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Polymers
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Intelligent Self-Assembled Polymer for Targeted Cancer Treatment
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Intelligent Self-Assembled Polymer for Targeted Cancer Treatment

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 3977

Special Issue Editor

Dr. Hisham A. Alhadlaq

E-Mail Website
Guest Editor
Department of Physics and Astronomy and King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
Interests: nanomedicine; nanoparticle toxicity; cancer biology; targeted therapy; cancer cell

Special Issue Information

Dear Colleagues,

This Special Issue on Intelligent Self-Assembled Polymers for Targeted Cancer Treatment is specifically devoted to the solicitation of high-quality original articles, short communications, and comprehensive reviews on recent and front-line developments in this interdisciplinary and multidisciplinary field. In the last decade, polymer science and “smart” self-assembled structure technology have been driven by recent advancements in biomedical applications in diagnosis and therapy. A large number of smart polymers and biopolymers, which are characterized with important biodegradability features, have been recently developed for biomedical applications. Such new biomedical applications are advancing research breakthroughs for the treatment of chronic diseases, promoting better treatment options and disease management.

Polymeric materials have recently attracted significant interest from researchers for targeted delivery and biomedical applications, possibly due to their many advantages over other traditional materials, including their inexpensive and easy synthesis, suitability for work in aqueous solutions, and possibility to facilitate large responses to weak stimuli. Chemotherapy still has huge downsides such as low specificity for tumor cells, high toxicity at local areas, and a lack of aqueous solubility. New areas, such as polymer-based nanomedicine and smart self-assembled materials, are promising for improving targeted delivery with fewer disadvantages than traditional drug delivery. This is encouraging for cancer-treatment options, with the possibility of sparing normal cells and reducing side effects.

Dr. Hisham A. Alhadlaq
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer-based materials
  • targeted therapy
  • nanomedicine
  • polymeric carriers
  • polymeric nanoparticle
  • bio-based polymeric materials
  • biodegradable polymers
  • self-assembly
  • toxicity
  • anticancer drugs
  • cancer therapy

Published Papers (2 papers)

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Research

16 pages, 6678 KiB  
Article
One-Pot Synthesis of SnO2-rGO Nanocomposite for Enhanced Photocatalytic and Anticancer Activity
by ZabnAllah M. Alaizeri, Hisham A. Alhadlaq, Saad Aldawood, Mohd Javed Akhtar and Maqusood Ahamed
Polymers 2022, 14(10), 2036; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14102036 - 16 May 2022
Cited by 13 | Viewed by 2234
Abstract
Metal oxide and graphene derivative-based nanocomposites (NCs) are attractive to the fields of environmental remediation, optics, and cancer therapy owing to their remarkable physicochemical characteristics. There is limited information on the environmental and biomedical applications of tin oxide-reduced graphene oxide nanocomposites (SnO2 [...] Read more.
Metal oxide and graphene derivative-based nanocomposites (NCs) are attractive to the fields of environmental remediation, optics, and cancer therapy owing to their remarkable physicochemical characteristics. There is limited information on the environmental and biomedical applications of tin oxide-reduced graphene oxide nanocomposites (SnO2-rGO NCs). The goal of this work was to explore the photocatalytic activity and anticancer efficacy of SnO2-rGO NCs. Pure SnO2 NPs and SnO2-rGO NCs were prepared using the one-pot hydrothermal method. X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), UV–Vis spectrometry, photoluminescence (PL), and Raman scattering microscopy were applied to characterize the synthesized samples. The crystallite size of the SnO2 NPs slightly increased after rGO doping. TEM and SEM images show that the SnO2 NPs were tightly anchored onto the rGO sheets. The XPS and EDX data confirmed the chemical state and elemental composition of the SnO2-rGO NCs. Optical data suggest that the bandgap energy of the SnO2-rGO NCs was slightly lower than for the pure SnO2 NPs. In comparison to pure SnO2 NPs, the intensity of the PL spectra of the SnO2-rGO NCs was lower, indicating the decrement of the recombination rate of the surfaces charges (e−/h+) after rGO doping. Hence, the degradation efficiency of methylene blue (MB) dye by SnO2-rGO NCs (93%) was almost 2-fold higher than for pure SnO2 NPs (54%). The anticancer efficacy of SnO2-rGO NCs was also almost 1.5-fold higher against human liver cancer (HepG2) and human lung cancer (A549) cells compared to the SnO2 NPs. This study suggests a unique method to improve the photocatalytic activity and anticancer efficacy of SnO2 NPs by fusion with graphene derivatives. Full article
(This article belongs to the Special Issue Intelligent Self-Assembled Polymer for Targeted Cancer Treatment)
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16 pages, 3706 KiB  
Article
Reactive Oxygen Species-Responsive Miktoarm Amphiphile for Triggered Intracellular Release of Anti-Cancer Therapeutics
by Hyun-Chul Kim, Eunjoo Kim, Se Guen Lee, Sung Jun Lee, Sang Won Jeong, Young Jae Lee, Mi Kyung Kwon, Seong-Kyoon Choi, Jun Seong Hwang and Eunsook Choi
Polymers 2021, 13(24), 4418; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13244418 - 16 Dec 2021
Cited by 1 | Viewed by 1975
Abstract
Reactive oxygen species (ROS)-responsive nanocarriers have received considerable research attention as putative cancer treatments because their tumor cell targets have high ROS levels. Here, we synthesized a miktoarm amphiphile of dithioketal-linked ditocopheryl polyethylene glycol (DTTP) by introducing ROS-cleavable thioketal groups as linkers between [...] Read more.
Reactive oxygen species (ROS)-responsive nanocarriers have received considerable research attention as putative cancer treatments because their tumor cell targets have high ROS levels. Here, we synthesized a miktoarm amphiphile of dithioketal-linked ditocopheryl polyethylene glycol (DTTP) by introducing ROS-cleavable thioketal groups as linkers between the hydrophilic and hydrophobic moieties. We used the product as a carrier for the controlled release of doxorubicin (DOX). DTTP has a critical micelle concentration (CMC) as low as 1.55 μg/mL (4.18 × 10−4 mM), encapsulation efficiency as high as 43.6 ± 0.23% and 14.6 nm particle size. The DTTP micelles were very responsive to ROS and released their DOX loads in a controlled manner. The tocopheryl derivates linked to DTTP generated ROS and added to the intracellular ROS in MCF-7 cancer cells but not in HEK-293 normal cells. In vitro cytotoxicity assays demonstrated that DOX-encapsulated DTTP micelles displayed strong antitumor activity but only slightly increased apoptosis in normal cells. This ROS-triggered, self-accelerating drug release device has high therapeutic efficacy and could be a practical new strategy for the clinical application of ROS-responsive drug delivery systems. Full article
(This article belongs to the Special Issue Intelligent Self-Assembled Polymer for Targeted Cancer Treatment)
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