology
Dr. Michael D. Weir

E-Mail Website
Guest Editor
Department of Advanced Oral Sciences and Therapeutics, Division of Biomaterials and Tissue Engineering, University of Maryland School of Dentistry, 650 West Baltimore Street, Room 6256, Baltimore, MD 21201, USA
Interests: biomaterials; tissue engineering; regenerative medicine; polymers; hydrogels; drug delivery; biomimetic materials

Special Issue Information

Dear Colleagues,

Regeneration of large craniofacial and orthopedic musculoskeletal defects associated with trauma, infection, neoplasia and congenital conditions remains a clinical challenge for oral, maxillofacial and orthopedic surgeons. In recent years, remarkable scientific advances have been made in the development of novel biomaterials, including polymers, ceramics, metals and composites as scaffolds for musculoskeletal tissue regeneration. This Special Issue on “Biomaterials for Musculoskeletal Tissue Engineering and Regenerative Medicine” seeks to highlight the recent progress on biomaterials formulated for craniofacial and orthopedic applications. The scope will include work related to biomaterial synthesis and processing techniques, as well as characterization of the physicochemical and biological properties. Additionally, topics related to the combination of biomaterials, stem cells and biologics for musculoskeletal regenerative medicine will also be included. Special emphasis will be placed on studies with significant clinical translational relevance.

Dr. Abraham Schneider
Dr. Michael D. Weir
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • polymers
  • ceramics
  • metals
  • scaffolds
  • tissue engineering
  • regenerative medicine
  • biocompatibility
  • implant
  • orthopedic
  • craniofacial
  • musculoskeletal
  • osteogenesis
  • chondrogenesis

Published Papers (1 paper)

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Research

16 pages, 13839 KiB  
Article
Modified Histopathological Protocol for Poly-ɛ-Caprolactone Scaffolds Preserving Their Trabecular, Honeycomb-like Structure
by Tomasz Dębski, Juliusz Wysocki, Katarzyna Siennicka, Jakub Jaroszewicz, Karol Szlązak, Wojciech Święszkowski and Zygmunt Pojda
Materials 2022, 15(5), 1732; https://0-doi-org.brum.beds.ac.uk/10.3390/ma15051732 - 25 Feb 2022
Cited by 1 | Viewed by 1443
Abstract
Poly-ɛ-caprolactone (PCL) is now widely studied in relation to the engineering of bone, cartilage, tendons, and other tissues. Standard histological protocols can destroy the carefully created trabecular and honeycomb-like architecture of PCL scaffolds, and could lead to scaffold fibers swelling, resulting in the [...] Read more.
Poly-ɛ-caprolactone (PCL) is now widely studied in relation to the engineering of bone, cartilage, tendons, and other tissues. Standard histological protocols can destroy the carefully created trabecular and honeycomb-like architecture of PCL scaffolds, and could lead to scaffold fibers swelling, resulting in the displacement or compression of tissues inside the scaffold. The aim of this study was to modify a standard histopathological protocol for PCL scaffold preparation and evaluate it on porous cylindrical PCL scaffolds in a rat model. In 16 inbred Wag rats, 2 PCL scaffolds were implanted subcutaneously to both inguinal areas. Two months after implantation, harvested scaffolds were first subjected to μCT imaging, and then to histopathological analysis with standard (left inguinal area) and modified histopathological protocols (right inguinal area). To standardize the results, soft tissue percentages (STPs) were calculated on scaffold cross-sections obtained from both histopathological protocols and compared with corresponding µCT cross-sections. The modified protocol enabled the assessment of almost 10× more soft tissues on the scaffold cross-section than the standard procedure. Moreover, STP was only 1.5% lower than in the corresponding µCT cross-sections assessed before the histopathological procedure. The presented modification of the histopathological protocol is cheap, reproducible, and allows for a comprehensive evaluation of PCL scaffolds while maintaining their trabecular, honeycomb-like structure on cross-sections. Full article
(This article belongs to the Special Issue Biomaterials for Musculoskeletal Tissue Engineering and Regenerative Medicine)
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