Emerging Applications of Urinary Metabolomics in Cancer

Dear Colleagues,

The rapid emergence of urinary metabolomics as a powerful platform for biomarker discovery shows transformative potential to revolutionize the study of cancer metabolism, early detection, and therapeutic response monitoring, among other applications. The clinical value of urinary metabolites rests in the relative ease of their noninvasive collection and analysis, providing seamless integration with existing clinical laboratory workflows. However, significant challenges relating to the variability in urinary metabolites in response to various internal and external factors continue to complicate their development as novel cancer biomarkers.

This Special Issue aims to highlight novel applications of urinary metabolomics to the study of cancer metabolism, including metabolomics profiling, metabolic pathway identification, and disease etiology; biomarker discovery and validation, including early cancer detection, disease risk stratification, therapeutic response prediction, and therapeutic response monitoring; and advances to overcome technical barriers in the field, including the development of advanced analytical techniques, normalization of urinary metabolite variability, replication across clinical populations, and statistical methods to aid translational and clinical research. In this way, this Special Issue seeks to provide an overview of the latest advances in the application of urinary metabolomics to improve our understanding of cancer and its clinical detection and treatment.

Dr. Casey Burton
Guest Editor

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• urinary metabolomics
• cancer biomarkers
• early cancer detection
• analytical method development
• therapeutic response monitoring