Metabolomics: An Emerging Potential Approach to Study Critical Illnesses, 2nd Edition

Dear Colleagues,

The reasons for the disproportionately high number of negative randomized controlled trials in critical illness extend beyond improving methodologies, power, and appropriate outcome measurements. Rather, the heterogeneous and dynamic nature of critical illness makes it challenging to prospectively design observational research and clinical trials, limiting our ability to find high-quality therapies to improve outcomes. Instead, precision medicine approaches rooted in translational -omics science, health informatics, and predictive analytics are required to develop targeted, effective therapies and improve patient outcomes.

Recently, efforts have been made to phenotype critical illnesses such as sepsis, a shift away from previous efforts to evaluate treatments and prognostic markers in broadly chosen groups of patients. These efforts suggest that disease phenotypes are not as uniform as previously believed, and as such, different treatments are required for patients with different disease phenotypes. Metabolomics and metabolic phenotyping are reflective of interactions between an individual’s genetics, gut microbiome, and environment (e.g., diet, pharmaceuticals/medical interventions, and exposures) and are well suited to characterizing an individual’s health status at a given point in time or a patient’s response to therapeutic interventions.

Topics of particular interest include, but are not limited to, studies using metabolomics to phenotype critically ill patients, to evaluate patients’ clinical trajectories, to evaluate specific interventions, and to evaluate prognostic and/or diagnostic biomarkers.

Dr. Helen G. Gika
Dr. Pousinis Petros
Guest Editors

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• metabolomics
• metabolic phenotype
• critical illness
• sepsis precision medicine
• pharmacometabolomics

• Metabolomics: An Emerging Potential Approach to Study Critical Illnesses in Metabolites (4 articles)