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Microorganisms
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Yeast Mitochondria
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Yeast Mitochondria

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 5444

Special Issue Editor

Prof. Dr. Renata A. Zvyagilskaya

E-Mail Website
Guest Editor
Bach Institute of Biochemistry, Fundamentals of Biotechnology Federal Research Center, Russian Academy of Sciences, Moscow 119071, Russia
Interests: yeast; mitochondria; bioenergetics; mitochondrial dynamics; mitophagy; apoptosis; oxidative stress; yeast models for neurodegenerative pathologies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Yeasts, simple unicellular eukaryotic organisms, share well-conserved molecular and cellular mechanisms of eukaryotic cell biology. These include commonalities in their underlying molecular makeup, in mechanisms governing cell signaling pathways, protein folding, quality control and degradation, and vesicular trafficking. Moreover, yeasts, thanks to their relative simplicity, vigorous growth on well-defined and low-cost substrates, inherent tractability, ease of genetic manipulation, and high-throughput screening technologies, have become a valuable and prevalent eukaryotic model for deciphering the human biology and pathologies.  

Mitochondria are essential organelles with versatile functions in cellular metabolism and homeostasis. In addition to being the best-known function as main producers of energy, they are fully integrated into the cellular metabolism and take part in maintaining cell signaling, cell adaption to external stressors, modulation of ROS signaling and maintaining oxidative homeostasis, and regulation of apoptosis. Recently, not only yeast cells, but also yeast mitochondria, have become a platform for gaining new knowledge with shared value. Using yeast cells as model organisms, much progress has been made in analyzing mitochondrial proteome, following the behavior of individual mitochondria, revealing multiple organelle–membrane tethering sites/factors, such as ER–mitochondria encounter structure, vacuole and mitochondria patch, and mitochondrial contact sites and mitochondrial DNA editing. Additionally, a better understanding of regulatory mechanisms governing mitochondrial biogenesis, mitochondrial motility, mother–daughter age asymmetry, and quantity and quality control of mitochondria in general and during cell cycle progression has been achieved.  

This Special Issue on “Yeast Mitochondria” aims to highlight the latest scientific advances in this exciting field, put them together, and promote them by inviting original updated contributions and review papers.

Prof. Renata A. Zvyagilskaya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Yeast
  • Mitochondria
  • Bioenergetics
  • Mitochondrial proteome
  • Mitochondrial DNA editing
  • Mitophagy
  • Mitochondrial dynamics

Published Papers (2 papers)

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Research

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19 pages, 3410 KiB  
Article
The First Yarrowia lipolytica Yeast Models Expressing Hepatitis B Virus X Protein: Changes in Mitochondrial Morphology and Functions
by Khoren K. Epremyan, Tatyana N. Goleva, Anton G. Rogov, Svetlana V. Lavrushkina, Roman A. Zinovkin and Renata A. Zvyagilskaya
Microorganisms 2022, 10(9), 1817; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms10091817 - 10 Sep 2022
Cited by 3 | Viewed by 1890
Abstract
Chronic hepatitis B virus infection is the dominant cause of hepatocellular carcinoma, the main cause of cancer death. HBx protein, a multifunctional protein, is essential for pathogenesis development; however, the underlying mechanisms are not fully understood. The complexity of the system itself, and [...] Read more.
Chronic hepatitis B virus infection is the dominant cause of hepatocellular carcinoma, the main cause of cancer death. HBx protein, a multifunctional protein, is essential for pathogenesis development; however, the underlying mechanisms are not fully understood. The complexity of the system itself, and the intricate interplay of many factors make it difficult to advance in understanding the mechanisms underlying these processes. The most obvious solution is to use simpler systems by reducing the number of interacting factors. Yeast cells are particularly suitable for studying the relationships between oxidative stress, mitochondrial dynamics (mitochondrial fusion and fragmentation), and mitochondrial dysfunction involved in HBx-mediated pathogenesis. For the first time, genetically modified yeast, Y. lipolytica, was created, expressing the hepatitis B virus core protein HBx, as well as a variant fused with eGFP at the C-end. It was found that cells expressing HBx experienced stronger oxidative stress than the control cells. Oxidative stress was alleviated by preincubation with the mitochondria-targeted antioxidant SkQThy. Consistent with these data, in contrast to the control cells (pZ-0) containing numerous mitochondrial forming a mitochondrial reticulum, in cells expressing HBx protein, mitochondria were fragmented, and preincubation with SkQThy partially restored the mitochondrial reticulum. Expression of HBx had a significant influence on the bioenergetic function of mitochondria, making them loosely coupled with decreased respiratory rate and reduced ATP formation. In sum, the first highly promising yeast model for studying the impact of HBx on bioenergy, redox-state, and dynamics of mitochondria in the cell and cross-talk between these parameters was offered. This fairly simple model can be used as a platform for rapid screening of potential therapeutic agents, mitigating the harmful effects of HBx. Full article
(This article belongs to the Special Issue Yeast Mitochondria)
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Review

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33 pages, 1308 KiB  
Review
Learning from Yeast about Mitochondrial Carriers
by Marek Mentel, Petra Chovančíková, Igor Zeman and Peter Polčic
Microorganisms 2021, 9(10), 2044; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9102044 - 28 Sep 2021
Cited by 4 | Viewed by 2707
Abstract
Mitochondria are organelles that play an important role in both energetic and synthetic metabolism of eukaryotic cells. The flow of metabolites between the cytosol and mitochondrial matrix is controlled by a set of highly selective carrier proteins localised in the inner mitochondrial membrane. [...] Read more.
Mitochondria are organelles that play an important role in both energetic and synthetic metabolism of eukaryotic cells. The flow of metabolites between the cytosol and mitochondrial matrix is controlled by a set of highly selective carrier proteins localised in the inner mitochondrial membrane. As defects in the transport of these molecules may affect cell metabolism, mutations in genes encoding for mitochondrial carriers are involved in numerous human diseases. Yeast Saccharomyces cerevisiae is a traditional model organism with unprecedented impact on our understanding of many fundamental processes in eukaryotic cells. As such, the yeast is also exceptionally well suited for investigation of mitochondrial carriers. This article reviews the advantages of using yeast to study mitochondrial carriers with the focus on addressing the involvement of these carriers in human diseases. Full article
(This article belongs to the Special Issue Yeast Mitochondria)
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