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Advanced Nanomaterials in Biomedical Application (2nd Edition)

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A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 10 June 2024 | Viewed by 5397

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Special Issue Editors

Prof. Dr. Goran Kaluđerović

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Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Strasse 2, 06217 Merseburg, Germany
Interests: antitumor drugs; molecular oncology; drug targeting; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Nebojša Pantelić

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Department of Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, Belgrade, Serbia
Interests: inorganic chemistry; bioinorganic chemistry; nanomaterials; metal-based complexes; anticancer drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, many efforts have been focused on the discovery of various types of nanomaterials. In addition to basic research on the synthesis of nanoconstructs, the goal of such research has been to identify nanoparticles applicable in various fields, including technology (catalysis), medicine (drug delivery), etc. As a result of the increasing number of potential applications, the demand for novel nanomaterials is growing rapidly.

This Special Issue on “Advanced Nanomaterials in Biomedical Application (2nd Edition)” aims to showcase the most recent advances in nanomaterials’ synthesis and characterization, as well as their technological applications. This Special Issue welcomes original research articles and reviews. Research areas may include all types of nanomaterials used in the development of medical applications, including, but not limited to, therapeutics (anticancer, antibacterial, toxicology, etc.), diagnostics (imaging, etc.), and nanodevices.

We look forward to receiving your contributions.

Prof. Dr. Goran Kaluđerović
Prof. Dr. Nebojša Pantelić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

biomedical application
drug delivery
therapeutics
anticancer
antibacterial
toxicology
diagnostics
imaging

Published Papers (4 papers)

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Research

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15 pages, 5020 KiB

Open AccessArticle

Alginate Microsponges as a Scaffold for Delivery of a Therapeutic Peptide against Rheumatoid Arthritis

by Daniela Ariaudo, Francesca Cavalieri, Antonio Rinaldi, Ana Aguilera, Matilde Lopez, Hilda Garay Perez, Ariel Felipe, Maria del Carmen Dominguez, Odalys Ruiz, Gillian Martinez and Mariano Venanzi

Nanomaterials 2023, 13(19), 2709; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13192709 - 05 Oct 2023

Cited by 1 | Viewed by 1142

Abstract

The quest for biocompatible drug-delivery devices that could be able to open new administration routes is at the frontier of biomedical research. In this contribution, porous polysaccharide-based microsponges based on crosslinked alginate polymers were developed and characterized by optical spectroscopy and nanoscopic microscopy techniques. We show that macropores with a size distribution ranging from 50 to 120 nm enabled efficient loading and delivery of a therapeutic peptide (CIGB814), presently under a phase 3 clinical trial for the treatment of rheumatoid arthritis. Alginate microsponges showed 80% loading capacity and sustained peptide release over a few hours through a diffusional mechanism favored by partial erosion of the polymer scaffold. The edible and biocompatible nature of alginate polymers open promising perspectives for developing a new generation of polysaccharide-based carriers for the controlled delivery of peptide drugs, exploiting alternative routes with respect to intravenous administration. Full article

(This article belongs to the Special Issue Advanced Nanomaterials in Biomedical Application (2nd Edition))

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14 pages, 4036 KiB

Open AccessArticle

A Sensitive Micro Conductometric Ethanol Sensor Based on an Alcohol Dehydrogenase-Gold Nanoparticle Chitosan Composite

by Anis Madaci, Patcharapan Suwannin, Guy Raffin, Marie Hangouet, Marie Martin, Hana Ferkous, Abderrazak Bouzid, Joan Bausells, Abdelhamid Elaissari, Abdelhamid Errachid and Nicole Jaffrezic-Renault

Nanomaterials 2023, 13(16), 2316; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13162316 - 12 Aug 2023

