Mitochondrial Metabolism and Oxidative Stress in Hypertension, Diabetes and Related Complications

Dear Colleagues,

Alterations in mitochondrial energy metabolism are one of the underlying causes in the development of diabetes and hypertension and its complications. Mitochondrial dysfunction increases the production of reactive oxygen species (ROS) to deleterious levels and activates various mechanisms that result in tissue damage in both diseases. The dysfunction of mitochondrial energy metabolism in turn negatively alters other processes, further disrupting cellular homeostasis, including mitophagy, autophagy and cell death processes such as apoptosis, necrosis or ferroptosis. This Special Issue is devoted to such topics, including (not exclusively) studies on alterations in the mitochondrial metabolic profile, mitochondrial energy metabolism and mitochondrial oxidative stress in diabetes and hypertension. Topics such as the dysregulation of mitochondrial dynamics (fusion/fission), mitochondrial quality control (mitophagy) and cell death (apoptosis, necrosis, ferroptosis) in diabetes and hypertension are also welcome. The therapeutic use of drugs, nutraceuticals and functional foods for the control of these alterations in diabetes and hypertension is also covered.

Prof. Dr. Christian Cortés-Rojo
Guest Editor

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• diabetes
• hypertension
• ROS
• oxidative stress
• cell death
• inflammation
• mitochondrial control quality
• mitochondrial dynamics
• mitochondria-targeted molecules
• nutraceuticals and functional foods