molecules-logo

Journal Browser

Journal Browser

A Theme Issue Honoring Professor Bo Liedberg

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2627

Special Issue Editors


E-Mail Website
Guest Editor
Department of Chemical Engineering, University of California, Davis, CA 95616, USA
Interests: model membranes; membrane-protein interactions; and biophysical characterization
Special Issues, Collections and Topics in MDPI journals
Centre for Biomimetic Sensor Science, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore
Interests: self-assembly; polymer-lipid hybrid vesicle; giant unilamellar vesicles; protein-lipid complexes; biomimetic model; membrane biophysics; cancer cell biology; protein folding; membrane protein; membrane interaction

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to Professor Bo Liedberg on the occasion of his retirement from Nanyang Technological University, Singapore. Spanning the fields of molecular self-assembly, biosensors, optical transduction, membrane biophysics, soft matter, and protein interactions, Professor Liedberg has made multiple pioneering, significant, and lasting contributions during his tenures at the Linkoping University in Sweden and the Nanyang Technological University in Singapore. His scientific leadership in these fields is only matched by his persistent campaigns championing graduate education, global partnerships, and interdisciplinary collaborations.  Contributions in this issue by his scientific colleagues, friends, and collaborators will provide a snapshot of his scientific and professional itinerary and celebrate his accomplishments.

Prof. Dr. Atul N. Parikh
Dr. James Ho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular self-assembly
  • biosensors
  • optical transduction
  • molecular recognition
  • membrane–protein interactions
  • surface plasmon resonance
  • self-assembled monolayers

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

12 pages, 3014 KiB  
Article
Colorimetric Assaying of Exosomal Metabolic Biomarkers
by Evelias Yan, Garima Goyal, Umit Hakan Yildiz, Bernhard O. Boehm and Alagappan Palaniappan
Molecules 2023, 28(4), 1909; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules28041909 - 16 Feb 2023
Cited by 2 | Viewed by 1866
Abstract
Exosomes released into the extracellular matrix have been reported to contain metabolic biomarkers of various diseases. These intraluminal vesicles are typically found in blood, urine, saliva, breast milk, cerebrospinal fluid, semen, amniotic fluid, and ascites. Analysis of exosomal content with specific profiles of [...] Read more.
Exosomes released into the extracellular matrix have been reported to contain metabolic biomarkers of various diseases. These intraluminal vesicles are typically found in blood, urine, saliva, breast milk, cerebrospinal fluid, semen, amniotic fluid, and ascites. Analysis of exosomal content with specific profiles of DNA, microRNA, proteins, and lipids can mirror their cellular origin and physiological state. Therefore, exosomal cargos may reflect the physiological processes at cellular level and can potentially be used as biomarkers. Herein, we report an optical detection method for assaying exosomal biomarkers that supersedes the state-of-the-art time consuming and laborious assays such as ELISA and NTA. The proposed assay monitors the changes in optical properties of poly(3-(4-methyl-3′-thienyloxy) propyltriethylammonium bromide) upon interacting with aptamers/peptide nucleic acids in the presence or absence of target biomarkers. As a proof of concept, this study demonstrates facile assaying of microRNA, DNA, and advanced glycation end products in exosomes isolated from human plasma with detection levels of ~1.2, 0.04, and 0.35 fM/exosome, respectively. Thus, the obtained results illustrate that the proposed methodology is applicable for rapid and facile detection of generic exosomal biomarkers for facilitating diseases diagnosis. Full article
(This article belongs to the Special Issue A Theme Issue Honoring Professor Bo Liedberg)
Show Figures

Figure 1

Back to TopTop