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Green Analytical Chemistry in Bioactive Compounds Analysis: Past, Present, and Future

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 3288

Special Issue Editor


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Guest Editor
Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Medicine and Pharmacy Iuliu Hatieganu Cluj-Napoca, Victor Babes, 8, Cluj-Napoca, Romania
Interests: spectroscopy; chromatography; mass spectrometry; plants bioactive compounds; antioxidant activity; oxidative stress and inflammation; cardiovascular diseases
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Special Issue Information

Dear Colleagues,

Green analytical chemistry (GAC) is derived from green chemistry and is mainly oriented towards the use of environmentally friendly laboratory practices with no concessions regarding the instrumentation and methodology quality. The main goal of green chemistry is to design products and introduce specific manufacturing processes that are reducing the negative effects on both human health and the environment. In this context, the concept of green chemistry is strongly connected to the idea of sustainable development because nowadays the ultimate goal is to minimize the impact of human actions, which have been causing environmental side effects for years.

The design of new processes or the adaptation of existing technologies into green ones is always guided by the principles of green chemistry. The most notable of these principles are the elimination or reduction of reagents and solvent consumption, the reduction of vapours and gaseous emissions, the reduction or elimination of highly toxic reagents, and finally the reduction of energy consumption.

A practical application of GAC is its capacity to offer an innovative approach in many related areas such as the medical, pharmaceutical, agricultural, and food industries. Thus, the use of GAC techniques in natural bioactive compounds discovery, their isolation, identification, and analysis can be the start of their involvement in all related applications, making them an important part of the development of a sustainable future.

This Special Issue will focus on the implications of using GAC techniques in bioactive compound extraction techniques such as supercritical fluid extraction, pressurized liquid extraction, ultrasound-assisted extraction, microwave assisted extraction, solid phase extraction, and solid phase microextraction as well as high throughput identification analytical techniques like ultra-performance liquid chromatography coupled with mass spectrometry, UV-vis, and infrared spectroscopy. Additionally, articles discussing recent advances, new applications, and future perspectives of GAC used in bioactive compound analysis and identification are welcome.

Dr. Raluca Maria Pop
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plants bioactive compounds
  • green extraction methods
  • detection
  • sustainability

Published Papers (1 paper)

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Research

14 pages, 1499 KiB  
Article
Carotenoid Recovery from Tomato Processing By-Products through Green Chemistry
by Katalin Szabo, Bernadette-Emőke Teleky, Floricuta Ranga, Ioana Roman, Hattab Khaoula, Emna Boudaya, Amina Ben Ltaief, Wael Aouani, Mangkorn Thiamrat and Dan Cristian Vodnar
Molecules 2022, 27(12), 3771; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27123771 - 11 Jun 2022
Cited by 20 | Viewed by 2756
Abstract
The recovery of bioactive compounds from agro-industry-derived by-products sustains circular economy principles by encouraging maximized recycling and minimized waste. Tomato processing by-products are abundant in carotenoids, which have several health-promoting properties, and their reintegration into functional food products represents a major interest for [...] Read more.
The recovery of bioactive compounds from agro-industry-derived by-products sustains circular economy principles by encouraging maximized recycling and minimized waste. Tomato processing by-products are abundant in carotenoids, which have several health-promoting properties, and their reintegration into functional food products represents a major interest for scientists and manufacturers. In the present study, carotenoids were recovered from tomato processing by-products based on the principles of green chemistry by using generally recognized as safe (GRAS) solvents, freeze-drying as pretreatment, and ultrasound in the recovery procedure. Spectrophotometric measurements and HPLC were used to identify and quantify total and individual carotenoids from the extracts. The highest values for lycopene (1324.89 µg/g dw) were obtained when ethyl lactate was applied as a solvent, followed by ethyl acetate with slightly smaller differences (1313.54 µg/g dw). The extracts obtained from freeze-dried samples presented significantly lower amounts of lycopene, indicating that carotenoids are highly susceptible to degradation during lyophilization. Flaxseed, grape seed, and hempseed oils were enriched with carotenoids and their rheological measurements showed favorable viscoelastic properties, especially hempseed and flaxseed oil, with viscosity under 50 mPa·s. Considering the results and the economic perspective of carotenoid recovery from tomato processing by-products, ethyl acetate is suitable, sustainable, and environmentally friendly for carotenoid extraction. Full article
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