Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
3.4
Journals
Micromachines
Special Issues
Frontiers in Biosensors
share announcement

Frontiers in Biosensors

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B1: Biosensors".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 14290

Special Issue Editor

Prof. Dr. Van Thuan Nguyen

E-Mail Website
Guest Editor
Department of Biology, Western Kentucky University, Bowling Green, KY 42101, USA
Interests: aptamer; aptasensor; lateral flow cartridges; wearable biosensors; emerging biosensors; POC biosensors; nanobiosensors; DNA chips; microarray; gene expression; cancer cell therapeutics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors have grown exponentially and been developed broadly for the detection of food toxicity, medical diagnosis, chemical contamination, environmental monitoring, and other emerging applications. Although there have been a lot of achievements and improvements in developing biosensors for utilizing high sensitivity or selectivity and the rapid detection of biomolecule markers, there is still a great need for portable, automatic, field-deployable, and highly robust technologies. This Special Issue is dedicated to presenting the latest research on biosensor-relevant healthcare systems, early medical diagnostics, and environmental monitoring such as wearable biosensors, emerging biosensors, diagnostic pathogenic diseases, ultra-sensitive technologies, highly robust technologies, POC biosensors, nanobiosensors, and AI biosensors.

Prof. Dr. Van Thuan Nguyen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wearable biosensors emerging biosensors
  • POC biosensors
  • nanobiosensors
  • AI biosensors
  • ultra-sensitive technologies
  • smartphone technologies

Published Papers (7 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 848 KiB  
Communication
Microbial Biosensor for Characterization of a Microorganism: A Review focusing on the Biochemical Activity of Microbial Cells
by Elena Emelyanova
Micromachines 2023, 14(4), 733; https://0-doi-org.brum.beds.ac.uk/10.3390/mi14040733 - 25 Mar 2023
Viewed by 1091
Abstract
Express assessment of the biochemical activity of microorganisms is important in both applied and fundamental research. A laboratory model of a microbial electrochemical sensor formed on the basis of the culture of interest is a device that provides rapidly information about the culture [...] Read more.
Express assessment of the biochemical activity of microorganisms is important in both applied and fundamental research. A laboratory model of a microbial electrochemical sensor formed on the basis of the culture of interest is a device that provides rapidly information about the culture and is cost effective, simple to fabricate and easy to use. This paper describes the application of laboratory models of microbial sensors in which the Clark-type oxygen electrode was used as a transducer. The formation of the models of the reactor microbial sensor (RMS) and the membrane microbial sensor (MMS) and the formation of the response of biosensors are compared. RMS and MMS are based on intact or immobilized microbial cells, respectively. For MMS, the response of biosensor is caused both by the process of transport of substrate into microbial cells and by the process of the initial metabolism of substrate; and only initial substrate metabolism triggers the RMS response. The details of the application of biosensors for the study of allosteric enzymes and inhibition by substrate are discussed. For inducible enzymes, special attention is paid to the induction of microbial cells. This article addresses current problems related to implementation of the biosensor approach and discusses the ways how to overcome these problems. Full article
(This article belongs to the Special Issue Frontiers in Biosensors)
►▼ Show Figures

Figure 1

12 pages, 2597 KiB  
Article
Handling Detection Limits of Multiplex Lateral Flow Immunoassay by Choosing the Order of Binding Zones
by Anastasiya V. Bartosh, Dmitriy V. Sotnikov, Anatoly V. Zherdev and Boris B. Dzantiev
Micromachines 2023, 14(2), 333; https://0-doi-org.brum.beds.ac.uk/10.3390/mi14020333 - 28 Jan 2023
Viewed by 1223
Abstract
Changes in the limits of detection (LODs) for a multiplex lateral flow immunoassay (LFIA) caused by different locations of the binding zone on the test strips were studied. Due to the non-equilibrium conditions of the immune reactions in LFIAs, their analytical parameters are [...] Read more.
Changes in the limits of detection (LODs) for a multiplex lateral flow immunoassay (LFIA) caused by different locations of the binding zone on the test strips were studied. Due to the non-equilibrium conditions of the immune reactions in LFIAs, their analytical parameters are susceptible to the binding constants of antigen–antibody reactions and assay duration. Consequently, the integration of several tests into one multiplex assay can cause a significant worsening of the sensitivity. In this study, we propose a simple methodology for the determination of the best arrangement of binding zones, which takes into account the binding constants for immunoreagents. LFIAs of four mycotoxins, namely, aflatoxin B1, deoxynivalenol, T-2 toxin, and ochratoxin A, were integrated into a multiplex test strip. An enzyme-linked immunosorbent assay was applied to determine the equilibrium and kinetic constants of the immunoreactants for each analyte. It was found that the arrangement of binding zones with a descending order of the equilibrium association constants was optimal and provided both lower detection limits and a more uniform coloration. The selected position of the binding zones allowed decreasing the LODs down to 2 and 27 times for ochratoxin A and deoxynivalenol, respectively. The proposed approach can be applied to multiplex LFIAs for different analytes. Full article
(This article belongs to the Special Issue Frontiers in Biosensors)
►▼ Show Figures