Viewed by 1033

Abstract

In this paper, a microconductometric sensor has been designed, based on a chitosan composite including alcohol dehydrogenase—and its cofactor—and gold nanoparticles, and was calibrated by differential measurements in the headspace of aqueous solutions of ethanol. The role of gold nanoparticles (GNPs) was crucial in improving the analytical performance of the ethanol sensor in terms of response time, sensitivity, selectivity, and reproducibility. The response time was reduced to 10 s, compared to 21 s without GNPs. The sensitivity was 416 µS/cm (v/v%)⁻¹ which is 11.3 times higher than without GNPs. The selectivity factor versus methanol was 8.3, three times higher than without GNPs. The relative standard deviation (RSD) obtained with the same sensor was 2%, whereas it was found to be 12% without GNPs. When the air from the operator’s mouth was analyzed just after rinsing with an antiseptic mouthwash, the ethanol content was very high (3.5 v/v%). The background level was reached only after rinsing with water. Full article

(This article belongs to the Special Issue Advanced Nanomaterials in Biomedical Application (2nd Edition))

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16 pages, 2832 KiB

Open AccessArticle

Factors Influencing the Repeated Transient Optical Droplet Vaporization Threshold and Lifetimes of Phase Change, Perfluorocarbon Nanodroplets

by Andrew X. Zhao, Yiying I. Zhu, Euisuk Chung, Jeehyun Lee, Samuel Morais, Heechul Yoon and Stanislav Emelianov

Nanomaterials 2023, 13(15), 2238; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13152238 - 02 Aug 2023

Cited by 1 | Viewed by 1135

Abstract

Perfluorocarbon nanodroplets (PFCnDs) are sub-micrometer emulsions composed of a surfactant-encased perfluorocarbon (PFC) liquid and can be formulated to transiently vaporize through optical stimulation. However, the factors governing repeated optical droplet vaporization (ODV) have not been investigated. In this study, we employ high-frame-rate ultrasound (US) to characterize the ODV thresholds of various formulations and imaging parameters and identify those that exhibit low vaporization thresholds and repeatable vaporization. We observe a phenomenon termed “preconditioning”, where initial laser pulses generate reduced US contrast that appears linked with an increase in nanodroplet size. Variation in laser pulse repetition frequency is found not to change the vaporization threshold, suggesting that “preconditioning” is not related to residual heat. Surfactants (bovine serum albumin, lipids, and zonyl) impact the vaporization threshold and imaging lifetime, with lipid shells demonstrating the best performance with relatively low thresholds (21.6 ± 3.7 mJ/cm²) and long lifetimes (t_1/2 = 104 ± 21.5 pulses at 75 mJ/cm²). Physiological stiffness does not affect the ODV threshold and may enhance nanodroplet stability. Furthermore, PFC critical temperatures are found to correlate with vaporization thresholds. These observations enhance our understanding of ODV behavior and pave the way for improved nanodroplet performance in biomedical applications. Full article

(This article belongs to the Special Issue Advanced Nanomaterials in Biomedical Application (2nd Edition))

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Review

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24 pages, 1146 KiB

Open AccessReview

Silicon-Based Avalanche Photodiodes: Advancements and Applications in Medical Imaging

by Kirill A. Lozovoy, Rahaf M. H. Douhan, Vladimir V. Dirko, Hazem Deeb, Kristina I. Khomyakova, Olzhas I. Kukenov, Arseniy S. Sokolov, Nataliya Yu. Akimenko and Andrey P. Kokhanenko

Nanomaterials 2023, 13(23), 3078; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13233078 - 04 Dec 2023

Cited by 1 | Viewed by 1552

Abstract

Avalanche photodiodes have emerged as a promising technology with significant potential for various medical applications. This article presents an overview of the advancements and applications of avalanche photodiodes in the field of medical imaging. Avalanche photodiodes offer distinct advantages over traditional photodetectors, including a higher responsivity, faster response times, and superior signal-to-noise ratios. These characteristics make avalanche photodiodes particularly suitable for medical-imaging modalities that require a high detection efficiency, excellent timing resolution, and enhanced spatial resolution. This review explores the key features of avalanche photodiodes, discusses their applications in medical-imaging techniques, and highlights the challenges and future prospects in utilizing avalanche photodiodes for medical purposes. Special attention is paid to the recent progress in silicon-compatible avalanche photodiodes. Full article

(This article belongs to the Special Issue Advanced Nanomaterials in Biomedical Application (2nd Edition))

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