Processes

Journal Browser

► Journal Browser

Special Issue Editors

Special Issue Information

Dear Colleagues,

Experimental pharmacology is a vast field based on research for drug design that is used for the discovery and evaluation of new active substances, and it is indispensable in the non-clinical development of medicines. In a broader sense, experimental pharmacology is an essential tool in the advancement of preclinical and clinical studies used in the process of drug design and the evaluation, and authorization of new substances. For this purpose, pharmacokinetics, pharmacodynamics, and pharmacotoxicology research is carried out. Sometimes, in the process of developing new drugs in clinical trials, research can return to the experimental, non-clinical phase, precisely to find new mechanisms of action of the substances undergoing testing, which results from clinical observations. There are many situations in which pharmacology, for example discovering new pharmacological receptors, opens horizons for the description of new molecular structures or previously unknown biological functions, which are then explored by physiologists, biologists, or pathologists.

This Special Issue entitled “Advances in Pharmacodynamics and Drug Design Process” intends to present both reviews and original studies regarding research on the drug design process and also the mechanism of action of different substances by using experimental pharmacology methods.

The topics in this Special Issue include but are not limited to:

Experimental pharmacology in drug design
Clinical pharmacology in drug design
Neuropsychopharmacology
Pharmacology of pain
Pharmacology in metabolic diseases

Prof. Dr. Oana Andreia Coman
Prof. Dr. Cristina Mihaela Ghiciuc
Dr. Isabel Ghiță
Dr. Anca Pantea Stoian
Dr. Horia Păunescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

experimental pharmacology
clinical pharmacology
pain
metabolic diseases
central nervous system diseases
drug design

Published Papers (1 paper)

Research

12 pages, 4986 KiB

Open AccessArticle

Experimental Research on the Influence of Ion Channels on the Healing of Skin Wounds in Rats

by Alexandra Grigore, Ana Vatasescu-Balcan, Smaranda Stoleru, Aurelian Zugravu, Elena Poenaru, Miruna Engi, Oana Andreia Coman and Ion Fulga

Processes 2024, 12(1), 109; https://0-doi-org.brum.beds.ac.uk/10.3390/pr12010109 - 01 Jan 2024

Cited by 1 | Viewed by 879

Abstract

At the level of skin wounds, an electrical potential difference develops between the edges of the wound and the center of the wound, which favors the migration of cells in the process of their healing. Cells migrate in an electric field because they have a certain electrical membrane potential. This potential is due to differences in the transmembrane electrochemical gradient. The transmembrane electrochemical gradient is due to the migration of sodium, potassium, and calcium ions into the corresponding ion channels. If this is the case, the modification of the functionality of these ion channels should influence the membrane potential and, as a consequence, the wound healing process. In this experiment, we set out to investigate whether the chemical manipulation of ion channels by amiodarone influences the wound healing process. Amiodarone blocks several types of ion channels, but at different concentrations: at low concentrations, it blocks only potassium channels; at medium concentrations, potassium and calcium channels; and at high concentrations, it blocks potassium, calcium, and sodium channels. We worked on rats that were given experimental skin lesions and evaluated the influence of the healing of these lesions upon the topical administration of amiodarone in three concentrations, 200 nM, 2000 nM and 200,000 nM, compared to an untreated group and a group treated with benzyl alcohol, the amiodarone solvent. In our experimental conditions, low concentration amiodarone promoted wound healing both in terms of duration of healing and also in terms of speed of healing. This means that blocking some ions, possibly potassium channels, might promote wound healing. Full article

(This article belongs to the Special Issue Advances in Pharmacodynamics and Drug Design Process)

► Show Figures