Figure 1

20 pages, 4022 KiB  
Article
Paper-Based Multiplex Sensors for the Optical Detection of Plant Stress
by Marie Zedler, Sze Wai Tse, Antonio Ruiz-Gonzalez and Jim Haseloff
Micromachines 2023, 14(2), 314; https://0-doi-org.brum.beds.ac.uk/10.3390/mi14020314 - 26 Jan 2023
Cited by 2 | Viewed by 1576
Abstract
The rising population and the ongoing climate crisis call for improved means to monitor and optimise agriculture. A promising approach to tackle current challenges in food production is the early diagnosis of plant diseases through non-invasive methods, such as the detection of volatiles. [...] Read more.
The rising population and the ongoing climate crisis call for improved means to monitor and optimise agriculture. A promising approach to tackle current challenges in food production is the early diagnosis of plant diseases through non-invasive methods, such as the detection of volatiles. However, current devices for detection of multiple volatiles are based on electronic noses, which are expensive, require complex circuit assembly, may involve metal oxides with heating elements, and cannot easily be adapted for some applications that require miniaturisation or limit front-end use of electronic components. To address these challenges, a low-cost optoelectronic nose using chemo-responsive colorimetric dyes drop-casted onto filter paper has been developed in the current work. The final sensors could be used for the quantitative detection of up to six plant volatiles through changes in colour intensities with a sub-ppm level limit of detection, one of the lowest limits of detection reported so far using colorimetric gas sensors. Sensor colouration could be analysed using a low-cost spectrometer and the results could be processed using a microcontroller. The measured volatiles could be used for the early detection of plant abiotic stress as early as two days after exposure to two different stresses: high salinity and starvation. This approach allowed a lowering of costs to GBP 1 per diagnostic sensing paper. Furthermore, the small size of the paper sensors allows for their use in confined settings, such as Petri dishes. This detection of abiotic stress could be easily achieved by exposing the devices to living plants for 1 h. This technology has the potential to be used for monitoring of plant development in field applications, early recognition of stress, implementation of preventative measures, and mitigation of harvest losses. Full article
(This article belongs to the Special Issue Frontiers in Biosensors)
►▼ Show Figures

Figure 1

23 pages, 11586 KiB  
Article
A 100 KS/s 8–10-Bit Resolution-Reconfigurable SAR ADC for Biosensor Applications
by Yunfeng Hu, Lexing Hu, Bin Tang, Bin Li, Zhaohui Wu and Xiaojia Liu
Micromachines 2022, 13(11), 1909; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13111909 - 05 Nov 2022
Cited by 1 | Viewed by 1379
Abstract
A DAC switching scheme that combines energy efficiency and resolution reconfigurability is proposed. Compared with the conventional switching scheme, the proposed scheme achieves 93.8%, 96.1%, and 97.3% switching energy saving in 8-bit, 9-bit, and 10-bit modes, respectively. Based on the proposed switching scheme, [...] Read more.
A DAC switching scheme that combines energy efficiency and resolution reconfigurability is proposed. Compared with the conventional switching scheme, the proposed scheme achieves 93.8%, 96.1%, and 97.3% switching energy saving in 8-bit, 9-bit, and 10-bit modes, respectively. Based on the proposed switching scheme, an 8–10-bit resolution-reconfigurable SAR ADC for biosensor applications is designed. The ADC consists of resolution-reconfigurable binary-weighted capacitive DAC, a two-stage full dynamic comparator, sampling switch, and the resolution-control SAR logic. Simulated in 180 nm CMOS process and 100 kS/s sampling rate, the ADC achieves the 46.80/53.89/60.14 dB signal-to-noise and distortion ratio (SNDR), the 55.22/62.51/73.09 dB spurious-free dynamic range (SFDR) and the 0.81/0.91/1.01 μW power consumption in 8/9/10-bit mode, respectively. Full article
(This article belongs to the Special Issue Frontiers in Biosensors)
►▼ Show Figures

