Protein Biosynthesis: From Mechanism to Structure
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 2757
Special Issue Editors
Interests: protein biosynthesis; gene expression regulation; ribosome profiling; antibiotics targeting ribosomes; antibiotic resistance mechanisms
Special Issue Information
Dear Colleagues,
Protein biosynthesis is a fundamental process in every living cell, during which the ribosome and associated factors translate the information encoded in mRNA into polypeptides. The precise control of this process lies at the heart of cellular response to stress and adaptation to the surrounding environment. Although the field of protein biosynthesis is over eighty years old, the regulation of gene expression at the translational level remains an underexplored area. The role of ribosomes in gene expression regulation was neglected for decades. However, the more recent experimental evidence suggests that ribosomes may take the role of regulatory elements in response to changing environmental conditions. Further, in addition to a set of elongation and recycling factors which are conserved and necessary for the functioning of translation initiation, evolution has selected a number of proteins that can help to maintain and preserve translation under stress conditions. Such specialized translation factors help protein biosynthesis machinery to respond rapidly and specifically to, e.g., nutrient deficiency or antibiotic stress. Indeed, translational machinery is one of the major targets for the action of a plethora of antibiotics. However, in many cases, the exact modes of action, physiological responses, and related resistance mechanisms remain vague.
Recent technological advances in next-generation sequencing, single-particle cryo-EM, and cryotomography Cryo-ET methods and many others have opened new avenues and approaches to translation research. In this Special Issue, we would like to welcome discoveries related to this wonderfully broad topic and encompassing all aspects of protein biosynthesis.
Dr. Agata L. Starosta
Dr. Jean-Paul Armache
Guest Editors
Manuscript Submission Information
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Keywords
- Protein biosynthesis
- Translation
- Ribosome
- Gene expression regulation ribosome profiling
- Antibiotics targeting ribosomes
- Ribosome-related antibiotic resistance mechanisms
