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Medicina
Special Issues
Environment and Women's Reproductive Health
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Environment and Women's Reproductive Health

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 6440

Special Issue Editors

Prof. Dr. Donatella Caserta

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences and Translational Medicine, Università degli Studi di Roma La Sapienza, 00185 Rome, Italy
Interests: reproductive medicine; reproductive endocrinology; endometriosis; maternal health
Special Issues, Collections and Topics in MDPI journals
Dr. Ilaria Soave

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences and Translational Medicine, Università degli Studi di Roma La Sapienza, Rome, Italy
Interests: reproductive medicine; endometriosis; assisted reproductive technology; minimal invasive gynecological surgery

Special Issue Information

Dear Colleagues,

Endocrine disrupting chemicals (EDCs), also known as endocrine disruptors, are defined as exogenous substances or mixtures that can interfere with any aspect of hormone action. Over the last two decades, increasing attention has been paid to EDCs and their effects on the female reproductive system. More than 800 chemicals have been classified as EDCs, including drugs, pesticides, polychlorinated biphenyls, dioxin, dioxin-like compounds, plasticizers, and heavy metals, and the list is growing rapidly. These chemicals are present in common industrial and home products (food plastic containers, cans, clothes, toys, cosmetics, furniture) and also possess a high potential for bioaccumulation in the food web. Therefore, humans are continually exposed and contact with them has become inevitable. The purpose of this Special Issue is to highlight their effect on women’s reproductive health (fertility, sexual development, placental transmission, obstetrical complications, and carcinogenesis).

Prof. Dr. Donatella Caserta
Dr. Ilaria Soave
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Endocrine disrupting chemical
  • Endocrine disruptor
  • Environment
  • Human exposure
  • Female fertility
  • Women’s health
  • Placental transmission
  • Carcinogenesis

Published Papers (2 papers)

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Research

10 pages, 458 KiB  
Article
How Perfectionism and Eating Disorder Symptoms Contribute to Searching Weight-Loss Information on the Internet?
by Katarina Prnjak, Ivan Jukic and Anita Lauri Korajlija
Medicina 2019, 55(10), 621; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina55100621 - 23 Sep 2019
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Abstract
Background and Objectives: Eating disorder (ED) symptoms are a growing problem and modern technologies introduced a new and unexplored potential risk factor for vulnerable individuals. It is fairly common for women to use the Internet in order to find information about various weight-loss [...] Read more.
Background and Objectives: Eating disorder (ED) symptoms are a growing problem and modern technologies introduced a new and unexplored potential risk factor for vulnerable individuals. It is fairly common for women to use the Internet in order to find information about various weight-loss methods, but it was further questioned whether perfectionism and eating disorder symptomatology could be linked to this behavior. Materials and Methods: Participants were 228 women (Mean age = 30.5; SD = 9.43) recruited via social media, who provided responses on measures of perfectionism, eating disorder symptoms, and a short check-list measuring the frequency of online searching about five topics (food, diet, exercise, body appearance, and eating disorders). Results: Hierarchical multiple regression analysis showed that the BMI and Discrepancy subscale of APS-R significantly predicted online searching, along with eating disorder symptomatology. Moreover, mediation analyses resulted in a significant indirect effect, but not a direct effect, indicating that eating disorder symptomatology fully mediated the relationship between BMI and online searching, as well as between maladaptive perfectionism and online searching. Conclusion: These findings shed light on a high BMI and maladaptive perfectionism as potential risk factors for eating disorder-related behavior on the Internet. More attention to online-seeking behavior among women symptomatic of ED is warranted, and websites containing such topics should include information about professional help for eating disorder-symptomatic individuals. Full article
(This article belongs to the Special Issue Environment and Women's Reproductive Health)
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12 pages, 3410 KiB  
Article
Proliferation in Postmenopausal Endometrial Polyps—A Potential for Malignant Transformation
by Lina Adomaitienė, Rūta Nadišauskienė, Mahshid Nickkho-Amiry, Arvydas Čižauskas, Jolita Palubinskienė, Cathrine Holland and Mourad W Seif
Medicina 2019, 55(9), 543; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina55090543 - 28 Aug 2019
Cited by 10 | Viewed by 3023
Abstract
Background and objectives: Endometrial polyps in asymptomatic postmenopausal women are often incidentally found, yet only 1.51% of them are malignant. Their potential for malignant transformation has not been adequately addressed. The aim of this study was to investigate the proliferation within endometrial polyps [...] Read more.
Background and objectives: Endometrial polyps in asymptomatic postmenopausal women are often incidentally found, yet only 1.51% of them are malignant. Their potential for malignant transformation has not been adequately addressed. The aim of this study was to investigate the proliferation within endometrial polyps as one of the indicators of their malignization potential in asymptomatic postmenopausal women. Materials and Methods: Immunohistochemical studies of Ki-67 were performed. Cases included 52 benign postmenopausal polyps, 19 endometrioid carcinoma with coexisting benign polyps, 12 polyps with foci of carcinoma and 4 cases of polyps, which later developed carcinoma. The control group included 31 atrophic endometria and 32 benign premenopausal polyps. Ki-67 was scored in either 10 or 20 “hot spot” fields, as percentage of positively stained cells. Results: The median epithelial Ki-67 score in postmenopausal benign polyps (4.7%) was significantly higher than in atrophic endometria (2.41%, p < 0.0001) and significantly lower than in premenopausal benign polyps (11.4%, p = 0.003) and endometrial cancer (8.3%, p < 0.0001). Where endometrial polyps were found in association with endometrial carcinoma, Ki-67 was significantly higher in cancer (p < 0.0001). No significant difference was found between Ki-67 scores of cancer focus and of the polyps tissue itself, respectively 2.8% and 4.55%, p = 0.37. Ki-67 expression, where polyps were resected and women later developed cancer, was not significantly different (p = 0.199). Conclusion: Polyps from asymptomatic postmenopausal women showed significantly more proliferation in both epithelial and stromal components than inactive atrophic endometria but less than premenopausal benign polyps and/or endometrial cancer. Benign postmenopausal endometrial polyps exhibit low proliferative activity, suggesting low malignant potential and may not require resection in asymptomatic women. Full article
(This article belongs to the Special Issue Environment and Women's Reproductive Health)
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