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Polymers
Special Issues
Stimuli-Responsive Polymeric Nanoparticles
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Stimuli-Responsive Polymeric Nanoparticles

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 1898

Special Issue Editor

Dr. Arn Mignon

E-Mail Website1 Website2
Guest Editor
Smart Polymeric Biomaterials - Biomaterials and Tissue Engineering @ Campus Group T Leuven, KU Leuven, Andreas Vesaliusstraat 13, 3000 Leuven, Belgium
Interests: smart polymers; polysaccharides; biomaterials; pH-responsive systems; temperature- responsive systems; enzyme-responsive systems; toxin-responsive systems; superabsorbent polymers; hydrogels; self-healing; wound healing; tendon repair; dental repair; cardiovascular applications; diabetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoparticles are used for different applications. Nowadays, they are especially useful for drug release, but have more potential. They also are very challenging to make and to keep stable over longer periods. There are multiple nanoparticle types such as micelles, polymersomes, liposomes, proteinosomes, etc. It is challenging to make them responsive to stimuli so that they release their contents or break open. These triggers include changing the pH, temperature, enzyme, or other environmental factors.

This Special Issue will explore the design, synthesis, processing, characterization, and applications of stimuli-responsive polymeric nanoparticles. Considering your prominent contributions to this field, I invite you to submit an article to this Special Issue. Full research papers, communications, and review articles are encouraged. The aim is to collate a collection of comprehensive articles from leading experts and up-to-date research from notable groups in the community.

Dr. Arn Mignon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart polymers
  • polymersomes
  • micelles
  • nanoparticles

Published Papers (1 paper)

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Research

17 pages, 3715 KiB  
Article
Synthesis of Multifunctional Polymersomes Prepared by Polymerization-Induced Self-Assembly
by Hien Phan, Robert Cavanagh, Philippa Jacob, Damien Destouches, Francis Vacherot, Benedetta Brugnoli, Steve Howdle, Vincenzo Taresco and Benoit Couturaud
Polymers 2023, 15(14), 3070; https://0-doi-org.brum.beds.ac.uk/10.3390/polym15143070 - 17 Jul 2023
Cited by 3 | Viewed by 1732
Abstract
Polymersomes are an exciting modality for drug delivery due to their structural similarity to biological cells and their ability to encapsulate both hydrophilic and hydrophobic drugs. In this regard, the current work aimed to develop multifunctional polymersomes, integrating dye (with hydrophobic Nile red [...] Read more.
Polymersomes are an exciting modality for drug delivery due to their structural similarity to biological cells and their ability to encapsulate both hydrophilic and hydrophobic drugs. In this regard, the current work aimed to develop multifunctional polymersomes, integrating dye (with hydrophobic Nile red and hydrophilic sulfo-cyanine5-NHS ester as model drugs) encapsulation, stimulus responsiveness, and surface-ligand modifications. Polymersomes constituting poly(N-2-hydroxypropylmethacrylamide)-b-poly(N-(2-(methylthio)ethyl)acrylamide) (PHPMAm-b-PMTEAM) are prepared by aqueous dispersion RAFT-mediated polymerization-induced self-assembly (PISA). The hydrophilic block lengths have an effect on the obtained morphologies, with short chain P(HPMAm)16 affording spheres and long chain P(HPMAm)43 yielding vesicles. This further induces different responses to H2O2, with spheres fragmenting and vesicles aggregating. Folic acid (FA) is successfully conjugated to the P(HPMAm)43, which self-assembles into FA-functionalized P(HPMAm)43-b-P(MTEAM)300 polymersomes. The FA-functionalized P(HPMAm)43-b-P(MTEAM)300 polymersomes entrap both hydrophobic Nile red (NR) and hydrophilic Cy5 dye. The NR-loaded FA-linked polymersomes exhibit a controlled release of the encapsulated NR dye when exposed to 10 mM H2O2. All the polymersomes formed are stable in human plasma and well-tolerated in MCF-7 breast cancer cells. These preliminary results demonstrate that, with simple and scalable chemistry, PISA offers access to different shapes and opens up the possibility of the one-pot synthesis of multicompartmental and responsive polymersomes. Full article
(This article belongs to the Special Issue Stimuli-Responsive Polymeric Nanoparticles)
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