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Polymers
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Multifunctional Natural-Based Polymers for Tissue Engineering & Regenerative Medicine
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Multifunctional Natural-Based Polymers for Tissue Engineering & Regenerative Medicine

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (5 August 2022) | Viewed by 15878

Special Issue Editors

Prof. Dr. Mh Busra Fauzi

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Guest Editor
Centre for Tissue Engineering and Regenerative Medicine (CTERM), Faculty of Medicine, 12th Floor Clinical Block, UKM Medical Centre, Jalan Yaacob Latiff, Cheras 56000, Kuala Lumpur, Malaysia
Interests: biomaterials; drug delivery system; skin wound healing; tissue engineering and regenerative medicine; cell delivery system; multifunctional smart materials; acellular tissue substitute; nanomaterials technology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yasuhiko Tabata

E-Mail Website
Guest Editor
Laboratory of Biomaterials, Department of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Interests: biomaterials; bioabsorbable or non-absorbable materials; regenerative medicine; tissue engineering; cell transplantation therapy; cell research; drug discovery research; drug delivery system (DDS); medical engineering; stem cell engineering
Dr. Ebrahim Mahmoudi

E-Mail Website
Guest Editor
Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi 43600, Malaysia
Interests: functional membrane; natural additive; nanocomposites; photocatalytic degradation; multifunctional adsorbents; cellulose; graphene; chitosan; surface modification; wastewater treatment; molecular imprinting technology

Special Issue Information

Dear Colleagues,

Biomaterial has been established as one major component of regenerative medicine for various biomedical applications and clinical settings. It has emerged as an acellular or cell-based treatment via single or multifunctionalised approaches integrated with biomaterials, either natural or hybrid polymers. The potential applications include tissue engineering, biomolecules/drug delivery, cell delivery, biosensors, and 3D in vitro model development for drugs/natural herbs, etc., as well as toxicity testing. The successful development of a biomaterial will consider the initial 3D design and a selection of suitable formulation and fabrication techniques, followed by physicochemical and mechanical properties to offer an initial perspective for an ideal bioscaffold. Biological interaction using the closest cell type provides information regarding the functionality of fabricated biomaterials for future applications and related immune cells presenting host responses. The abovementioned accurate characterisation parameters allow precise and extensive prediction of selected biomaterials prior to in vivo efficiency testing. Additionally, the biological/molecular pathway determination could present early functionalisation towards the host microenvironment. In vivo safety and efficacy using small or larger animal models can provide beneficial information and big data for specific designed biomaterials of particular applications considering future personalised/precision medicine strategies. 

This Special Issue welcomes any related original research and reviews primarily focusing on natural-based or hybrid polymer biomaterials scrutinising multifunctional-based approaches including three-dimensional design modification, surface morphology, biomaterial compositions, accentuating acellular or cell-based delivery systems, and tissue repair technologies. The aim is to escalate current research on 3D design biscaffolds, fabrication technologies, toxicity, in vitro evaluation on the cell–biomaterials interaction of multifunctionalised polymers and efficiency studies via preclinical models or any related host microenvironments, ensuring their capability to support tissue regeneration. 

Prof. Dr. Mh Busra Fauzi
Prof. Dr. Yasuhiko Tabata
Dr. Ebrahim Mahmoudi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • polymers
  • wound healing
  • tissue engineering
  • regenerative medicine
  • nanotechnology
  • cellular-biomaterials interaction
  • delivery system

Published Papers (4 papers)

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Research

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11 pages, 1713 KiB  
Article
Effect of Hyaluronic Acid on the Differentiation of Mesenchymal Stem Cells into Mature Type II Pneumocytes
by Francesca Della Sala, Mario di Gennaro, Gianluca Lista, Francesco Messina, Luigi Ambrosio and Assunta Borzacchiello
Polymers 2021, 13(17), 2928; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13172928 - 30 Aug 2021
Cited by 17 | Viewed by 2254
Abstract
Hyaluronic acid (HA) is an essential component of the extracellular matrix (ECM) of the healthy lung, playing an important role in the structure of the alveolar surface stabilizing the surfactant proteins. Alveolar type II (ATII) cells are the fundamental element of the alveolus, [...] Read more.
Hyaluronic acid (HA) is an essential component of the extracellular matrix (ECM) of the healthy lung, playing an important role in the structure of the alveolar surface stabilizing the surfactant proteins. Alveolar type II (ATII) cells are the fundamental element of the alveolus, specializing in surfactant production. ATII cells represent the main target of lung external lesion and a cornerstone in the repair process of pulmonary damage. In this context, knowledge of the factors influencing mesenchymal stem cell (MSC) differentiation in ATII cells is pivotal in fulfilling therapeutic strategies based on MSCs in lung regenerative medicine. To achieve this goal, the role of HA in promoting the differentiation of MSCs in mature Type II pneumocytes capable of secreting pulmonary surfactant was evaluated. Results demonstrated that HA, at a specific molecular weight can greatly increase the expression of lung surfactant protein, indicating the ability of HA to influence MSC differentiation in ATII cells. Full article
(This article belongs to the Special Issue Multifunctional Natural-Based Polymers for Tissue Engineering & Regenerative Medicine)
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Review

