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Recent Advances in Macromolecules Applied to Pharmaceutical Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Macromolecular Chemistry".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2283

Special Issue Editor


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Guest Editor
Chemistry Department, Murmansk State Technical University, Murmansk, Russia
Interests: macromolecules; biopolymers; proteins; drug-delivery systems; colloid and surface chemistry; rheology; pharmaceutical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Macromolecules are used in technology for all dosage forms: as bases for ointments, suppositories, pills, etc.; as stabilizers; as prolonging components; and as taste-correcting substances. The introduction of new polymers into technology has made it possible to create new dosage forms: multi-layer long-acting tablets, granules impregnated with a solution of high-molecular-weight substances, microcapsules, ophthalmic medicinal films, and dosage forms for children. These areas have now become well established in the realm of multidisciplinary technology and science. The development of polymeric drugs, drug-delivery systems, implant materials, and controlled drug release based on natural and synthetic polymers are rapidly emerging in pharmaceutical fields. The large numbers of applications of macromolecules have required the covalent attachment of polymers to a wide range of substrates, including low-molecular-weight drugs, affinity ligands, proteins, polysaccharides, oligonucleotides, and micro- and nanoparticles.

This Special Issue of Molecules welcomes all contributions from a comprehensive range of expertise in the exciting area of the application of macromolecules in pharmaceutical chemistry. Proposals from industry manufacturing pharmaceutical products based on natural and synthetic polymers are also welcome.

Prof. Dr. Svetlana Deckach
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Macromolecules
  • Pharmaceutical chemistry
  • Polymers
  • Biopolymers
  • Drug-delivery systems
  • Polymeric materials

Published Papers (1 paper)

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Research

14 pages, 2903 KiB  
Article
Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels
by Alla Mirgorodskaya, Rushana Kushnazarova, Rais Pavlov, Farida Valeeva, Oksana Lenina, Kseniya Bushmeleva, Dmitry Kuryashov, Alexandra Vyshtakalyuk, Gulnara Gaynanova, Konstantin Petrov and Lucia Zakharova
Molecules 2022, 27(19), 6447; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27196447 - 30 Sep 2022
Cited by 7 | Viewed by 1766
Abstract
Abietic acid, a naturally occurring fir resin compound, that exhibits anti-inflammatory and wound-healing properties, was formulated into biocompatible emulgels based on stable microemulsions with the addition of a carbamate-containing surfactant and Carbopol® 940 gel. Various microemulsion and emulgel formulations were tested for [...] Read more.
Abietic acid, a naturally occurring fir resin compound, that exhibits anti-inflammatory and wound-healing properties, was formulated into biocompatible emulgels based on stable microemulsions with the addition of a carbamate-containing surfactant and Carbopol® 940 gel. Various microemulsion and emulgel formulations were tested for antioxidant and wound-healing properties. The chemiluminescence method has shown that all compositions containing abietic acid have a high antioxidant activity. Using Strat-M® skin-modelling membrane, it was found out that emulgels significantly prolong the release of abietic acid. On Wistar rats, it was shown that microemulsions and emulgels containing 0.5% wt. of abietic acid promote the rapid healing of an incised wound and twofold tissue reinforcement compared to the untreated group, as documented by tensiometric wound suture-rupture assay. The high healing-efficiency is associated with a combination of antibacterial activity of the formulation components and the anti-inflammatory action of abietic acid. Full article
(This article belongs to the Special Issue Recent Advances in Macromolecules Applied to Pharmaceutical Chemistry)
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