Figure 1

Review

Jump to: Research

33 pages, 8300 KiB  
Review
Status and Prospects of Heterojunction-Based HEMT for Next-Generation Biosensors
by Najihah Fauzi, Rahil Izzati Mohd Asri, Mohamad Faiz Mohamed Omar, Asrulnizam Abd Manaf, Hiroshi Kawarada, Shaili Falina and Mohd Syamsul
Micromachines 2023, 14(2), 325; https://0-doi-org.brum.beds.ac.uk/10.3390/mi14020325 - 27 Jan 2023
Cited by 5 | Viewed by 2398
Abstract
High electron mobility transistor (HEMT) biosensors hold great potential for realizing label-free, real-time, and direct detection. Owing to their unique properties of two-dimensional electron gas (2DEG), HEMT biosensors have the ability to amplify current changes pertinent to potential changes with the introduction of [...] Read more.
High electron mobility transistor (HEMT) biosensors hold great potential for realizing label-free, real-time, and direct detection. Owing to their unique properties of two-dimensional electron gas (2DEG), HEMT biosensors have the ability to amplify current changes pertinent to potential changes with the introduction of any biomolecules, making them highly surface charge sensitive. This review discusses the recent advances in the use of AlGaN/GaN and AlGaAs/GaAs HEMT as biosensors in the context of different gate architectures. We describe the fundamental mechanisms underlying their operational functions, giving insight into crucial experiments as well as the necessary analysis and validation of data. Surface functionalization and biorecognition integrated into the HEMT gate structures, including self-assembly strategies, are also presented in this review, with relevant and promising applications discussed for ultra-sensitive biosensors. Obstacles and opportunities for possible optimization are also surveyed. Conclusively, future prospects for further development and applications are discussed. This review is instructive for researchers who are new to this field as well as being informative for those who work in related fields. Full article
(This article belongs to the Special Issue Frontiers in Biosensors)
►▼ Show Figures

Figure 1

16 pages, 4451 KiB  
Review
Sensors for Detection of the Synthetic Dye Rhodamine in Environmental Monitoring Based on SERS
by Nguyen Tran Truc Phuong, Thuy-An Nguyen, Vu Thi Huong, Le Hong Tho, Do Thao Anh, Hanh Kieu Thi Ta, Tran Huu Huy, Kieu The Loan Trinh and Nhu Hoa Thi Tran
Micromachines 2022, 13(11), 1840; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13111840 - 27 Oct 2022
Cited by 8 | Viewed by 2240
Abstract
This article presents a review of many types of SERS sensors for food safety and environmental pollution monitoring based on detecting rhodamine. It introduces the basic concepts of substrates, enhancement factors, and mechanisms, devices’ sensors integrated with the microstructure. Here, we review the [...] Read more.
This article presents a review of many types of SERS sensors for food safety and environmental pollution monitoring based on detecting rhodamine. It introduces the basic concepts of substrates, enhancement factors, and mechanisms, devices’ sensors integrated with the microstructure. Here, we review the state-of-the-art research in the field of rhodamine monitoring and highlight the applications of SERS sensors. The trends in the development of substrates for different applications have been mentioned with the aim of providing an overview of the development of different SERS substrates. Thus, an efficient approach for rhodamine detection has a good perspective for application in environmental monitoring. Full article
(This article belongs to the Special Issue Frontiers in Biosensors)
►▼ Show Figures

Figure 1

28 pages, 3148 KiB  
Review
Cancer Diagnostics and Early Detection Using Electrochemical Aptasensors
by Joel Imoukhuede Omage, Ethan Easterday, Jelonia T. Rumph, Imamulhaq Brula, Braxton Hill, Jeffrey Kristensen, Dat Thinh Ha, Cristi L. Galindo, Michael K. Danquah, Naiya Sims and Van Thuan Nguyen
Micromachines 2022, 13(4), 522; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13040522 - 26 Mar 2022
Cited by 13 | Viewed by 3346
Abstract
The detection of early-stage cancer offers patients the best chance of treatment and could help reduce cancer mortality rates. However, cancer cells or biomarkers are present in extremely small amounts in the early stages of cancer, requiring high-precision quantitative approaches with high sensitivity [...] Read more.
The detection of early-stage cancer offers patients the best chance of treatment and could help reduce cancer mortality rates. However, cancer cells or biomarkers are present in extremely small amounts in the early stages of cancer, requiring high-precision quantitative approaches with high sensitivity for accurate detection. With the advantages of simplicity, rapid response, reusability, and a low cost, aptamer-based electrochemical biosensors have received considerable attention as a promising approach for the clinical diagnosis of early-stage cancer. Various methods for developing highly sensitive aptasensors for the early detection of cancers in clinical samples are in progress. In this article, we discuss recent advances in the development of electrochemical aptasensors for the early detection of different cancer biomarkers and cells based on different detection strategies. Clinical applications of the aptasensors and future perspectives are also discussed. Full article
(This article belongs to the Special Issue Frontiers in Biosensors)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-7
Back to TopTop