The Regulation of Adiponectin Secretion in White Adipocytes—in Metabolic Health and Disease

Dear Colleagues,

The adipocyte hormone adiponectin is a chief regulator of cell- and whole-body energy homeostasis and metabolism. Adiponectin is a complex hormone that exists in the circulation as oligomeric high-molecular weight adiponectin (HMW) and as medium and low molecular weight hexamers and trimers. Circulating levels of adiponectin are typically decreased in obese and/or diabetic individuals and preserved adiponectin levels have been associated with lower incidence of obesity-linked metabolic diseases, such as type 2 diabetes. Although its role in metabolic regulation is rather extensively investigated, the current understanding of the production and secretion of adiponectin is incomplete.

This Special Issue of Metabolites will be dedicated to any aspect of the regulation of adipocyte adiponectin release, in metabolic health and disease. Topics that will be covered include, but are not limited to, the cellular and molecular control of adiponectin exocytosis, secretagouge-induced release of adiponectin, intracellular processes that govern the secretion of adiponectin as well as how different adipose tissue depots contribute to the secretion and circulating levels of adiponectin molecular forms.

Dr. Charlotta S. Olofsson
Guest Editor

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