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13 pages, 2566 KiB  
Review
Silicon-Based Scaffold for Wound Healing Skin Regeneration Applications: A Concise Review
by Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop and Mh Busra Fauzi
Polymers 2022, 14(19), 4219; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14194219 - 08 Oct 2022
Cited by 5 | Viewed by 3205
Abstract
Silicon has made its breakthrough in various industries, including clinical and biomedical applications. Silicon-based biomaterials that were fabricated into various types of scaffolds may attract interest due to their highly favorable properties covering their excellent biocompatibility, high surface area, mechanical strength, and selectivity [...] Read more.
Silicon has made its breakthrough in various industries, including clinical and biomedical applications. Silicon-based biomaterials that were fabricated into various types of scaffolds may attract interest due to their highly favorable properties covering their excellent biocompatibility, high surface area, mechanical strength, and selectivity depending on their application including film, hydrogel, nanoparticles, and so on. Silicon-based materials have also shown exciting results involving cell culture, cell growth, as well as tissue engineering. In this article, a simple review compromising the evaluation of silicon’s unique properties has been discussed and followed by the application of the silicone-based product in future perspectives in biomedical fields. The review goals are to widen and inspire broader interest in silicone-based materials in wound healing research. Full article
(This article belongs to the Special Issue Multifunctional Natural-Based Polymers for Tissue Engineering & Regenerative Medicine)
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31 pages, 4276 KiB  
Review
Modelling of Stem Cells Microenvironment Using Carbon-Based Scaffold for Tissue Engineering Application—A Review
by Vieralynda Vitus, Fatimah Ibrahim and Wan Safwani Wan Kamarul Zaman
Polymers 2021, 13(23), 4058; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13234058 - 23 Nov 2021
Cited by 4 | Viewed by 2219
Abstract
A scaffold is a crucial biological substitute designed to aid the treatment of damaged tissue caused by trauma and disease. Various scaffolds are developed with different materials, known as biomaterials, and have shown to be a potential tool to facilitate in vitro cell [...] Read more.
A scaffold is a crucial biological substitute designed to aid the treatment of damaged tissue caused by trauma and disease. Various scaffolds are developed with different materials, known as biomaterials, and have shown to be a potential tool to facilitate in vitro cell growth, proliferation, and differentiation. Among the materials studied, carbon materials are potential biomaterials that can be used to develop scaffolds for cell growth. Recently, many researchers have attempted to build a scaffold following the origin of the tissue cell by mimicking the pattern of their extracellular matrix (ECM). In addition, extensive studies were performed on the various parameters that could influence cell behaviour. Previous studies have shown that various factors should be considered in scaffold production, including the porosity, pore size, topography, mechanical properties, wettability, and electroconductivity, which are essential in facilitating cellular response on the scaffold. These interferential factors will help determine the appropriate architecture of the carbon-based scaffold, influencing stem cell (SC) response. Hence, this paper reviews the potential of carbon as a biomaterial for scaffold development. This paper also discusses several crucial factors that can influence the feasibility of the carbon-based scaffold architecture in supporting the efficacy and viability of SCs. Full article
(This article belongs to the Special Issue Multifunctional Natural-Based Polymers for Tissue Engineering & Regenerative Medicine)
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21 pages, 2750 KiB  
Review
Wound Healing with Electrical Stimulation Technologies: A Review
by Yt Jun Cheah, Muhamad Ramdzan Buyong and Mohd Heikal Mohd Yunus
Polymers 2021, 13(21), 3790; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13213790 - 01 Nov 2021
Cited by 35 | Viewed by 6556
Abstract
Electrical stimulation (ES) is an attractive field among clinicians in the topic of wound healing, which is common yet complicated and requires multidisciplinary approaches. The conventional dressing and skin graft showed no promise on complete wound closure. These urge the need for the [...] Read more.
Electrical stimulation (ES) is an attractive field among clinicians in the topic of wound healing, which is common yet complicated and requires multidisciplinary approaches. The conventional dressing and skin graft showed no promise on complete wound closure. These urge the need for the exploration of electrical stimulation to supplement current wound care management. This review aims to provide an overview of electrical stimulation in wound healing. The mechanism of galvanotaxis related to wound repair will be reviewed at the cellular and molecular levels. Meanwhile, different modalities of externally applied electricity mimicking a physiologic electric field will be discussed and compared in vitro, in vivo, and clinically. With the emerging of tissue engineering and regenerative medicine, the integration of electroconductive biomaterials into modern miniaturised dressing is of interest and has become possible with the advancing understanding of smart biomaterials. Full article
(This article belongs to the Special Issue Multifunctional Natural-Based Polymers for Tissue Engineering & Regenerative Medicine)
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