Research and Application of Molecularly Imprinted Polymers

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 847

Special Issue Editor


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Guest Editor
School of Marine Sciences, Ningbo University, 818 Fenghua Road, Ningbo 315211, China
Interests: molecularly imrpited polymers; fluorescence probe; application; fabrication

Special Issue Information

Dear Colleagues,

Molecularly imprinted polymers (MIPs) are highly cross-linked porous-rich polymers with specific recognition sites complementary in shape, size and functional groups to the target molecule and capable of mimicking receptors and antibodies. Currently, molecularly imprinting technology has been rapidly developed and the obtained MIPs, with excellent properties of easy synthesis, high selectivity, biocompatibility, chemo-thermal stability and combustibility, are relevant to many fields. Meanwhile, the rapid development of preparation methods for MIPs has also further promoted their exploration in numerous fields.

The Special Issue focuses on the most recent advances in “Research and Application of Molecularly Imprinted Polymers”, and promotes and contributes to the development of synthesis methods in order to obtain unique physical-chemical properties, and applications in environment, food safety, sample pretreatment, drug delivery, simulated enzyme catalysis, contaminant removal, and sensor technology, etc. The topics include, but are not limited to, the following:

  • Advanced molecular imprinting technology with excellent recognition performance;
  • Integration of MIPs with advanced nanomaterials and their applications;
  • The application of MIPs in environment, food safety, and biomedical applications;
  • Molecularly imprinted systems for biorecognition and biosensing. 

Prof. Dr. Xi-Zhi Shi
Guest Editor

Manuscript Submission Information

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Keywords

  • MIPs
  • application
  • recognition

Published Papers (1 paper)

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Research

13 pages, 1244 KiB  
Article
Selective Extraction of Diazepam and Its Metabolites from Urine Samples by a Molecularly Imprinted Solid-Phase Extraction (MISPE) Method
by Ana María Gil Tejedor, Juan Carlos Bravo Yagüe, Gema Paniagua González, Rosa María Garcinuño Martínez and Pilar Fernández Hernando
Polymers 2024, 16(5), 635; https://0-doi-org.brum.beds.ac.uk/10.3390/polym16050635 - 27 Feb 2024
Viewed by 583
Abstract
In this research, a molecularly imprinted polymer (MIP) was synthesized by precipitation polymerization using oxazepam (OZ) as a template molecule and was subsequently applied as a selective sorbent for the extraction of diazepam (DZP) and its metabolites in urine samples using an SPE [...] Read more.
In this research, a molecularly imprinted polymer (MIP) was synthesized by precipitation polymerization using oxazepam (OZ) as a template molecule and was subsequently applied as a selective sorbent for the extraction of diazepam (DZP) and its metabolites in urine samples using an SPE cartridge. OZ, temazepam (TZ), nordiazepam (NZ) and DZP were analyzed in the final extracts by high-performance liquid chromatography with diode array detection (HPLC-DAD). The SPE extraction steps were optimized, and the evaluation of an imprinting factor was carried out. The selectivity of the method for OZ versus structurally related benzodiazepines (BZDs), such as bromazepam (BRZ), tetrazepam (TTZ) and halazepam (HZ), was investigated. Under the optimum conditions, the proposed methodology provided good linearity in the range of 10–1500 ng/mL, with limit of detection values between 13.5 and 21.1 ng/mL and recovery levels for DZP and its metabolites from 89.0 to 93.9% (RSD ≤ 8%) at a concentration level of 1000 ng/mL. The proposed method exhibited good selectivity, precision and accuracy and was applied to the analysis of urine samples from a real case of DZP intake. Full article
(This article belongs to the Special Issue Research and Application of Molecularly Imprinted Polymers)
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