Current Treatment and Challenge of Coloanal Disorders

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: closed (20 November 2021) | Viewed by 2881

Special Issue Editor


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Guest Editor
Division of Coloproctology, Department of Surgery, Uijeongbu St. Mary’s Hospital, College of Medicine The Catholic University of Korea, Seoul, Korea
Interests: colon cancer; rectal cancer; immunotherapy; chemotherapy

Special Issue Information

Dear Colleagues,

Amid a flood of information, treatment options for coloanal disorders are growing rapidly. For inflammatory bowel disease (IBD), development of various biologics such as infliximab, adalimumab, and certolizumab pegol, as well as immunomodulators such as azathioprine and 6-Mercaptopurine, has led to improvement in patients’ drug compliance and the prognosis for IBD. As for surgical treatment of colon/rectal diseases, with the rapid development of minimally invasive surgical techniques, particularly for cancer, options for surgical treatment have become diversified including the recent robotic surgeries, thus improving the quality of life of the patients. In particular, the introduction and advancement of robotic surgery have shown oncological results comparable to those of laparoscopic operation, taking into account not only the quality of life of the patients but also the ergonomics of the operator.

Despite the accumulation of such diverse medical knowledge, more medical papers are still needed to establish a global guideline that can be applied to all patients regardless of nationality or race.

Through this Issue, we intend to deal with the contents of coloanal disorder and focus on places with the latest medical opinions covering not only diseases such as IBD but also colon/rectal diseases, including cancer and anal diseases.

Prof. Dr. Seong-taek Oh
Guest Editor

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Keywords

  • inflammatory bowel disease
  • colon cancer
  • rectal cancer
  • chemotherapy
  • anal disease

Published Papers (1 paper)

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Review

29 pages, 463 KiB  
Review
Evaluation and Predictive Factors of Complete Response in Rectal Cancer after Neoadjuvant Chemoradiation Therapy
by Linda Kokaine, Andris Gardovskis and Jānis Gardovskis
Medicina 2021, 57(10), 1044; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57101044 - 30 Sep 2021
Cited by 7 | Viewed by 2586
Abstract
The response to neoadjuvant chemoradiation therapy is an important prognostic factor for locally advanced rectal cancer. Although the majority of the patients after neoadjuvant therapy are referred to following surgery, the clinical data show that complete clinical or pathological response is found in [...] Read more.
The response to neoadjuvant chemoradiation therapy is an important prognostic factor for locally advanced rectal cancer. Although the majority of the patients after neoadjuvant therapy are referred to following surgery, the clinical data show that complete clinical or pathological response is found in a significant proportion of the patients. Diagnostic accuracy of confirming the complete response has a crucial role in further management of a rectal cancer patient. As the rate of clinical complete response, unfortunately, is not always consistent with pathological complete response, accurate diagnostic parameters and predictive markers of tumor response may help to guide more personalized treatment strategies and identify potential candidates for nonoperative management more safely. The management of complete response demands interdisciplinary collaboration including oncologists, radiotherapists, radiologists, pathologists, endoscopists and surgeons, because the absence of a multidisciplinary approach may compromise the oncological outcome. Prediction and improvement of rectal cancer response to neoadjuvant therapy is still an active and challenging field of further research. This literature review is summarizing the main, currently known clinical information about the complete response that could be useful in case if encountering such condition in rectal cancer patients after neoadjuvant chemoradiation therapy, using as a source PubMed publications from 2010–2021 matching the search terms “rectal cancer”, “neoadjuvant therapy” and “response”. Full article
(This article belongs to the Special Issue Current Treatment and Challenge of Coloanal Disorders)
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