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Repurposing Drugs and Molecules with Anti-cancer and Immunomodulatory Effects

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 4651

Special Issue Editor


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Guest Editor
College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea
Interests: repurposing drugs; dendritic cells; adjuvants; vaccine; immunomodulation

Special Issue Information

Dear Colleagues,

Repurposing drugs are drugs with additional effects other than the those used to treat the indications they were originally approved for in clinics. Finding repurposing drugs is a method to provide therapies in clinical fields where there are few suitable treatments. In this Special Issue, we welcome submissions of original research articles or review articles on repurposing drugs or molecules with anti-cancer, anti-inflammatory, and immunomodulatory effects in addition to their original medicinal effects.

Prof. Dr. Hong-Gu Joo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • repurposing drugs
  • molecules
  • anti-cancer
  • anti-inflammatory
  • immunomodulatory

Published Papers (1 paper)

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Review

17 pages, 3346 KiB  
Review
Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy
by Kewang Luo, Ning Li, Wei Ye, Hanchao Gao, Xinle Luo and Baohui Cheng
Molecules 2022, 27(14), 4638; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27144638 - 20 Jul 2022
Cited by 16 | Viewed by 4293
Abstract
Stimulator of interferon gene (STING), an intracellular receptor in the endoplasmic reticulum, could induce the production of cytokines such as type I interferon (IFN) by activating the cGAS-STING signal pathway. In recent years, activation of STING has shown great potential to enhance anti-tumor [...] Read more.
Stimulator of interferon gene (STING), an intracellular receptor in the endoplasmic reticulum, could induce the production of cytokines such as type I interferon (IFN) by activating the cGAS-STING signal pathway. In recent years, activation of STING has shown great potential to enhance anti-tumor immunity and reshape the tumor microenvironment, which is expected to be used in tumor immunotherapy. A number of STING agonists have demonstrated promising biological activity and showed excellent synergistic anti-tumor effects in combination with other cancer therapies in preclinical studies and some clinical trials. The combination of STING agonists and ICI also showed a potent effect in improving anti-tumor immunity. In this review, we introduce the cGAS-STING signaling pathway and its effect in tumor immunity and discuss the recent strategies of activation of the STING signaling pathway and its research progress in tumor immunotherapy. Full article
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