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Polymers
Special Issues
Advanced Biopolymers for Disease Treatment
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Advanced Biopolymers for Disease Treatment

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (25 May 2023) | Viewed by 5150

Special Issue Editors

Dr. Yu-Chun Chen

E-Mail Website
Guest Editor
Department of Chemical Engineering, National United University, Miaoli 360023, Taiwan
Interests: tissue engineering; biopolymer; hydrogel; cell therapy; regeneration medicine
Dr. Wen-Yu Su

E-Mail Website
Guest Editor
Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan
Interests: tissue engineering; regeneration medicine; enviromental-sensitive hydrogel; bioceramics

Special Issue Information

Dear Colleagues, 

Thanks for the contribution of Prof. Langer and Vacanti, the research related to advanced biopolymer for tissue regeneration has grown up rapidly since 1988. The concept of tissue engineering led biopolymer to another new era, scientist using various natural biopolymer such as hyaluronic acid, chitosan, gelatin, collagen and peptides as raw material for membrane, scaffold or hydrogel preparation. Combination with several techniques such as solvent casting, emulsification freeze-drying, particulate leaching, electrospinning, 3D printing, and even self-assembled techniques for better scaffold or hydrogel production. In order to mimic the physiological environment, specific cytokines, growth factors, and chemicals may be added or even crosslinked to material for functional biopolymer development. Besides, some research focus on physical environment mimics, they incubated the scaffold or hydrogel under specific physical stimulation before implantation. Cell is one of the most key factors in tissue engineering product. Usually, scientist prefer to use primary cell rather than cell line, since the response of primary cell is closer to in vivo situation. Considering the regeneration ability and accessibility, stem cell is the most popular cell type incorporated into the scaffold or hydrogel. Recently, some research even try to use particles produced by stem cell, exosome, combined with advanced biopolymers for disease treatment. Biocompatibility and treatment effect are two key point for in vitro and in vivo evaluation.

The aim of this Special Issue is to collect the latest developments in advanced biopolymers for disease treatment. Studying the relationships among cell, biopolymers and regenerated tissue are also welcome. This Special Issue covers full research papers, communications and up-to-date reviews.

Dr. Yu-Chun Chen 
Dr. Wen-Yu Su 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • enviromental-sensitive biopolymer
  • functional biopolymer
  • natural advanced biopolymer
  • biocompatibility
  • adult/embryonic stem cell
  • clinical application

Published Papers (2 papers)

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Research

11 pages, 2505 KiB  
Article
Evaluating Pull-Out Strength of Barbed Suture In Vitro by Using Porcine Tissue and Polydimethylsiloxane (PDMS)
by Wei Hong, I-Cheng Chen, Chen-Ying Su, Cherng-Kang Perng, Hsu Ma and Hsu-Wei Fang
Polymers 2022, 14(11), 2170; https://doi.org/10.3390/polym14112170 - 27 May 2022
Viewed by 2509
Abstract
Using barbed thread lifting for facial rejuvenation has become popular these days due to its minimally invasive procedures with reduced complications. However, only limited studies regarding its mechanical properties for face suspension were published. The aim of this study was to evaluate suture-holding [...] Read more.
Using barbed thread lifting for facial rejuvenation has become popular these days due to its minimally invasive procedures with reduced complications. However, only limited studies regarding its mechanical properties for face suspension were published. The aim of this study was to evaluate suture-holding ability regarding its facelift property, and different specimens were tested in order to establish an in vitro model. Fresh porcine tissue and the synthetic material polydimethylsiloxane (PDMS) were selected to simulate human skin for evaluating barbed suture pull-out strength by the universal material testing machine. The results showed that the pull-out strength of barbs between different porcine tissues varied without consistency. By contrast, PDMS (30:1) showed more consistent pull-out strength in each testing, and the average maximum load force was close to porcine tissue. Furthermore, after submerging barbed sutures in PBS for 0 days (T0), 7 days (T7) and 14 days (T14), a trend of decreased average maximum load force, displacement and force of 1.5 mm/2 mm/3 mm displacement could be detected by in vitro testing with PDMS (30:1). These results provide support for using PDMS (30:1) to evaluate suture pull-out strength and holding/lifting capacities in vitro to obtain consistent and objective information for evaluating substantial equivalence of devices. The established in vitro method could be used for the future development of barbed thread lifting technology. Full article
(This article belongs to the Special Issue Advanced Biopolymers for Disease Treatment)
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19 pages, 14996 KiB  
Article
Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model
by Yu-Chun Chen, Hsiu-Jung Liao, Yuan-Ming Hsu, Yi-Shan Shen and Chih-Hung Chang
Polymers 2022, 14(7), 1474; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14071474 - 05 Apr 2022
Cited by 1 | Viewed by 1975
Abstract
Due to the limitation in the current treatment modalities, such as secondary surgery in ACI and fibrocartilage formation in microfracture surgery, various scaffolds or hydrogels have been developed for cartilage regeneration. In the present study, we used sodium periodate to oxidize methylcellulose and [...] Read more.
Due to the limitation in the current treatment modalities, such as secondary surgery in ACI and fibrocartilage formation in microfracture surgery, various scaffolds or hydrogels have been developed for cartilage regeneration. In the present study, we used sodium periodate to oxidize methylcellulose and formed dialdehyde methylcellulose (DAC) after dialysis and freeze-drying process, DAC was further mixed with succinyl-chitosan (SUC) to form an DAC-SUC in situ forming hydrogel. The hydrogel is a stiffness, elastic-like and porous hydrogel according to the observation of SEM and rheological analysis. DAC-SUC13 hydrogel possess well cell-compatibility as well as biodegradability. Most bone marrow mesenchymal stem cells (BM-pMSCs) were alive in the hydrogel and possess chondrogenesis potential. According to the results of animal study, we found DAC-SUC13 hydrogel can function as a stem cell carrier to promote glycosaminoglycans and type II collagen synthesis in the osteochondral defects of porcine knee. These findings suggested that DAC-SUC13 hydrogel combined with stem cell is a potential treatment for cartilage defects repair in the future. Full article
(This article belongs to the Special Issue Advanced Biopolymers for Disease Treatment)
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