Advances in Cytoprotective Drug Discovery II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 4275
Special Issue Editor
Interests: bioactive compounds; secondary metabolites; marine invertebrates; marine fungi; cytoprotection; cytotoxicity; structure–activity relationships
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The ongoing COVID-19 pandemic has raised the challenge of creating effective cytoprotective drugs that protect the cells of the heart, brain, lungs and other organs from the damaging effects of infections. Furthermore, the impact of physical factors, such as high levels of ultraviolet radiation and suspended particles in the polluted air of megacities, cannot be ignored. Cellular defense mechanisms have been studied to some extent and are known to include autophagy, C-protein activation, the endoplasmic reticulum shock response system, cell antioxidant and anti-inflammatory systems and others. Thus, information on natural and synthetic compounds capable of activating these protective molecular mechanisms is extremely important for the discovery of cytoprotective drugs.
Indeed, natural objects are the most valuable source of cytoprotective substances since they are in constant competition for existence and produce both secondary metabolites with a toxic effect for "attack" activities and cytoprotective secondary metabolites for self-defense. A deep chemical understanding of micro- and macro-organisms and the possibility of organic synthesis can help pave the way for necessary solutions.
The second edition of the Special Issue will provide a platform for articles describing the isolation and identification of various demonstrated types of cytoprotective effects of natural products, as well as the study of cytoprotective synthetic compounds. In addition, manuscripts describing the molecular mechanism of the cytoprotective action of promising drug candidates are welcome.
Dr. Ekaterina Yurchenko
Guest Editor
Manuscript Submission Information
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Keywords
- cytoprotection
- cardioprotection
- antioxidants
- hepatoprotection
- skin protection
- lung protection
- natural products
- drug candidates
