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Nanomaterials
Special Issues
New Insights in Toxicity and Cytotoxicity of Nanomaterials
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New Insights in Toxicity and Cytotoxicity of Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 4032

Special Issue Editors

Dr. Maria João Silva

E-Mail Website1 Website2
Guest Editor
1. Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal
2. Centre for Toxicogenomics and Human Health, NOVA Medical School, NOVA University of Lisbon, Lisbon, Portugal
Interests: environmental genotoxicity; nanotoxicology; human genetics; toxicogenomics
Special Issues, Collections and Topics in MDPI journals
Dr. Henriqueta Louro

E-Mail Website1 Website2
Guest Editor
1. Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal
2. Centre for Toxicogenomics and Human Health, NOVA Medical School, NOVA University of Lisbon, Lisbon, Portugal
Interests: nanosafety; human biomonitoring; genetic toxicology; public health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The emerging field of nanoscience has provided new advantageous materials for human use, with applications for innovative nanomaterials (NMs) and diverse consumer products, such as electronics, food and feed, cosmetics or even pharmaceuticals. For innovation to keep pace with safety, new challenges arise for testing nanomaterials, in view of their biological moiety. In fact, the changes in the physicochemical properties of the NMs once in contact with cellular components, such as superficial charge or corona formation, may hamper the interpretation of current toxicity tests, requiring the modification of procedures, new methods and a novel outlook on risk assessment.

This Special Issue aims to include research studies which focus on the potential adverse effects of nanomaterials and nanoparticles and articles which discuss the development of safer and sustainable materials which can provide major societal benefits.

We invite authors from the research community to submit their work on nanosafety, including in vitro, in vivo or human biomonitoring studies, as well as literature reviews, especially with a focus on new alternative methodologies that enhance the field of nanosafety and contribute to the understanding of the mode of action or adverse outcome pathways associated with nanomaterials and nanoparticles.

Dr. Maria João Silva
Dr. Henriqueta Louro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanoparticles
  • nanosafety
  • toxicity
  • cytotoxicity
  • genotoxicity
  • epigenetics
  • effect biomarkers
  • human biomonitoring
  • adverse outcome pathways

Published Papers (2 papers)

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Review

45 pages, 1771 KiB  
Review
Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure
by Nádia Vital, Célia Ventura, Michel Kranendonk, Maria João Silva and Henriqueta Louro
Nanomaterials 2022, 12(19), 3375; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12193375 - 27 Sep 2022
Cited by 2 | Viewed by 1683
Abstract
Cellulose nanomaterials (CNMs) have emerged recently as an important group of sustainable bio-based nanomaterials (NMs) with potential applications in multiple sectors, including the food, food packaging, and biomedical fields. The widening of these applications leads to increased human oral exposure to these NMs [...] Read more.
Cellulose nanomaterials (CNMs) have emerged recently as an important group of sustainable bio-based nanomaterials (NMs) with potential applications in multiple sectors, including the food, food packaging, and biomedical fields. The widening of these applications leads to increased human oral exposure to these NMs and, potentially, to adverse health outcomes. Presently, the potential hazards regarding oral exposure to CNMs are insufficiently characterised. There is a need to understand and manage the potential adverse effects that might result from the ingestion of CNMs before products using CNMs reach commercialisation. This work reviews the potential applications of CNMs in the food and biomedical sectors along with the existing toxicological in vitro and in vivo studies, while also identifying current knowledge gaps. Relevant considerations when performing toxicological studies following oral exposure to CNMs are highlighted. An increasing number of studies have been published in the last years, overall showing that ingested CNMs are not toxic to the gastrointestinal tract (GIT), suggestive of the biocompatibility of the majority of the tested CNMs. However, in vitro and in vivo genotoxicity studies, as well as long-term carcinogenic or reproductive toxicity studies, are not yet available. These studies are needed to support a wider use of CNMs in applications that can lead to human oral ingestion, thereby promoting a safe and sustainable-by-design approach. Full article
(This article belongs to the Special Issue New Insights in Toxicity and Cytotoxicity of Nanomaterials)
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32 pages, 3047 KiB  
Review
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review
by Dora Rolo, Ricardo Assunção, Célia Ventura, Paula Alvito, Lídia Gonçalves, Carla Martins, Ana Bettencourt, Peter Jordan, Nádia Vital, Joana Pereira, Fátima Pinto, Paulo Matos, Maria João Silva and Henriqueta Louro
Nanomaterials 2022, 12(19), 3275; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12193275 - 21 Sep 2022
Cited by 9 | Viewed by 3496
Abstract
Titanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome [...] Read more.
Titanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integrative analysis of the published data on cellular and molecular mechanisms triggered after the ingestion of TiO2-NPs, proposing plausible AOPs that may drive policy decisions. A systematic review according to Prisma Methodology was performed in three databases of peer-reviewed literature: Pubmed, Scopus, and Web of Science. A total of 787 records were identified, screened in title/abstract, being 185 used for data extraction. The main endpoints identified were oxidative stress, cytotoxicity/apoptosis/cell death, inflammation, cellular and systemic uptake, genotoxicity, and carcinogenicity. From the results, AOPs were proposed where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. The recent transgenerational studies also point to concerns with regard to population effects. Overall, the findings further support a limitation of the use of TiO2-NPs in food, announced by the European Food Safety Authority (EFSA). Full article
(This article belongs to the Special Issue New Insights in Toxicity and Cytotoxicity of Nanomaterials)
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