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Polymers
Special Issues
Stimuli-Sensitive Amphiphilic Polymers and Their Biomedical Applications
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Stimuli-Sensitive Amphiphilic Polymers and Their Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 24435

Special Issue Editor

Prof. Dr. Jin-Chul Kim

E-Mail Website
Guest Editor
Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Kangwon-do 200-701, Korea
Interests: colloid and interface science; drug delivery system; polymer science

Special Issue Information

Dear Colleagues,

Amphiphilic polymers are interface-active and self-assembled in an aqueous phase, and they can be applied to biomedical fields including drug delivery and biomaterials science. Stimuli-sensitive polymers can change their configuration in response to stimuli such as temperature change, pH change, light, electric field, magnetic field, ultrasound, etc. The scope of this Special Issue covers stimuli-sensitive polymers, amphiphilic polymers, or both stimuli-sensitive and amphiphilic polymers. Drug carriers that release their payloads in answer to stimuli can be fabricated using stimuli-sensitive polymers. Self-assemblies including polymeric micelles and polymeric vesicles can be prepared using amphiphilic polymers. In addition, self-assemblies can be made to be responsive to stimuli in terms of release when stimuli-sensitive amphiphilic polymers are used as building blocks. Not only limited to biomedical fields, the applications to other industrial fields including separation, surface coating, colloidal stabilization, surfactants chemistry, and so on are acceptable.

Prof. Dr. Jin-Chul Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stimuli-sensitive polymers
  • amphiphilic polymers
  • biomedical applications
  • drug delivery
  • biomaterials
  • polymeric surfactants

Published Papers (3 papers)

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Research

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10 pages, 3337 KiB  
Article
An Active and Soft Hydrogel Actuator to Stimulate Live Cell Clusters by Self-folding
by Jun Woo Lim, Hee-jin Kim, Yechan Kim, Sung Gyu Shin, Sungwoo Cho, Woong Gyu Jung and Jae Hyun Jeong
Polymers 2020, 12(3), 583; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12030583 - 05 Mar 2020
Cited by 11 | Viewed by 3617
Abstract
The hydrogels are widely used in various applications, and their successful uses depend on controlling the mechanical properties. In this study, we present an advanced strategy to develop hydrogel actuator designed to stimulate live cell clusters by self-folding. The hydrogel actuator consisting of [...] Read more.
The hydrogels are widely used in various applications, and their successful uses depend on controlling the mechanical properties. In this study, we present an advanced strategy to develop hydrogel actuator designed to stimulate live cell clusters by self-folding. The hydrogel actuator consisting of two layers with different expansion ratios were fabricated to have various curvatures in self-folding. The expansion ratio of the hydrogel tuned with the molecular weight and concentration of gel-forming polymers, and temperature-sensitive molecules in a controlled manner. As a result, the hydrogel actuator could stimulate live cell clusters by compression and tension repeatedly, in response to temperature. The cell clusters were compressed in the 0.7-fold decreases of the radius of curvature with 1.0 mm in room temperature, as compared to that of 1.4 mm in 37 °C. Interestingly, the vascular endothelial growth factor (VEGF) and insulin-like growth factor-binding protein-2 (IGFBP-2) in MCF-7 tumor cells exposed by mechanical stimulation was expressed more than in those without stimulation. Overall, this new strategy to prepare the active and soft hydrogel actuator would be actively used in tissue engineering, drug delivery, and micro-scale actuators. Full article
(This article belongs to the Special Issue Stimuli-Sensitive Amphiphilic Polymers and Their Biomedical Applications)
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15 pages, 4847 KiB  
Article
Oxidation–Responsive Emulsions Stabilized with Poly(Vinyl Pyrrolidone-co-allyl Phenyl Sulfide)
by Seok Ho Park and Jin-Chul Kim
Polymers 2020, 12(2), 498; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12020498 - 24 Feb 2020
Cited by 3 | Viewed by 2935
Abstract
Oxidation-responsive emulsions were obtained by stabilizing mineral oil droplets using amphiphilic poly(vinyl pyrrolidone-co-allyl phenyl sulfide) (P(VP-APS)). 1H nuclear magnetic resonance (NMR) spectroscopy revealed that P(VP-APS) whose APS content was 0%, 3.28%, 3.43% and 4.58% were successfully prepared by free radical reaction and [...] Read more.
Oxidation-responsive emulsions were obtained by stabilizing mineral oil droplets using amphiphilic poly(vinyl pyrrolidone-co-allyl phenyl sulfide) (P(VP-APS)). 1H nuclear magnetic resonance (NMR) spectroscopy revealed that P(VP-APS) whose APS content was 0%, 3.28%, 3.43% and 4.58% were successfully prepared by free radical reaction and the sulfide of APS was oxidized by H2O2 treatment. X-ray Photoelectron Spectroscopy (XPS) also disclosed that the sulfide of APS was oxidized to sulfone by the oxidizing agent. The optical density of copolymer solutions and the interfacial activity of the copolymers markedly decreased by H2O2 treatment possibly because the sulfide of APS was oxidized and the amphiphilicity of the copolymers were weakened. The increase rate of the oil droplet diameter of the emulsions was outstandingly promoted when H2O2 solution (10%, v/v) was used as an aqueous phase. The phase separation of the emulsions was also expedited by the oxidizing agent. The oxidation of APS and the weakened interfacial activity were thought to be a main reason for the demulsification of P(VP-APS)-stabilized emulsions. Full article
(This article belongs to the Special Issue Stimuli-Sensitive Amphiphilic Polymers and Their Biomedical Applications)
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Review

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22 pages, 2296 KiB  
Review
Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications
by Xiaomin Xu, Yang Liu, Wenbo Fu, Mingyu Yao, Zhen Ding, Jiaming Xuan, Dongxiang Li, Shengjie Wang, Yongqing Xia and Meiwen Cao
Polymers 2020, 12(3), 580; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12030580 - 05 Mar 2020
Cited by 219 | Viewed by 17437
Abstract
Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make [...] Read more.
Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make up for these deficiencies, which can greatly benefit their practical applications. This review seeks to provide a comprehensive observation about the PNIPAM-based composite hydrogels for biomedical applications so as to guide related research. It covers the general principles from the materials choice to the hybridization strategies as well as the performance improvement by focusing on several application areas including drug delivery, tissue engineering and wound dressing. The most effective strategies include incorporation of functional inorganic nanoparticles or self-assembled structures to give composite hydrogels and linking PNIPAM with other polymer blocks of unique properties to produce copolymeric hydrogels, which can improve the properties of the hydrogels by enhancing the mechanical strength, giving higher biocompatibility and biodegradability, introducing multi-stimuli responsibility, enabling higher drug loading capacity as well as controlled release. These aspects will be of great help for promoting the development of PNIPAM-based composite materials for biomedical applications. Full article
(This article belongs to the Special Issue Stimuli-Sensitive Amphiphilic Polymers and Their Biomedical Applications)
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